ENSG00000267680

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336976 ENSG00000267680 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF224 protein_coding protein_coding 5.174468 1.337595 7.341249 0.2805705 0.2528696 2.447602 0.41793251 0.3551754 0.0000000 0.23256750 0.00000000 -5.190518 0.13131250 0.28486667 0.0000000 -0.28486667 0.061380236 0.001276674 FALSE TRUE
ENST00000589060 ENSG00000267680 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF224 protein_coding retained_intron 5.174468 1.337595 7.341249 0.2805705 0.2528696 2.447602 0.98436076 0.1916206 1.3390762 0.08134652 0.02575861 2.742257 0.16837917 0.13180000 0.1826667 0.05086667 0.563359899 0.001276674   FALSE
ENST00000589870 ENSG00000267680 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF224 protein_coding protein_coding 5.174468 1.337595 7.341249 0.2805705 0.2528696 2.447602 0.77546481 0.1469452 1.2101590 0.09317216 0.13246795 2.958736 0.14613750 0.09243333 0.1642667 0.07183333 0.450691826 0.001276674   FALSE
ENST00000590614 ENSG00000267680 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF224 protein_coding retained_intron 5.174468 1.337595 7.341249 0.2805705 0.2528696 2.447602 0.34884529 0.0000000 0.6638852 0.00000000 0.11181929 6.074431 0.05258333 0.00000000 0.0896000 0.08960000 0.001276674 0.001276674   FALSE
ENST00000591511 ENSG00000267680 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF224 protein_coding protein_coding 5.174468 1.337595 7.341249 0.2805705 0.2528696 2.447602 1.02634075 0.0000000 1.1095330 0.00000000 0.36003914 6.806753 0.20622500 0.00000000 0.1481333 0.14813333 0.003066907 0.001276674 FALSE TRUE
ENST00000684943 ENSG00000267680 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF224 protein_coding protein_coding 5.174468 1.337595 7.341249 0.2805705 0.2528696 2.447602 0.03123223 0.2498579 0.0000000 0.24985786 0.00000000 -4.699651 0.03116250 0.24930000 0.0000000 -0.24930000 0.610156784 0.001276674 FALSE TRUE
ENST00000693561 ENSG00000267680 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF224 protein_coding protein_coding 5.174468 1.337595 7.341249 0.2805705 0.2528696 2.447602 1.48598170 0.3650021 2.8951465 0.29472941 0.27224409 2.953640 0.24556250 0.21560000 0.3979000 0.18230000 0.547706560 0.001276674 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000267680 E001 1.4705276 0.078769457 0.1032384010 0.195404236 19 44094361 44094386 26 + 0.375 0.000 -16.545
ENSG00000267680 E002 1.6220431 0.017026297 0.0662623173 0.137158935 19 44094387 44094389 3 + 0.399 0.000 -16.682
ENSG00000267680 E003 1.6220431 0.017026297 0.0662623173 0.137158935 19 44094390 44094391 2 + 0.399 0.000 -16.682
ENSG00000267680 E004 9.9033510 0.002069973 0.0845758323 0.166718391 19 44094392 44094488 97 + 0.945 0.807 -0.531
ENSG00000267680 E005 9.5649450 0.051408987 0.2905550176 0.431378634 19 44094489 44094530 42 + 0.917 0.865 -0.199
ENSG00000267680 E006 9.0948974 0.001908124 0.2819215309 0.421876857 19 44094531 44094784 254 + 0.903 0.856 -0.178
ENSG00000267680 E007 12.0344957 0.001539270 0.0328303329 0.077470082 19 44094785 44095158 374 + 1.031 0.856 -0.656
ENSG00000267680 E008 11.9272986 0.001627135 0.0798483916 0.159328991 19 44095159 44095941 783 + 1.020 0.901 -0.444
ENSG00000267680 E009 5.8495265 0.002886244 0.9887041852 0.996971629 19 44096046 44096342 297 + 0.709 0.807 0.395
ENSG00000267680 E010 14.4850622 0.001385542 0.0597190368 0.126146087 19 44096343 44096431 89 + 1.093 0.978 -0.421
ENSG00000267680 E011 2.5311356 0.010114957 0.0155808725 0.041802971 19 44097709 44097805 97 + 0.523 0.000 -17.311
ENSG00000267680 E012 17.9013989 0.001040827 0.1451395310 0.255027025 19 44097806 44097888 83 + 1.168 1.126 -0.149
ENSG00000267680 E013 19.2777849 0.001012834 0.0169263577 0.044771200 19 44100801 44100927 127 + 1.214 1.073 -0.506
ENSG00000267680 E014 1.9209213 0.007339238 0.0391528945 0.089464333 19 44100928 44101088 161 + 0.444 0.000 -16.923
ENSG00000267680 E015 17.6569102 0.001273523 0.3948632046 0.538693332 19 44101133 44101225 93 + 1.151 1.173 0.080
ENSG00000267680 E016 0.8114974 0.073624586 0.0051573549 0.016356605 19 44105333 44106395 1063 + 0.056 0.609 4.484
ENSG00000267680 E017 217.7755138 0.030812173 0.0006094894 0.002567678 19 44106396 44109886 3491 + 2.172 2.402 0.768