ENSG00000272047

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000607778 ENSG00000272047 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H5 protein_coding protein_coding 35.96265 48.81582 30.90559 6.990339 1.106895 -0.6593097 1.914534 1.608245 2.5262466 0.1177530 0.04624310 0.6482654 0.05668333 0.03380000 0.08206667 0.04826667 5.537161e-06 5.537161e-06    
ENST00000648328 ENSG00000272047 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H5 protein_coding protein_coding 35.96265 48.81582 30.90559 6.990339 1.106895 -0.6593097 7.450793 9.341097 6.8232627 1.3412563 0.76274723 -0.4525611 0.20330833 0.19140000 0.21970000 0.02830000 5.920497e-01 5.537161e-06    
ENST00000689809 ENSG00000272047 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H5 protein_coding protein_coding 35.96265 48.81582 30.90559 6.990339 1.106895 -0.6593097 18.468728 23.841251 15.5816765 5.0465109 0.31527112 -0.6132889 0.51201250 0.47970000 0.50570000 0.02600000 8.413595e-01 5.537161e-06    
MSTRG.29243.2 ENSG00000272047 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H5 protein_coding   35.96265 48.81582 30.90559 6.990339 1.106895 -0.6593097 2.140653 3.878969 0.6427709 0.3945966 0.03687903 -2.5747391 0.06253333 0.08426667 0.02080000 -0.06346667 4.068593e-04 5.537161e-06    
MSTRG.29243.4 ENSG00000272047 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H5 protein_coding   35.96265 48.81582 30.90559 6.990339 1.106895 -0.6593097 3.906480 7.084273 3.1675355 1.2944209 0.64651536 -1.1587466 0.10822500 0.14383333 0.10233333 -0.04150000 4.153001e-01 5.537161e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000272047 E001 0.9911135 0.0135090058 5.981323e-01 7.197923e-01 6 158168326 158168328 3 + 0.339 0.257 -0.556
ENSG00000272047 E002 4.0814520 0.0048391205 4.719534e-01 6.110339e-01 6 158168329 158168337 9 + 0.759 0.677 -0.336
ENSG00000272047 E003 8.0724337 0.0021182585 6.795794e-01 7.837263e-01 6 158168338 158168349 12 + 0.968 0.943 -0.092
ENSG00000272047 E004 10.0944161 0.0016950862 2.708129e-01 4.094712e-01 6 158168350 158168356 7 + 1.095 1.005 -0.328
ENSG00000272047 E005 16.2233896 0.0012407195 8.968701e-01 9.381193e-01 6 158168357 158168359 3 + 1.215 1.226 0.040
ENSG00000272047 E006 418.4297264 0.0026670649 5.468232e-01 6.769258e-01 6 158168360 158168395 36 + 2.610 2.605 -0.015
ENSG00000272047 E007 19.9559568 0.0180039644 3.850408e-02 8.828633e-02 6 158168396 158168627 232 + 1.147 1.369 0.781
ENSG00000272047 E008 12.3537699 0.0014527545 4.815343e-01 6.197702e-01 6 158168628 158168807 180 + 1.052 1.142 0.327
ENSG00000272047 E009 27.4197599 0.0007518958 7.161277e-01 8.118596e-01 6 158168808 158169002 195 + 1.413 1.461 0.165
ENSG00000272047 E010 684.9200368 0.0001654196 8.813271e-02 1.722812e-01 6 158170470 158170538 69 + 2.796 2.841 0.149
ENSG00000272047 E011 10.6403105 0.0912160128 3.050886e-02 7.296637e-02 6 158172357 158172536 180 + 0.758 1.151 1.476
ENSG00000272047 E012 0.0000000       6 158174782 158174875 94 +      
ENSG00000272047 E013 0.2987644 0.0293259757 1.106296e-01   6 158175654 158175693 40 + 0.253 0.000 -11.100
ENSG00000272047 E014 14.5088935 0.0012868148 5.454914e-01 6.758251e-01 6 158187040 158187121 82 + 1.134 1.212 0.275
ENSG00000272047 E015 1.3565986 0.2804609241 8.067400e-01 8.772348e-01 6 158187122 158187125 4 + 0.339 0.372 0.195
ENSG00000272047 E016 2.1681978 0.0076013301 6.197814e-01 7.370961e-01 6 158188118 158188170 53 + 0.527 0.459 -0.333
ENSG00000272047 E017 0.7448917 0.0829629342 7.316981e-03 2.204240e-02 6 158188431 158188886 456 + 0.473 0.000 -11.984
ENSG00000272047 E018 1498.8167341 0.0021991270 1.431287e-03 5.411157e-03 6 158191977 158193209 1233 + 3.122 3.180 0.193
ENSG00000272047 E019 93.6206026 0.0026591703 2.258049e-72 3.656245e-69 6 158193210 158199344 6135 + 2.298 1.484 -2.746