ENSG00000272333

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420124 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding protein_coding 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 4.5550026 3.3608628 4.3615536 0.7467412 0.4713601 0.3750282 0.17972083 0.10690000 0.22663333 0.11973333 0.01267681 3.201098e-05 FALSE TRUE
ENST00000592092 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding retained_intron 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 1.3791212 0.7264894 0.8377929 0.4329154 0.1471470 0.2030471 0.05264167 0.02323333 0.04443333 0.02120000 0.45305968 3.201098e-05 TRUE TRUE
ENST00000674101 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding protein_coding 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 1.5213169 2.7019100 0.9225206 0.8959613 0.1683551 -1.5401018 0.05105833 0.08386667 0.04946667 -0.03440000 0.55792090 3.201098e-05 FALSE TRUE
ENST00000674114 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding nonsense_mediated_decay 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 2.2594106 4.5212432 0.2611474 0.5866491 0.2611474 -4.0627580 0.07228750 0.14583333 0.01373333 -0.13210000 0.03639113 3.201098e-05 FALSE TRUE
ENST00000685062 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding retained_intron 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 1.2803642 0.4936407 1.0252752 0.2535787 0.2424998 1.0395476 0.05022917 0.01523333 0.05453333 0.03930000 0.34795227 3.201098e-05   FALSE
ENST00000689544 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding retained_intron 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 2.4472058 3.3607133 1.3576773 1.9374567 0.2466613 -1.3013260 0.08299167 0.10486667 0.06973333 -0.03513333 0.99187509 3.201098e-05 TRUE TRUE
ENST00000691421 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding protein_coding 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 1.3524025 1.3827871 1.6271011 0.9283059 0.2381171 0.2331687 0.05428333 0.04726667 0.08386667 0.03660000 0.63292473 3.201098e-05 FALSE TRUE
ENST00000693161 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding protein_coding 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 0.7740805 1.5011031 0.0000000 1.0220820 0.0000000 -7.2394582 0.02330417 0.05126667 0.00000000 -0.05126667 0.22284543 3.201098e-05 FALSE TRUE
ENST00000693175 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding nonsense_mediated_decay 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 1.8360771 3.7918825 0.6060178 2.0996533 0.3587180 -2.6256700 0.06030000 0.12950000 0.02926667 -0.10023333 0.81325039 3.201098e-05 FALSE TRUE
ENST00000693677 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding protein_coding 27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 0.3577445 1.7915208 0.0000000 0.9566356 0.0000000 -7.4930715 0.01243333 0.06246667 0.00000000 -0.06246667 0.20325897 3.201098e-05 FALSE TRUE
MSTRG.16990.11 ENSG00000272333 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2B protein_coding   27.32794 30.8513 19.23108 2.682774 1.30181 -0.6816096 3.3807251 2.4485500 3.4819273 0.5992690 0.4277564 0.5062158 0.13327500 0.07740000 0.18096667 0.10356667 0.01129920 3.201098e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000272333 E001 0.2903454 0.3782102436 1.977070e-01   19 35717973 35718002 30 + 0.245 0.000 -10.473
ENSG00000272333 E002 3.8784879 0.0255469772 2.914889e-08 3.288572e-07 19 35718003 35718178 176 + 1.021 0.107 -5.088
ENSG00000272333 E003 3.7040803 0.1670980433 3.952161e-03 1.300818e-02 19 35718179 35718206 28 + 0.935 0.327 -2.762
ENSG00000272333 E004 20.3852780 0.0141539004 9.689577e-03 2.799818e-02 19 35718207 35718381 175 + 1.435 1.210 -0.783
ENSG00000272333 E005 28.0690642 0.0013592225 1.369987e-02 3.753885e-02 19 35719469 35719541 73 + 1.527 1.374 -0.529
ENSG00000272333 E006 27.8406218 0.0007148461 3.400283e-02 7.976589e-02 19 35719784 35719849 66 + 1.512 1.383 -0.444
ENSG00000272333 E007 188.4801398 0.0009572832 1.361357e-21 1.037847e-19 19 35719850 35720901 1052 + 2.405 2.139 -0.888
ENSG00000272333 E008 34.2857779 0.0005879687 2.497243e-05 1.514438e-04 19 35720902 35720940 39 + 1.661 1.422 -0.819
ENSG00000272333 E009 89.4866703 0.0077785770 8.559613e-06 5.776961e-05 19 35720941 35721373 433 + 2.070 1.834 -0.793
ENSG00000272333 E010 146.6574572 0.0025868767 3.440766e-06 2.542785e-05 19 35721374 35721804 431 + 2.243 2.083 -0.536
ENSG00000272333 E011 0.2934659 0.0290785164 8.066300e-01   19 35722332 35722358 27 + 0.140 0.107 -0.447
ENSG00000272333 E012 73.8888976 0.0006134405 2.564525e-02 6.321124e-02 19 35722359 35722472 114 + 1.903 1.820 -0.279
ENSG00000272333 E013 94.7232197 0.0045812145 3.325795e-03 1.122285e-02 19 35722568 35722718 151 + 2.035 1.908 -0.426
ENSG00000272333 E014 140.7238752 0.0085749432 1.297044e-03 4.966571e-03 19 35722995 35723243 249 + 2.221 2.070 -0.504
ENSG00000272333 E015 63.7920176 0.0131910329 2.925642e-02 7.050145e-02 19 35723244 35723272 29 + 1.870 1.736 -0.453
ENSG00000272333 E016 47.4987725 0.0085842814 6.679786e-03 2.039067e-02 19 35723273 35723274 2 + 1.760 1.594 -0.564
ENSG00000272333 E017 3.0486852 0.0058302784 2.106953e-02 5.374172e-02 19 35723403 35723446 44 + 0.773 0.427 -1.559
ENSG00000272333 E018 78.7816895 0.0051268809 1.637038e-03 6.079825e-03 19 35723447 35723502 56 + 1.968 1.819 -0.499
ENSG00000272333 E019 7.7266004 0.0588688393 7.347486e-03 2.212163e-02 19 35723503 35723731 229 + 1.132 0.719 -1.567
ENSG00000272333 E020 103.0599709 0.0070606984 1.036281e-01 1.960224e-01 19 35723732 35723943 212 + 2.039 1.971 -0.228
ENSG00000272333 E021 47.7345749 0.0173404870 6.575145e-02 1.362894e-01 19 35723944 35724007 64 + 1.742 1.616 -0.428
ENSG00000272333 E022 36.3206182 0.0197973177 1.765424e-01 2.967513e-01 19 35724637 35724638 2 + 1.611 1.511 -0.342
ENSG00000272333 E023 72.1097247 0.0209650508 2.597594e-02 6.389747e-02 19 35724639 35724731 93 + 1.940 1.778 -0.546
ENSG00000272333 E024 70.8066043 0.0079443249 1.142771e-03 4.446933e-03 19 35724989 35725087 99 + 1.940 1.762 -0.601
ENSG00000272333 E025 81.2963639 0.0007838310 2.033656e-04 9.782399e-04 19 35725220 35725333 114 + 1.977 1.836 -0.472
ENSG00000272333 E026 106.3794892 0.0016918500 2.363953e-02 5.906881e-02 19 35725479 35725625 147 + 2.055 1.979 -0.254
ENSG00000272333 E027 90.3589815 0.0018163590 1.403636e-02 3.830740e-02 19 35725723 35725818 96 + 1.992 1.902 -0.302
ENSG00000272333 E028 0.8469850 0.0136968632 3.086831e-01 4.509527e-01 19 35725819 35725830 12 + 0.140 0.325 1.554
ENSG00000272333 E029 92.4529591 0.0028152278 3.755522e-02 8.650713e-02 19 35726236 35726330 95 + 1.997 1.919 -0.261
ENSG00000272333 E030 62.3839471 0.0003837527 9.822384e-04 3.899212e-03 19 35726331 35726353 23 + 1.864 1.728 -0.460
ENSG00000272333 E031 95.6459810 0.0003125234 5.843474e-04 2.475909e-03 19 35727156 35727269 114 + 2.034 1.919 -0.384
ENSG00000272333 E032 87.3211945 0.0008968474 1.196035e-01 2.194020e-01 19 35727438 35727592 155 + 1.957 1.907 -0.170
ENSG00000272333 E033 39.0199311 0.0010024176 8.791973e-01 9.264065e-01 19 35727593 35727622 30 + 1.573 1.594 0.069
ENSG00000272333 E034 72.8083624 0.0003809036 7.422489e-01 8.311952e-01 19 35727698 35727787 90 + 1.850 1.848 -0.008
ENSG00000272333 E035 93.0764810 0.0004471728 7.020612e-01 8.009567e-01 19 35727881 35727985 105 + 1.957 1.954 -0.009
ENSG00000272333 E036 85.1398178 0.0005095280 4.370904e-01 5.791177e-01 19 35728098 35728171 74 + 1.931 1.912 -0.064
ENSG00000272333 E037 2.1307106 0.1844825192 4.989521e-02 1.089840e-01 19 35728364 35728455 92 + 0.680 0.271 -2.127
ENSG00000272333 E038 123.4290829 0.0002549021 1.065406e-01 2.004556e-01 19 35728774 35728889 116 + 2.100 2.059 -0.137
ENSG00000272333 E039 108.0189779 0.0057279482 4.579616e-01 5.982957e-01 19 35728985 35729076 92 + 2.028 2.010 -0.061
ENSG00000272333 E040 64.0232998 0.0093969444 2.088683e-01 3.371633e-01 19 35729159 35729161 3 + 1.829 1.767 -0.210
ENSG00000272333 E041 110.7341187 0.0017484904 1.775385e-01 2.980522e-01 19 35729162 35729226 65 + 2.049 2.011 -0.128
ENSG00000272333 E042 101.5602619 0.0010900181 1.220960e-01 2.229187e-01 19 35729227 35729296 70 + 2.017 1.971 -0.155
ENSG00000272333 E043 11.4477721 0.0194034389 2.105330e-03 7.550516e-03 19 35729792 35729966 175 + 1.248 0.907 -1.242
ENSG00000272333 E044 142.2433086 0.0002518248 5.582586e-03 1.750710e-02 19 35729967 35730125 159 + 2.178 2.106 -0.242
ENSG00000272333 E045 142.8581997 0.0002177686 2.343736e-02 5.865595e-02 19 35730342 35730462 121 + 2.172 2.116 -0.190
ENSG00000272333 E046 124.2230761 0.0002526386 9.137071e-03 2.662524e-02 19 35730538 35730616 79 + 2.123 2.051 -0.243
ENSG00000272333 E047 123.9730380 0.0005594218 6.244605e-02 1.307625e-01 19 35730707 35730867 161 + 2.031 2.106 0.254
ENSG00000272333 E048 167.3679181 0.0027181200 3.784126e-01 5.227022e-01 19 35731908 35732135 228 + 2.180 2.228 0.160
ENSG00000272333 E049 87.7895980 0.0003191388 4.537758e-01 5.944851e-01 19 35732215 35732243 29 + 1.901 1.942 0.139
ENSG00000272333 E050 145.3424414 0.0002376035 6.404924e-01 7.537172e-01 19 35732244 35732329 86 + 2.148 2.146 -0.008
ENSG00000272333 E051 495.3433012 0.0002139363 1.078246e-05 7.110746e-05 19 35732330 35733485 1156 + 2.617 2.706 0.296
ENSG00000272333 E052 67.2482883 0.0004139758 2.791421e-03 9.648178e-03 19 35733486 35733508 23 + 1.715 1.863 0.501
ENSG00000272333 E053 8.4763033 0.0833455684 1.301169e-01 2.343225e-01 19 35733509 35733596 88 + 1.080 0.861 -0.817
ENSG00000272333 E054 101.9075245 0.0054642501 1.580351e-02 4.229548e-02 19 35733597 35733686 90 + 1.897 2.040 0.480
ENSG00000272333 E055 5.0867127 0.0436546748 1.216705e-01 2.223177e-01 19 35733687 35733748 62 + 0.894 0.668 -0.905
ENSG00000272333 E056 4.1182995 0.0618186446 3.698000e-01 5.142061e-01 19 35733749 35733762 14 + 0.774 0.640 -0.552
ENSG00000272333 E057 150.0250450 0.0040979373 1.102587e-03 4.311821e-03 19 35733763 35733872 110 + 2.056 2.214 0.526
ENSG00000272333 E058 13.5937816 0.0012780720 5.390795e-02 1.160996e-01 19 35735220 35736591 1372 + 1.239 1.075 -0.585
ENSG00000272333 E059 4.3638312 0.0050696538 2.990105e-01 4.404939e-01 19 35736592 35736689 98 + 0.800 0.665 -0.553
ENSG00000272333 E060 162.4794886 0.0002564739 2.483665e-08 2.842523e-07 19 35736690 35736788 99 + 2.073 2.253 0.600
ENSG00000272333 E061 111.5280938 0.0002850589 6.319258e-08 6.670555e-07 19 35736789 35736827 39 + 1.888 2.097 0.700
ENSG00000272333 E062 2.1338562 0.0074016206 3.848164e-01 5.289714e-01 19 35736828 35736911 84 + 0.563 0.427 -0.667
ENSG00000272333 E063 167.8271252 0.0009753273 1.318255e-08 1.589077e-07 19 35736912 35736986 75 + 2.072 2.271 0.667
ENSG00000272333 E064 243.5455779 0.0031276034 1.669779e-06 1.320923e-05 19 35737086 35737263 178 + 2.245 2.434 0.632
ENSG00000272333 E065 2.1326085 0.0122499673 4.276576e-01 5.705201e-01 19 35737468 35737588 121 + 0.401 0.545 0.723
ENSG00000272333 E066 4.6082027 0.0036252428 6.274969e-01 7.432982e-01 19 35737589 35737635 47 + 0.681 0.759 0.321
ENSG00000272333 E067 189.3991865 0.0054267149 3.141635e-04 1.437374e-03 19 35737636 35737743 108 + 2.146 2.324 0.594
ENSG00000272333 E068 203.6077525 0.0092858898 1.433810e-02 3.899887e-02 19 35737859 35737942 84 + 2.198 2.347 0.497
ENSG00000272333 E069 123.3162289 0.0101150245 1.288460e-01 2.325487e-01 19 35738062 35738066 5 + 2.009 2.118 0.366
ENSG00000272333 E070 141.0202125 0.0105759603 4.659187e-02 1.031054e-01 19 35738067 35738090 24 + 2.047 2.185 0.460
ENSG00000272333 E071 230.8976870 0.0064876173 7.311261e-04 3.011133e-03 19 35738091 35738191 101 + 2.233 2.408 0.584
ENSG00000272333 E072 395.9197849 0.0055518122 9.112644e-11 1.619478e-09 19 35738282 35738886 605 + 2.391 2.670 0.929