ENSG00000271270

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000603884 ENSG00000271270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1-DT lncRNA lncRNA 6.074685 4.849935 5.700476 0.7191447 0.354006 0.2326739 0.4638919 0.0000000 0.7924442 0.00000000 0.09746543 6.3263292 0.07136667 0.0000000 0.13916667 0.13916667 8.651611e-12 8.651611e-12 FALSE TRUE
ENST00000605830 ENSG00000271270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1-DT lncRNA lncRNA 6.074685 4.849935 5.700476 0.7191447 0.354006 0.2326739 0.5457259 0.6443385 1.0698298 0.09024800 0.14373837 0.7226948 0.09084583 0.1341333 0.18596667 0.05183333 3.295538e-01 8.651611e-12 FALSE FALSE
ENST00000653304 ENSG00000271270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1-DT lncRNA lncRNA 6.074685 4.849935 5.700476 0.7191447 0.354006 0.2326739 0.7817023 0.4395127 0.8696252 0.12274855 0.02304261 0.9685272 0.13218750 0.1039000 0.15330000 0.04940000 5.454624e-01 8.651611e-12 FALSE TRUE
ENST00000686063 ENSG00000271270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1-DT lncRNA lncRNA 6.074685 4.849935 5.700476 0.7191447 0.354006 0.2326739 0.9659088 0.9887646 0.3113481 0.02641783 0.17523411 -1.6360076 0.16103750 0.2133000 0.05116667 -0.16213333 1.496924e-01 8.651611e-12   FALSE
ENST00000690344 ENSG00000271270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1-DT lncRNA lncRNA 6.074685 4.849935 5.700476 0.7191447 0.354006 0.2326739 0.8845596 0.6881670 0.2773938 0.25609229 0.13875115 -1.2805433 0.14034167 0.1444333 0.04590000 -0.09853333 3.981032e-01 8.651611e-12   FALSE
MSTRG.23684.1 ENSG00000271270 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCC1-DT lncRNA   6.074685 4.849935 5.700476 0.7191447 0.354006 0.2326739 2.1099217 2.0110746 2.2384227 0.68023251 0.11132770 0.1537907 0.35171667 0.3910000 0.39780000 0.00680000 1.000000e+00 8.651611e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000271270 E001 0.1451727 0.0431195832 7.199334e-01   3 129893811 129893845 35 + 0.109 0.000 -9.509
ENSG00000271270 E002 0.2903454 0.3477854995 4.394811e-01   3 129893846 129893853 8 + 0.195 0.000 -11.702
ENSG00000271270 E003 0.8052565 0.2886009825 9.044977e-01 9.431763e-01 3 129893854 129893862 9 + 0.267 0.243 -0.180
ENSG00000271270 E004 1.7275861 0.0239875488 3.992979e-01 5.430305e-01 3 129893863 129893870 8 + 0.515 0.326 -1.020
ENSG00000271270 E005 2.8680370 0.0081939529 7.093015e-01 8.067271e-01 3 129893871 129893874 4 + 0.584 0.600 0.071
ENSG00000271270 E006 7.0711087 0.0025717253 1.242493e-01 2.260507e-01 3 129893875 129893881 7 + 1.004 0.767 -0.905
ENSG00000271270 E007 21.8581456 0.0021345576 7.124391e-02 1.454002e-01 3 129893882 129893927 46 + 1.331 1.408 0.265
ENSG00000271270 E008 5.1618145 0.0077334139 6.776134e-01 7.822837e-01 3 129893928 129894131 204 + 0.786 0.794 0.031
ENSG00000271270 E009 43.5006355 0.0022917379 1.282958e-02 3.551530e-02 3 129901707 129901850 144 + 1.619 1.696 0.261
ENSG00000271270 E010 23.6618254 0.0009551107 8.313068e-03 2.457533e-02 3 129901851 129901860 10 + 1.337 1.462 0.431
ENSG00000271270 E011 63.4819796 0.0665143644 6.523396e-04 2.724090e-03 3 129901861 129905020 3160 + 1.970 1.508 -1.566
ENSG00000271270 E012 20.7375935 0.0484481708 7.712491e-01 8.523110e-01 3 129905021 129905626 606 + 1.375 1.278 -0.339
ENSG00000271270 E013 65.9876413 0.0017030132 2.055600e-03 7.397654e-03 3 129905627 129905853 227 + 1.797 1.870 0.248
ENSG00000271270 E014 118.0367234 0.0005280030 9.926120e-01 9.994704e-01 3 129905854 129908911 3058 + 2.104 2.047 -0.192
ENSG00000271270 E015 4.8637120 0.0035987654 2.870127e-06 2.156831e-05 3 129918400 129918578 179 + 0.384 0.997 2.655