ENSG00000272556

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000609439 ENSG00000272556 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 5.232527 6.151812 2.895215 0.8855845 0.2405193 -1.08471 0.7738164 0.74773540 0.5380733 0.09677000 0.06009732 -0.4673252 0.15048750 0.123233333 0.18503333 0.06180000 0.25560595 0.001774903 FALSE TRUE
ENST00000685410 ENSG00000272556 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 5.232527 6.151812 2.895215 0.8855845 0.2405193 -1.08471 0.2174546 0.06974199 0.3268636 0.06974199 0.05587123 2.0787531 0.04586667 0.011166667 0.11156667 0.10040000 0.02962158 0.001774903   FALSE
MSTRG.29832.10 ENSG00000272556 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.232527 6.151812 2.895215 0.8855845 0.2405193 -1.08471 0.1052932 0.00000000 0.1954492 0.00000000 0.19544916 4.3607095 0.03367500 0.000000000 0.07363333 0.07363333 0.71941869 0.001774903 FALSE TRUE
MSTRG.29832.3 ENSG00000272556 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.232527 6.151812 2.895215 0.8855845 0.2405193 -1.08471 0.2234861 0.06549484 0.1199139 0.03318834 0.04229417 0.7831064 0.05121667 0.009433333 0.04396667 0.03453333 0.16049678 0.001774903 FALSE FALSE
MSTRG.29832.5 ENSG00000272556 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.232527 6.151812 2.895215 0.8855845 0.2405193 -1.08471 0.6558016 0.55300423 0.4392380 0.26737586 0.13291935 -0.3256658 0.15727083 0.089900000 0.16080000 0.07090000 0.62377403 0.001774903   FALSE
MSTRG.29832.7 ENSG00000272556 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.232527 6.151812 2.895215 0.8855845 0.2405193 -1.08471 1.1648354 1.23627338 0.6534280 0.13207303 0.07890882 -0.9096088 0.21144583 0.203933333 0.22436667 0.02043333 0.81233161 0.001774903 TRUE TRUE
MSTRG.29832.9 ENSG00000272556 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   5.232527 6.151812 2.895215 0.8855845 0.2405193 -1.08471 1.7301138 3.20743096 0.5477053 0.80570988 0.30047115 -2.5283343 0.28915833 0.515866667 0.17853333 -0.33733333 0.31244437 0.001774903 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000272556 E001 0.7728905 0.0152946039 4.305198e-02 9.664391e-02 7 45769060 45769104 45 + 0.426 0.098 -2.717
ENSG00000272556 E002 4.3847866 0.0866728799 9.085404e-03 2.649430e-02 7 45769105 45769467 363 + 0.930 0.521 -1.696
ENSG00000272556 E003 0.0000000       7 45769468 45769487 20 +      
ENSG00000272556 E004 2.4421987 0.1420639795 5.547755e-02 1.188074e-01 7 45773564 45773594 31 + 0.715 0.359 -1.702
ENSG00000272556 E005 3.0688698 0.1469148175 1.946965e-01 3.196189e-01 7 45773595 45773673 79 + 0.715 0.490 -1.002
ENSG00000272556 E006 2.5003734 0.0066122589 1.602126e-01 2.754072e-01 7 45774760 45774891 132 + 0.637 0.444 -0.909
ENSG00000272556 E007 6.0668998 0.0254853909 2.517360e-01 3.879969e-01 7 45778187 45778402 216 + 0.908 0.783 -0.483
ENSG00000272556 E008 3.3631658 0.0075492701 2.588801e-01 3.962076e-01 7 45779275 45779340 66 + 0.714 0.578 -0.582
ENSG00000272556 E009 3.2095621 0.0054443498 7.744276e-02 1.553529e-01 7 45781495 45781553 59 + 0.747 0.516 -1.008
ENSG00000272556 E010 3.5948425 0.0085544665 7.296749e-02 1.482749e-01 7 45782645 45782739 95 + 0.779 0.549 -0.979
ENSG00000272556 E011 6.2675708 0.0947704469 7.618723e-02 1.534167e-01 7 45782740 45782914 175 + 0.989 0.732 -0.992
ENSG00000272556 E012 1.1071269 0.2291967362 9.242560e-01 9.563033e-01 7 45783071 45783146 76 + 0.263 0.311 0.325
ENSG00000272556 E013 0.0000000       7 45783147 45783157 11 +      
ENSG00000272556 E014 3.0863748 0.0086881643 4.999472e-02 1.091698e-01 7 45788719 45788954 236 + 0.747 0.482 -1.176
ENSG00000272556 E015 2.6927015 0.0894341457 9.696294e-02 1.858436e-01 7 45791788 45791852 65 + 0.714 0.442 -1.240
ENSG00000272556 E016 4.2613707 0.0067158570 7.803322e-03 2.328350e-02 7 45795075 45795198 124 + 0.885 0.549 -1.393
ENSG00000272556 E017 2.6789442 0.0063236467 9.263898e-02 1.792517e-01 7 45797043 45797140 98 + 0.677 0.444 -1.078
ENSG00000272556 E018 2.8628387 0.0083197773 1.450778e-01 2.549446e-01 7 45797478 45797506 29 + 0.677 0.482 -0.885
ENSG00000272556 E019 2.9401579 0.0056379076 2.803022e-02 6.807216e-02 7 45797507 45797526 20 + 0.747 0.444 -1.369
ENSG00000272556 E020 5.7018311 0.0140952512 2.133277e-02 5.428892e-02 7 45797527 45797674 148 + 0.951 0.684 -1.051
ENSG00000272556 E021 3.6420839 0.0177431945 1.805036e-01 3.018143e-01 7 45798539 45798603 65 + 0.747 0.579 -0.715
ENSG00000272556 E022 0.2998086 0.0305067690 6.599473e-01   7 45798604 45798707 104 + 0.152 0.098 -0.721
ENSG00000272556 E023 0.9662351 0.0335055450 4.755181e-01 6.142303e-01 7 45804232 45804350 119 + 0.353 0.246 -0.720
ENSG00000272556 E024 0.2965864 0.3991352620 5.279020e-01   7 45804351 45804481 131 + 0.000 0.173 9.586
ENSG00000272556 E025 8.3265618 0.0023487901 6.781635e-02 1.397420e-01 7 45805099 45805289 191 + 1.042 0.881 -0.601
ENSG00000272556 E026 1.6743927 0.2104982117 1.659657e-01 2.829444e-01 7 45806913 45807098 186 + 0.595 0.298 -1.570
ENSG00000272556 E027 4.4149705 0.0085480753 9.399586e-01 9.663088e-01 7 45807340 45807397 58 + 0.677 0.705 0.117
ENSG00000272556 E028 14.1976597 0.0014000467 8.204609e-02 1.627512e-01 7 45807490 45808024 535 + 1.216 1.103 -0.402
ENSG00000272556 E029 26.9086011 0.0008420022 1.639399e-02 4.360169e-02 7 45808025 45808921 897 + 1.486 1.373 -0.391
ENSG00000272556 E030 12.7763776 0.0216502392 2.997892e-01 4.413748e-01 7 45808922 45809330 409 + 1.169 1.092 -0.276
ENSG00000272556 E031 72.2639839 0.0004443291 7.306821e-02 1.484408e-01 7 45809331 45811860 2530 + 1.749 1.869 0.404
ENSG00000272556 E032 9.6547123 0.0031655495 2.855247e-01 4.258593e-01 7 45811861 45812031 171 + 0.885 1.048 0.605
ENSG00000272556 E033 26.3326683 0.0008609658 6.718672e-05 3.665358e-04 7 45812032 45813209 1178 + 1.144 1.494 1.224
ENSG00000272556 E034 4.7906392 0.0920930557 5.319082e-01 6.643094e-01 7 45813210 45813262 53 + 0.808 0.719 -0.358
ENSG00000272556 E035 8.4274972 0.0021526007 3.332825e-01 4.769807e-01 7 45813263 45813393 131 + 0.990 0.922 -0.251
ENSG00000272556 E036 4.7846983 0.0035782846 2.316356e-01 3.644074e-01 7 45813394 45813413 20 + 0.808 0.682 -0.510
ENSG00000272556 E037 4.6856368 0.0061948837 1.187874e-01 2.182177e-01 7 45813414 45813458 45 + 0.835 0.659 -0.716
ENSG00000272556 E038 7.4302535 0.0770335752 7.070778e-01 8.050832e-01 7 45813459 45813508 50 + 0.886 0.894 0.033
ENSG00000272556 E039 5.6234027 0.1584590695 7.178378e-01 8.131172e-01 7 45813509 45813688 180 + 0.779 0.798 0.074
ENSG00000272556 E040 3.0624228 0.0056292325 2.980993e-01 4.394968e-01 7 45813689 45813737 49 + 0.426 0.634 0.985
ENSG00000272556 E041 6.8473861 0.0027775882 5.502346e-01 6.798783e-01 7 45813738 45813785 48 + 0.779 0.895 0.454
ENSG00000272556 E042 100.8219773 0.0282986649 1.002911e-05 6.663343e-05 7 45813786 45815263 1478 + 1.679 2.077 1.342