ENSG00000269893

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000384096 ENSG00000269893 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG8 lncRNA snoRNA 12.71106 11.19517 14.00196 0.8806271 0.210173 0.322495 5.3345051 3.179575 6.5004493 1.7084058 0.55172296 1.0293927 0.36560000 0.27176667 0.46326667 0.191500000 0.7227244648 0.0005090633    
ENST00000602520 ENSG00000269893 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG8 lncRNA lncRNA 12.71106 11.19517 14.00196 0.8806271 0.210173 0.322495 3.5751372 3.599616 3.9001793 0.7347569 0.24820952 0.1153895 0.30238333 0.32783333 0.27916667 -0.048666667 0.8500692898 0.0005090633    
ENST00000654083 ENSG00000269893 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG8 lncRNA lncRNA 12.71106 11.19517 14.00196 0.8806271 0.210173 0.322495 1.6431783 1.982589 1.5422086 0.2414184 0.01690500 -0.3603216 0.14435833 0.18153333 0.11016667 -0.071366667 0.2016452811 0.0005090633    
ENST00000688996 ENSG00000269893 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG8 lncRNA lncRNA 12.71106 11.19517 14.00196 0.8806271 0.210173 0.322495 0.6526312 1.185331 0.3712477 0.2833127 0.03066019 -1.6486101 0.05943333 0.10440000 0.02660000 -0.077800000 0.0005090633 0.0005090633    
ENST00000693179 ENSG00000269893 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG8 lncRNA lncRNA 12.71106 11.19517 14.00196 0.8806271 0.210173 0.322495 0.7957977 0.810918 1.0493095 0.0657748 0.08228143 0.3678142 0.06939167 0.07403333 0.07516667 0.001133333 0.9984445793 0.0005090633    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000269893 E001 0.7749789 0.0155616578 9.051309e-01 9.436213e-01 4 118278705 118278705 1 + 0.244 0.266 0.163
ENSG00000269893 E002 1.0748892 0.0163212358 1.331801e-01 2.385621e-01 4 118278706 118278707 2 + 0.460 0.194 -1.742
ENSG00000269893 E003 1.0748892 0.0163212358 1.331801e-01 2.385621e-01 4 118278708 118278713 6 + 0.460 0.194 -1.742
ENSG00000269893 E004 2.8118368 0.0063791279 2.832077e-01 4.233033e-01 4 118278714 118278717 4 + 0.678 0.512 -0.743
ENSG00000269893 E005 3.8104389 0.0045433214 1.334161e-01 2.388832e-01 4 118278718 118278722 5 + 0.797 0.581 -0.905
ENSG00000269893 E006 12.2350189 0.0014898672 7.303640e-01 8.223522e-01 4 118278723 118278730 8 + 1.140 1.108 -0.115
ENSG00000269893 E007 102.0598881 0.0002941284 7.634211e-01 8.467275e-01 4 118278731 118278754 24 + 2.001 2.012 0.035
ENSG00000269893 E008 103.1552995 0.0002935721 6.493427e-01 7.606357e-01 4 118278755 118278757 3 + 2.003 2.019 0.053
ENSG00000269893 E009 105.7704652 0.0002896715 5.032477e-01 6.392140e-01 4 118278758 118278758 1 + 2.010 2.033 0.078
ENSG00000269893 E010 591.4017870 0.0004129891 3.168322e-02 7.522894e-02 4 118278759 118278792 34 + 2.790 2.754 -0.118
ENSG00000269893 E011 104.8697246 0.0093426651 3.611289e-01 5.055072e-01 4 118278793 118278809 17 + 2.052 1.986 -0.224
ENSG00000269893 E012 131.1145244 0.0085535769 7.378630e-01 8.279108e-01 4 118278810 118278877 68 + 2.129 2.095 -0.113
ENSG00000269893 E013 138.7778256 0.0067221256 9.347087e-01 9.628763e-01 4 118278878 118278933 56 + 2.140 2.129 -0.037
ENSG00000269893 E014 82.0205859 0.0026128635 2.764846e-02 6.731016e-02 4 118278934 118278943 10 + 1.847 1.944 0.329
ENSG00000269893 E015 155.2768800 0.0015513350 6.522767e-11 1.186138e-09 4 118278944 118278965 22 + 2.036 2.259 0.748
ENSG00000269893 E016 270.5411426 0.0016803763 1.757933e-07 1.703592e-06 4 118278966 118279059 94 + 2.332 2.476 0.481
ENSG00000269893 E017 257.1193387 0.0019029768 9.648586e-06 6.438519e-05 4 118279060 118279106 47 + 2.322 2.449 0.423
ENSG00000269893 E018 254.9170794 0.0008520857 3.380984e-02 7.937607e-02 4 118279107 118279137 31 + 2.370 2.421 0.170
ENSG00000269893 E019 29.6098487 0.0006495859 5.361638e-04 2.295101e-03 4 118279138 118279189 52 + 1.599 1.381 -0.748
ENSG00000269893 E020 65.1247591 0.0004036055 1.149451e-09 1.684927e-08 4 118279190 118279388 199 + 1.955 1.691 -0.891
ENSG00000269893 E021 784.2085105 0.0010551341 2.280794e-02 5.734307e-02 4 118279389 118279431 43 + 2.914 2.871 -0.142
ENSG00000269893 E022 63.1532360 0.0028330160 2.477450e-06 1.889171e-05 4 118279432 118279623 192 + 1.929 1.686 -0.821
ENSG00000269893 E023 897.3801717 0.0020283733 7.569292e-02 1.526111e-01 4 118279624 118285316 5693 + 2.969 2.929 -0.134