ENSG00000269335

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000594239 ENSG00000269335 HEK293_OSMI2_2hA HEK293_TMG_2hB IKBKG protein_coding protein_coding 30.47362 53.4979 13.54452 4.259322 0.4547829 -1.980978 16.936349 33.009695 4.329234 2.5947601 0.1828369 -2.927815 0.50947917 0.61743333 0.31956667 -0.2978667 1.662430e-24 1.66243e-24 FALSE TRUE
ENST00000686378 ENSG00000269335 HEK293_OSMI2_2hA HEK293_TMG_2hB IKBKG protein_coding protein_coding 30.47362 53.4979 13.54452 4.259322 0.4547829 -1.980978 1.906578 2.496392 1.128169 0.3675710 0.1021032 -1.138897 0.06900833 0.04623333 0.08303333 0.0368000 1.368816e-02 1.66243e-24 FALSE TRUE
ENST00000687445 ENSG00000269335 HEK293_OSMI2_2hA HEK293_TMG_2hB IKBKG protein_coding retained_intron 30.47362 53.4979 13.54452 4.259322 0.4547829 -1.980978 3.022361 2.843101 2.160666 0.5383014 0.1682314 -0.394393 0.11947500 0.05246667 0.15910000 0.1066333 1.636286e-08 1.66243e-24 TRUE TRUE
ENST00000689906 ENSG00000269335 HEK293_OSMI2_2hA HEK293_TMG_2hB IKBKG protein_coding protein_coding 30.47362 53.4979 13.54452 4.259322 0.4547829 -1.980978 6.378561 12.723773 4.097327 0.8349933 0.4854238 -1.632388 0.21732500 0.23840000 0.30290000 0.0645000 3.996583e-01 1.66243e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000269335 E001 0.0000000       X 154541199 154541254 56 +      
ENSG00000269335 E002 0.0000000       X 154541255 154541391 137 +      
ENSG00000269335 E003 0.0000000       X 154542244 154542262 19 +      
ENSG00000269335 E004 0.0000000       X 154542263 154542281 19 +      
ENSG00000269335 E005 0.2214452 0.0368285376 1.000000000   X 154542282 154542387 106 + 0.000 0.067 8.266
ENSG00000269335 E006 0.0000000       X 154542388 154542452 65 +      
ENSG00000269335 E007 0.1482932 0.0420164121 1.000000000   X 154545927 154546190 264 + 0.000 0.067 10.079
ENSG00000269335 E008 6.4584306 0.0062206717 0.437710080 0.579620511 X 154547347 154547358 12 + 0.866 0.754 -0.442
ENSG00000269335 E009 13.8455139 0.0015629556 0.674092269 0.779609771 X 154547359 154547385 27 + 1.022 1.068 0.167
ENSG00000269335 E010 70.2794922 0.0004179212 0.727851938 0.820442656 X 154547386 154547619 234 + 1.719 1.736 0.056
ENSG00000269335 E011 54.3631001 0.0004885761 0.058266910 0.123655635 X 154547620 154547635 16 + 1.523 1.641 0.401
ENSG00000269335 E012 49.2915759 0.0005000192 0.275431185 0.414732835 X 154547636 154547637 2 + 1.523 1.592 0.234
ENSG00000269335 E013 60.0752086 0.0004342428 0.340430993 0.484389300 X 154547638 154547640 3 + 1.619 1.673 0.183
ENSG00000269335 E014 62.4584453 0.0003912580 0.289406094 0.430090810 X 154547641 154547641 1 + 1.632 1.691 0.199
ENSG00000269335 E015 158.2245558 0.0003066097 0.644880574 0.757111926 X 154547642 154547688 47 + 2.069 2.083 0.049
ENSG00000269335 E016 143.5197902 0.0003120266 0.901576216 0.941290292 X 154547689 154547689 1 + 2.037 2.040 0.009
ENSG00000269335 E017 215.2645550 0.0002229972 0.936955120 0.964354096 X 154547690 154547745 56 + 2.215 2.211 -0.013
ENSG00000269335 E018 2.5306616 0.0760590246 0.249627603 0.385477906 X 154547847 154548089 243 + 0.620 0.404 -1.046
ENSG00000269335 E019 154.2557298 0.0002194391 0.770348011 0.851675603 X 154551988 154551990 3 + 2.078 2.066 -0.040
ENSG00000269335 E020 163.5008331 0.0002212145 0.766608277 0.849059563 X 154551991 154552002 12 + 2.087 2.096 0.028
ENSG00000269335 E021 150.2979249 0.0002416335 0.701908309 0.800862589 X 154552003 154552010 8 + 2.069 2.054 -0.051
ENSG00000269335 E022 371.8451749 0.0002679354 0.596670201 0.718580250 X 154552011 154552189 179 + 2.439 2.450 0.037
ENSG00000269335 E023 193.4288209 0.0015010220 0.099850508 0.190250611 X 154556165 154556292 128 + 2.113 2.176 0.209
ENSG00000269335 E024 94.4616976 0.0117545105 0.701607497 0.800697796 X 154556293 154556376 84 + 1.876 1.858 -0.063
ENSG00000269335 E025 0.4482035 0.0410081005 0.004579263 0.014762658 X 154556377 154556539 163 + 0.463 0.000 -14.735
ENSG00000269335 E026 0.1482932 0.0420164121 1.000000000   X 154556540 154556860 321 + 0.000 0.067 10.079
ENSG00000269335 E027 18.8821554 0.0164485588 0.070060893 0.143468296 X 154558532 154558534 3 + 1.341 1.151 -0.671
ENSG00000269335 E028 60.7083353 0.0004772039 0.005001642 0.015934250 X 154558535 154558650 116 + 1.792 1.643 -0.506
ENSG00000269335 E029 8.5117403 0.0351446766 0.000342032 0.001548351 X 154558651 154558706 56 + 1.228 0.730 -1.865
ENSG00000269335 E030 0.4782907 0.0242936242 0.567134084 0.694002037 X 154559467 154559523 57 + 0.000 0.176 11.793
ENSG00000269335 E031 7.9092701 0.0022327800 0.880533925 0.927365524 X 154560407 154560559 153 + 0.827 0.846 0.074
ENSG00000269335 E032 0.3634088 0.3521095089 1.000000000   X 154560560 154560736 177 + 0.000 0.126 10.368
ENSG00000269335 E033 34.1057754 0.0006374791 0.024765412 0.061394047 X 154561688 154561763 76 + 1.555 1.399 -0.538
ENSG00000269335 E034 9.1750256 0.0350170918 0.664396465 0.772219498 X 154561764 154561784 21 + 0.966 0.899 -0.253
ENSG00000269335 E035 2.4033595 0.0068167897 0.207251575 0.335228413 X 154561785 154562809 1025 + 0.620 0.398 -1.079
ENSG00000269335 E036 19.1384404 0.0035958607 0.267562556 0.405896130 X 154562810 154562953 144 + 1.273 1.167 -0.375
ENSG00000269335 E037 6.3335035 0.0026551224 0.578559729 0.703619997 X 154563559 154563701 143 + 0.682 0.767 0.347
ENSG00000269335 E038 0.1817044 0.0392939025 1.000000000   X 154563702 154563958 257 + 0.000 0.067 10.102
ENSG00000269335 E039 0.9889485 0.0522391604 0.810276677 0.879596175 X 154563959 154564020 62 + 0.213 0.263 0.389
ENSG00000269335 E040 0.0000000       X 154564021 154564221 201 +      
ENSG00000269335 E041 1.1780267 0.0139348469 0.144050154 0.253526719 X 154564319 154565046 728 + 0.000 0.336 13.089