ENSG00000269293

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000602810 ENSG00000269293 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN16-AS1 lncRNA lncRNA 22.33009 42.48542 10.74988 0.8630828 0.238539 -1.981646 1.9923345 2.1618491 1.0260640 0.2187034 0.09823752 -1.0678108 0.10695000 0.05113333 0.09513333 0.04400000 2.011297e-02 8.940431e-08 FALSE FALSE
MSTRG.27872.12 ENSG00000269293 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN16-AS1 lncRNA   22.33009 42.48542 10.74988 0.8630828 0.238539 -1.981646 7.2081331 18.9148471 2.1822958 0.2824478 0.66271545 -3.1097672 0.24087917 0.44566667 0.20360000 -0.24206667 2.423412e-02 8.940431e-08 TRUE FALSE
MSTRG.27872.15 ENSG00000269293 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN16-AS1 lncRNA   22.33009 42.48542 10.74988 0.8630828 0.238539 -1.981646 5.5893286 10.4444430 1.4714699 0.3347978 0.34967273 -2.8190150 0.24449583 0.24600000 0.13746667 -0.10853333 1.305797e-01 8.940431e-08 TRUE FALSE
MSTRG.27872.2 ENSG00000269293 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN16-AS1 lncRNA   22.33009 42.48542 10.74988 0.8630828 0.238539 -1.981646 1.2064661 1.2763688 1.5855097 0.1527868 0.41221224 0.3107131 0.07040417 0.03006667 0.14740000 0.11733333 1.004653e-03 8.940431e-08 TRUE TRUE
MSTRG.27872.4 ENSG00000269293 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN16-AS1 lncRNA   22.33009 42.48542 10.74988 0.8630828 0.238539 -1.981646 0.9630831 0.8875071 1.1448794 0.2147058 0.08406024 0.3637469 0.05887500 0.02076667 0.10650000 0.08573333 8.940431e-08 8.940431e-08   TRUE
MSTRG.27872.5 ENSG00000269293 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN16-AS1 lncRNA   22.33009 42.48542 10.74988 0.8630828 0.238539 -1.981646 0.5931935 0.2287069 0.5993362 0.1183407 0.10279486 1.3519980 0.03708333 0.00540000 0.05560000 0.05020000 7.361007e-03 8.940431e-08 FALSE FALSE
MSTRG.27872.9 ENSG00000269293 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN16-AS1 lncRNA   22.33009 42.48542 10.74988 0.8630828 0.238539 -1.981646 2.4003754 4.2627578 1.3935679 0.5852997 0.24420594 -1.6060687 0.12574583 0.09983333 0.12913333 0.02930000 6.315377e-01 8.940431e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000269293 E001 1.0266130 0.0125589837 9.497510e-01 9.725600e-01 6 28015122 28015737 616 - 0.230 0.245 0.123
ENSG00000269293 E002 0.1515154 0.0419068832 9.260727e-02   6 28016360 28017201 842 - 0.230 0.000 -11.525
ENSG00000269293 E003 1.8435995 0.1030947771 4.320569e-03 1.404290e-02 6 28060378 28060488 111 - 0.769 0.209 -2.984
ENSG00000269293 E004 21.8421325 0.0011806080 1.895969e-13 5.186796e-12 6 28090946 28091098 153 - 1.646 1.077 -1.984
ENSG00000269293 E005 14.7201516 0.0041280384 7.886562e-09 9.909658e-08 6 28091099 28091147 49 - 1.471 0.919 -1.972
ENSG00000269293 E006 36.3882808 0.0006192650 1.561486e-21 1.183276e-19 6 28091148 28091388 241 - 1.862 1.284 -1.979
ENSG00000269293 E007 24.7121124 0.0007971928 3.617398e-21 2.648011e-19 6 28091389 28091468 80 - 1.754 1.082 -2.331
ENSG00000269293 E008 8.8830113 0.0201940738 7.759279e-03 2.317289e-02 6 28116182 28116212 31 - 1.154 0.798 -1.326
ENSG00000269293 E009 14.4276320 0.0323735379 8.679019e-02 1.702667e-01 6 28116213 28116302 90 - 1.248 1.015 -0.839
ENSG00000269293 E010 10.6540929 0.0016410664 6.125897e-01 7.314953e-01 6 28116303 28116348 46 - 1.003 0.934 -0.257
ENSG00000269293 E011 15.0544453 0.0028619807 9.114492e-04 3.654033e-03 6 28116349 28116451 103 - 1.341 1.011 -1.178
ENSG00000269293 E012 1.2209898 0.0104669599 7.948667e-01 8.689725e-01 6 28119782 28120476 695 - 0.230 0.281 0.386
ENSG00000269293 E013 0.3299976 0.0274424043 1.000000e+00   6 28120477 28120512 36 - 0.000 0.115 8.847
ENSG00000269293 E014 7.2329228 0.0023614463 1.479029e-04 7.380226e-04 6 28120513 28120517 5 - 1.154 0.681 -1.803
ENSG00000269293 E015 15.7387969 0.0011995499 3.480652e-08 3.870381e-07 6 28120518 28120676 159 - 1.471 0.971 -1.776
ENSG00000269293 E016 1.1124400 0.0115641249 2.309099e-03 8.180034e-03 6 28120677 28121794 1118 - 0.652 0.115 -3.521
ENSG00000269293 E017 0.0000000       6 28121795 28121797 3 -      
ENSG00000269293 E018 15.5170408 0.0440259461 1.513886e-02 4.079966e-02 6 28121798 28122271 474 - 1.342 1.006 -1.197
ENSG00000269293 E019 5.6496531 0.0141614130 7.072755e-03 2.141530e-02 6 28122272 28122280 9 - 1.003 0.607 -1.573
ENSG00000269293 E020 22.0867914 0.0009166071 4.169058e-02 9.417029e-02 6 28122281 28122375 95 - 1.380 1.197 -0.644
ENSG00000269293 E021 82.7422158 0.0003714148 8.550332e-01 9.103455e-01 6 28122376 28122640 265 - 1.785 1.787 0.007
ENSG00000269293 E022 36.7971106 0.0212793146 1.407993e-02 3.840493e-02 6 28122641 28123018 378 - 1.632 1.388 -0.837
ENSG00000269293 E023 114.6489795 0.0013648730 4.647639e-03 1.495230e-02 6 28123019 28123083 65 - 1.809 1.940 0.442
ENSG00000269293 E024 509.7829974 0.0001327167 8.088238e-07 6.850377e-06 6 28123084 28123208 125 - 2.490 2.580 0.300
ENSG00000269293 E025 328.2590832 0.0001541064 1.294755e-06 1.049897e-05 6 28123209 28123211 3 - 2.274 2.393 0.397
ENSG00000269293 E026 1.0350190 0.0251949666 9.551597e-01 9.758567e-01 6 28125049 28125101 53 - 0.230 0.245 0.122
ENSG00000269293 E027 6.6664367 0.0026106464 4.870743e-01 6.247784e-01 6 28125623 28125819 197 - 0.862 0.756 -0.416
ENSG00000269293 E028 6.7294877 0.0711221637 1.247510e-01 2.267804e-01 6 28136024 28136744 721 - 1.004 0.714 -1.123
ENSG00000269293 E029 402.3444983 0.0001753171 4.188831e-05 2.402984e-04 6 28136745 28136753 9 - 2.391 2.477 0.287
ENSG00000269293 E030 503.6819450 0.0001503239 1.256364e-02 3.488190e-02 6 28136754 28137313 560 - 2.527 2.568 0.136