ENSG00000267106

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000585797 ENSG00000267106 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF561-AS1 lncRNA lncRNA 4.44795 5.673083 4.911658 0.5145421 0.3770506 -0.2075294 0.8356008 1.7221326 0.9177970 0.1390932 0.31135816 -0.9006683 0.19295000 0.3053000 0.17896667 -0.12633333 3.268971e-01 5.708189e-05    
ENST00000586614 ENSG00000267106 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF561-AS1 lncRNA lncRNA 4.44795 5.673083 4.911658 0.5145421 0.3770506 -0.2075294 0.1321239 0.0000000 0.3341826 0.0000000 0.09123585 5.1051021 0.02784167 0.0000000 0.06926667 0.06926667 5.708189e-05 5.708189e-05 TRUE  
ENST00000686891 ENSG00000267106 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF561-AS1 lncRNA lncRNA 4.44795 5.673083 4.911658 0.5145421 0.3770506 -0.2075294 0.3881508 0.5642071 0.1532962 0.2831979 0.15329621 -1.8140799 0.08048333 0.1094333 0.03676667 -0.07266667 5.939970e-01 5.708189e-05    
MSTRG.16381.10 ENSG00000267106 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF561-AS1 lncRNA   4.44795 5.673083 4.911658 0.5145421 0.3770506 -0.2075294 1.9990413 2.8829840 2.5826147 0.7046680 0.53061380 -0.1581505 0.44386667 0.4954000 0.51480000 0.01940000 9.773394e-01 5.708189e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000267106 E001 0.0000000       19 9621249 9621262 14 +      
ENSG00000267106 E002 0.0000000       19 9621263 9621266 4 +      
ENSG00000267106 E003 0.1817044 0.0420599375 0.606765197   19 9621267 9621277 11 + 0.000 0.108 10.334
ENSG00000267106 E004 0.1817044 0.0420599375 0.606765197   19 9621278 9621278 1 + 0.000 0.108 12.493
ENSG00000267106 E005 0.9201516 0.0138707566 0.733085677 0.824380337 19 9621279 9621309 31 + 0.327 0.266 -0.411
ENSG00000267106 E006 0.9201516 0.0138707566 0.733085677 0.824380337 19 9621310 9621313 4 + 0.327 0.266 -0.411
ENSG00000267106 E007 1.0684447 0.0135044011 0.998010750 1.000000000 19 9621314 9621350 37 + 0.327 0.328 0.003
ENSG00000267106 E008 0.3697384 0.0248988643 0.282603977 0.422626908 19 9621351 9621416 66 + 0.000 0.195 13.452
ENSG00000267106 E009 0.0000000       19 9621478 9621481 4 +      
ENSG00000267106 E010 0.0000000       19 9621482 9621486 5 +      
ENSG00000267106 E011 0.2998086 0.0278924022 0.842205916   19 9621487 9621502 16 + 0.138 0.108 -0.412
ENSG00000267106 E012 0.4481018 0.0325809303 0.748795475 0.835925555 19 9621503 9621504 2 + 0.138 0.194 0.585
ENSG00000267106 E013 1.0403321 0.0133131110 0.454937481 0.595511141 19 9621505 9621511 7 + 0.398 0.266 -0.828
ENSG00000267106 E014 1.0403321 0.0133131110 0.454937481 0.595511141 19 9621512 9621516 5 + 0.398 0.266 -0.828
ENSG00000267106 E015 5.2922129 0.0291174684 0.814519602 0.882497942 19 9621517 9621532 16 + 0.821 0.798 -0.092
ENSG00000267106 E016 7.7078922 0.0022885588 0.849236918 0.906420403 19 9621533 9621543 11 + 0.929 0.949 0.075
ENSG00000267106 E017 8.5279104 0.0020423119 0.959274047 0.978457918 19 9621544 9621548 5 + 0.983 0.976 -0.027
ENSG00000267106 E018 12.3758089 0.0014796268 0.686522132 0.789028777 19 9621549 9621564 16 + 1.101 1.137 0.127
ENSG00000267106 E019 27.7393519 0.0007235709 0.351808524 0.496021878 19 9621565 9621645 81 + 1.417 1.474 0.196
ENSG00000267106 E020 12.7504696 0.0015051060 0.655003045 0.765009475 19 9626784 9626802 19 + 1.161 1.118 -0.154
ENSG00000267106 E021 19.7088425 0.0009663447 0.524652546 0.658119745 19 9626803 9626860 58 + 1.342 1.293 -0.173
ENSG00000267106 E022 0.1472490 0.0434785460 0.387357849   19 9626861 9626902 42 + 0.138 0.000 -14.086
ENSG00000267106 E023 0.1472490 0.0434785460 0.387357849   19 9626903 9627043 141 + 0.138 0.000 -14.086
ENSG00000267106 E024 0.4396707 0.0317156417 0.052432784 0.113490244 19 9627044 9627625 582 + 0.327 0.000 -15.532
ENSG00000267106 E025 0.1482932 0.0411597534 0.611157221   19 9627626 9627712 87 + 0.000 0.108 12.492
ENSG00000267106 E026 0.4407149 0.0230923278 0.419676610 0.562933493 19 9627713 9627715 3 + 0.243 0.108 -1.411
ENSG00000267106 E027 2.6593659 0.0154236301 0.027363385 0.066733309 19 9627716 9627772 57 + 0.740 0.382 -1.673
ENSG00000267106 E028 2.2154287 0.0397245868 0.142015875 0.250796837 19 9627773 9627774 2 + 0.641 0.382 -1.258
ENSG00000267106 E029 2.6667528 0.0414985076 0.104049657 0.196676432 19 9627775 9627806 32 + 0.710 0.430 -1.289
ENSG00000267106 E030 1.8048908 0.0096082700 0.051280432 0.111435238 19 9627807 9632227 4421 + 0.602 0.267 -1.822
ENSG00000267106 E031 70.1574478 0.0006527378 0.055841726 0.119417167 19 9632228 9632417 190 + 1.801 1.873 0.242
ENSG00000267106 E032 0.9631146 0.0140885425 0.251905160 0.388210175 19 9632418 9633459 1042 + 0.398 0.194 -1.409
ENSG00000267106 E033 56.3796007 0.0004740575 0.039595346 0.090282594 19 9633460 9633592 133 + 1.700 1.788 0.297
ENSG00000267106 E034 81.7451796 0.0036015767 0.160456232 0.275735891 19 9633593 9635446 1854 + 1.879 1.928 0.166
ENSG00000267106 E035 3.3674322 0.0048644298 0.679208534 0.783479786 19 9645074 9645189 116 + 0.677 0.613 -0.273
ENSG00000267106 E036 2.3207349 0.0393222834 0.007752814 0.023157960 19 9645190 9646002 813 + 0.740 0.267 -2.407
ENSG00000267106 E037 2.0347696 0.0070542696 0.014256404 0.038809196 19 9646096 9647203 1108 + 0.677 0.267 -2.146
ENSG00000267106 E038 3.4416179 0.0047856685 0.135292423 0.241523766 19 9648328 9648991 664 + 0.769 0.549 -0.941
ENSG00000267106 E039 8.3730161 0.0085239190 0.013149363 0.036254326 19 9648992 9651892 2901 + 1.114 0.823 -1.087
ENSG00000267106 E040 2.6053438 0.0320169656 0.002150498 0.007691685 19 9651893 9653090 1198 + 0.796 0.266 -2.635
ENSG00000267106 E041 1.0479225 0.2217576208 0.009681228 0.027977245 19 9653091 9653258 168 + 0.561 0.000 -16.198
ENSG00000267106 E042 0.8136755 0.0146200737 0.453705179 0.594442461 19 9653259 9653880 622 + 0.327 0.195 -0.994
ENSG00000267106 E043 0.9964241 0.0127159811 0.628546746 0.744082681 19 9672802 9672914 113 + 0.243 0.328 0.590
ENSG00000267106 E044 0.6997360 0.0167355697 0.067486216 0.139170760 19 9674635 9674662 28 + 0.000 0.328 14.345