ENSG00000269929

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000362263 ENSG00000269929 HEK293_OSMI2_2hA HEK293_TMG_2hB MIRLET7A1HG lncRNA miRNA 7.806816 8.434638 4.286443 1.330627 0.8292042 -0.9748927 0.9809275 0.8604945 0.2470970 0.86049448 0.24709700 -1.7595224 0.10806250 0.08223333 0.04333333 -0.0389000 0.960540884 0.001033908   FALSE
ENST00000652769 ENSG00000269929 HEK293_OSMI2_2hA HEK293_TMG_2hB MIRLET7A1HG lncRNA lncRNA 7.806816 8.434638 4.286443 1.330627 0.8292042 -0.9748927 0.5210646 0.3150780 0.5726637 0.02049434 0.01059843 0.8418777 0.07579167 0.03860000 0.14410000 0.1055000 0.001033908 0.001033908   FALSE
ENST00000691101 ENSG00000269929 HEK293_OSMI2_2hA HEK293_TMG_2hB MIRLET7A1HG lncRNA lncRNA 7.806816 8.434638 4.286443 1.330627 0.8292042 -0.9748927 5.8259022 6.3334497 2.7297837 0.78924806 0.36618599 -1.2112056 0.74738750 0.76263333 0.65356667 -0.1090667 0.476553636 0.001033908   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000269929 E001 0.2214452 0.0385953146 6.908019e-01   9 94166258 94166265 8 + 0.000 0.102 9.799
ENSG00000269929 E002 0.5514428 0.0193874923 1.651428e-01 2.818769e-01 9 94166266 94166288 23 + 0.000 0.254 12.986
ENSG00000269929 E003 0.5514428 0.0193874923 1.651428e-01 2.818769e-01 9 94166289 94166289 1 + 0.000 0.254 12.986
ENSG00000269929 E004 1.0653097 0.0130700936 7.381424e-01 8.281006e-01 9 94166290 94166381 92 + 0.256 0.314 0.402
ENSG00000269929 E005 0.3299976 0.0265102580 3.326892e-01   9 94175865 94175956 92 + 0.000 0.184 12.450
ENSG00000269929 E006 0.0000000       9 94175957 94175965 9 +      
ENSG00000269929 E007 1.3995631 0.0108835380 1.084742e-01 2.032933e-01 9 94175966 94176346 381 + 0.532 0.254 -1.600
ENSG00000269929 E008 0.6633060 0.0388113579 1.654756e-01 2.823184e-01 9 94176347 94176429 83 + 0.343 0.102 -2.180
ENSG00000269929 E009 9.9200700 0.0477120249 3.201179e-03 1.085900e-02 9 94176430 94176943 514 + 1.242 0.818 -1.562
ENSG00000269929 E010 28.9782318 0.0009006728 3.192135e-09 4.309417e-08 9 94176944 94178833 1890 + 1.646 1.302 -1.184
ENSG00000269929 E011 4.2240577 0.0050372265 1.538734e-01 2.669346e-01 9 94178834 94178914 81 + 0.820 0.620 -0.822
ENSG00000269929 E012 51.4299245 0.0008022682 9.944156e-04 3.939198e-03 9 94178915 94179190 276 + 1.601 1.740 0.474
ENSG00000269929 E013 47.1786277 0.0009064757 2.735158e-05 1.642577e-04 9 94179191 94179564 374 + 1.535 1.727 0.653
ENSG00000269929 E014 0.4783925 0.0219745837 3.604654e-01 5.047757e-01 9 94179820 94179921 102 + 0.256 0.102 -1.599
ENSG00000269929 E015 1.1575045 0.2120759383 5.948422e-01 7.170194e-01 9 94183263 94183446 184 + 0.417 0.255 -1.015
ENSG00000269929 E016 6.5348562 0.0270529538 1.692828e-01 2.872509e-01 9 94200486 94200902 417 + 0.733 0.933 0.782