ENSG00000272602

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000502981 ENSG00000272602 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF595 protein_coding retained_intron 3.021747 3.166252 3.120098 0.2358279 0.3414434 -0.02111739 1.4994815 2.6396415 1.010572 0.19839896 0.1308379 -1.376418 0.49959167 0.83513333 0.3226333 -0.51250000 3.468723e-11 5.532156e-20   FALSE
ENST00000509152 ENSG00000272602 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF595 protein_coding protein_coding 3.021747 3.166252 3.120098 0.2358279 0.3414434 -0.02111739 1.3692649 0.4233412 2.109526 0.09997169 0.2130731 2.290166 0.44532917 0.13060000 0.6773667 0.54676667 5.532156e-20 5.532156e-20   FALSE
MSTRG.24378.5 ENSG00000272602 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF595 protein_coding   3.021747 3.166252 3.120098 0.2358279 0.3414434 -0.02111739 0.1497527 0.1032692 0.000000 0.10326923 0.0000000 -3.501684 0.05385417 0.03426667 0.0000000 -0.03426667 7.340971e-01 5.532156e-20   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000272602 E001 0.000000       4 53286 53294 9 +      
ENSG00000272602 E002 0.000000       4 53295 53303 9 +      
ENSG00000272602 E003 1.136385 0.3435955808 0.64914629 0.76049105 4 53304 53320 17 + 0.241 0.343 0.696
ENSG00000272602 E004 1.955359 0.1221224803 0.53534342 0.66719650 4 53321 53328 8 + 0.510 0.392 -0.604
ENSG00000272602 E005 23.911702 0.0011438483 0.52881862 0.66168952 4 53329 53491 163 + 1.408 1.366 -0.145
ENSG00000272602 E006 26.089071 0.0008573164 0.50599800 0.64170060 4 59430 59556 127 + 1.401 1.434 0.114
ENSG00000272602 E007 15.674428 0.0019704195 0.61446563 0.73293208 4 60058 60153 96 + 1.201 1.236 0.122
ENSG00000272602 E008 5.878787 0.0244212678 0.04180106 0.09436695 4 60154 60514 361 + 0.638 0.923 1.140
ENSG00000272602 E009 1.952053 0.0079517132 0.06239990 0.13068755 4 67840 68048 209 + 0.638 0.330 -1.558
ENSG00000272602 E010 3.145863 0.1620153584 0.10123112 0.19234637 4 68049 68500 452 + 0.793 0.465 -1.445
ENSG00000272602 E011 0.000000       4 85731 88208 2478 +