ENSG00000268388

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000593604 ENSG00000268388 HEK293_OSMI2_2hA HEK293_TMG_2hB FENDRR lncRNA lncRNA 2.143245 1.962089 2.764824 0.2066804 0.09015391 0.4926713 0.42145417 0.23535337 0.6985581 0.09380252 0.14710969 1.5300251 0.20675417 0.127900000 0.24983333 0.12193333 0.3937371928 0.0009631514 FALSE TRUE
ENST00000595886 ENSG00000268388 HEK293_OSMI2_2hA HEK293_TMG_2hB FENDRR lncRNA lncRNA 2.143245 1.962089 2.764824 0.2066804 0.09015391 0.4926713 0.44977201 0.39146847 0.5092645 0.23126601 0.24374117 0.3711828 0.21790833 0.205600000 0.18743333 -0.01816667 1.0000000000 0.0009631514   FALSE
ENST00000598996 ENSG00000268388 HEK293_OSMI2_2hA HEK293_TMG_2hB FENDRR lncRNA lncRNA 2.143245 1.962089 2.764824 0.2066804 0.09015391 0.4926713 0.48772330 0.78209330 0.1486816 0.17303047 0.14868163 -2.3195353 0.24468750 0.390666667 0.05580000 -0.33486667 0.0558521593 0.0009631514 FALSE TRUE
ENST00000659025 ENSG00000268388 HEK293_OSMI2_2hA HEK293_TMG_2hB FENDRR lncRNA lncRNA 2.143245 1.962089 2.764824 0.2066804 0.09015391 0.4926713 0.06315529 0.01943103 0.1902955 0.01943103 0.11857733 2.7667202 0.02684167 0.009133333 0.06910000 0.05996667 0.5413300928 0.0009631514   FALSE
ENST00000659545 ENSG00000268388 HEK293_OSMI2_2hA HEK293_TMG_2hB FENDRR lncRNA lncRNA 2.143245 1.962089 2.764824 0.2066804 0.09015391 0.4926713 0.16881659 0.00000000 0.3837421 0.00000000 0.38374212 5.2991792 0.07514583 0.000000000 0.13030000 0.13030000 0.8815157192 0.0009631514   FALSE
ENST00000667117 ENSG00000268388 HEK293_OSMI2_2hA HEK293_TMG_2hB FENDRR lncRNA lncRNA 2.143245 1.962089 2.764824 0.2066804 0.09015391 0.4926713 0.09091983 0.39193451 0.3354241 0.23215613 0.33542413 -0.2185916 0.04092500 0.201533333 0.12586667 -0.07566667 0.6038033920 0.0009631514   FALSE
MSTRG.13183.11 ENSG00000268388 HEK293_OSMI2_2hA HEK293_TMG_2hB FENDRR lncRNA   2.143245 1.962089 2.764824 0.2066804 0.09015391 0.4926713 0.07742021 0.00000000 0.1892751 0.00000000 0.02118498 4.3166895 0.03155000 0.000000000 0.06836667 0.06836667 0.0009631514 0.0009631514 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000268388 E001 0.0000000       16 86474529 86474530 2 -      
ENSG00000268388 E002 0.2966881 0.0290785164 2.865867e-01   16 86474531 86474537 7 - 0.196 0.000 -9.602
ENSG00000268388 E003 0.2966881 0.0290785164 2.865867e-01   16 86474538 86474538 1 - 0.196 0.000 -11.997
ENSG00000268388 E004 1.2994549 0.0182893146 7.232146e-01 8.170850e-01 16 86474539 86474553 15 - 0.331 0.395 0.380
ENSG00000268388 E005 8.8442812 0.0020700654 4.150790e-01 5.585025e-01 16 86474554 86474702 149 - 0.953 1.042 0.328
ENSG00000268388 E006 17.5414890 0.0169258853 1.145760e-01 2.122221e-01 16 86474703 86474933 231 - 1.192 1.354 0.571
ENSG00000268388 E007 4.5819801 0.0046735879 2.232136e-01 3.542291e-01 16 86474934 86474941 8 - 0.673 0.841 0.678
ENSG00000268388 E008 41.0227667 0.0005546601 5.040642e-01 6.399681e-01 16 86474942 86475842 901 - 1.641 1.610 -0.107
ENSG00000268388 E009 8.2093695 0.0022343512 1.903232e-01 3.141793e-01 16 86475843 86475898 56 - 1.029 0.886 -0.536
ENSG00000268388 E010 10.1269798 0.0018339279 6.295214e-02 1.316346e-01 16 86475899 86476024 126 - 1.132 0.944 -0.686
ENSG00000268388 E011 21.8815080 0.0009385825 7.444017e-02 1.506416e-01 16 86476025 86476655 631 - 1.416 1.292 -0.434
ENSG00000268388 E012 20.3796266 0.0010565463 2.355370e-03 8.324959e-03 16 86476656 86477123 468 - 1.426 1.200 -0.789
ENSG00000268388 E013 7.2588040 0.0822835355 6.280548e-02 1.313845e-01 16 86477124 86477199 76 - 1.051 0.706 -1.330
ENSG00000268388 E014 5.8624609 0.0342361433 1.102689e-01 2.059459e-01 16 86477886 86478051 166 - 0.939 0.704 -0.921
ENSG00000268388 E015 1.4340185 0.0097343727 9.576636e-01 9.774607e-01 16 86478052 86478132 81 - 0.385 0.395 0.059
ENSG00000268388 E016 1.5458817 0.0105625203 1.221634e-01 2.230267e-01 16 86478701 86478704 4 - 0.516 0.241 -1.618
ENSG00000268388 E017 2.6143145 0.0058415931 8.822337e-02 1.724141e-01 16 86478705 86478756 52 - 0.673 0.395 -1.319
ENSG00000268388 E018 0.8783198 0.0140901700 9.797732e-02 1.874261e-01 16 86485632 86485746 115 - 0.109 0.396 2.382
ENSG00000268388 E019 0.9328370 0.2952035703 7.716554e-01 8.526096e-01 16 86487706 86487717 12 - 0.270 0.320 0.338
ENSG00000268388 E020 0.9264943 0.0139807493 7.595758e-01 8.439037e-01 16 86487718 86487736 19 - 0.268 0.325 0.379
ENSG00000268388 E021 62.1403451 0.0006369713 5.872106e-09 7.572859e-08 16 86487737 86489732 1996 - 1.674 1.911 0.802
ENSG00000268388 E022 16.9800916 0.0174312118 1.034309e-01 1.957125e-01 16 86489733 86490182 450 - 1.175 1.335 0.562
ENSG00000268388 E023 4.8933528 0.1847831672 4.715856e-01 6.106872e-01 16 86490183 86490225 43 - 0.721 0.818 0.386
ENSG00000268388 E024 3.6032593 0.2077478745 1.650647e-01 2.817792e-01 16 86490226 86490263 38 - 0.515 0.787 1.173
ENSG00000268388 E025 16.9786222 0.0011017714 9.714334e-01 9.861438e-01 16 86490264 86490513 250 - 1.258 1.257 -0.002
ENSG00000268388 E026 6.4194298 0.0027738607 1.220011e-01 2.227841e-01 16 86490514 86490852 339 - 0.953 0.765 -0.726
ENSG00000268388 E027 13.4164284 0.0015203539 1.393021e-02 3.806498e-02 16 86490853 86491004 152 - 1.251 1.028 -0.801
ENSG00000268388 E028 0.1451727 0.0427274348 6.295763e-01   16 86498424 86498585 162 - 0.109 0.000 -11.031
ENSG00000268388 E029 10.9389188 0.0141453531 2.009477e-01 3.273678e-01 16 86508655 86509099 445 - 1.141 0.996 -0.525