ENSG00000266865

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000580190 ENSG00000266865 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 2.201017 2.58352 0.3207517 0.1777491 0.2302016 0.17604339 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.05633750 0.00000000 0.00000000 0.000000000   0.0055448 FALSE TRUE
ENST00000687724 ENSG00000266865 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 2.201017 2.58352 0.3207517 0.1777491 0.2302016 0.41806804 0.59948269 0.57114684 0.26798450 0.22759868 -0.06868251 0.18362500 0.25810000 0.22816667 -0.029933333 0.9196295 0.0055448 TRUE FALSE
ENST00000690641 ENSG00000266865 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 2.201017 2.58352 0.3207517 0.1777491 0.2302016 0.23391626 0.07139994 0.29476276 0.03571707 0.06396490 1.90458706 0.09791667 0.03406667 0.11183333 0.077766667 0.1351569 0.0055448 TRUE FALSE
ENST00000691618 ENSG00000266865 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_unprocessed_pseudogene processed_transcript 2.359429 2.201017 2.58352 0.3207517 0.1777491 0.2302016 0.16752858 0.29982767 0.15896814 0.15381662 0.07950783 -0.87471476 0.07522083 0.15700000 0.05876667 -0.098233333 0.8063853 0.0055448 TRUE FALSE
MSTRG.14097.10 ENSG00000266865 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_unprocessed_pseudogene   2.359429 2.201017 2.58352 0.3207517 0.1777491 0.2302016 0.57961774 0.46938210 0.71509682 0.26337206 0.09125196 0.59699763 0.25203750 0.18690000 0.27560000 0.088700000 0.7154142 0.0055448   FALSE
MSTRG.14097.14 ENSG00000266865 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_unprocessed_pseudogene   2.359429 2.201017 2.58352 0.3207517 0.1777491 0.2302016 0.14751664 0.16893621 0.26685085 0.02466003 0.07029439 0.62966359 0.06417500 0.08326667 0.10163333 0.018366667 0.8929139 0.0055448 TRUE FALSE
MSTRG.14097.2 ENSG00000266865 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_unprocessed_pseudogene   2.359429 2.201017 2.58352 0.3207517 0.1777491 0.2302016 0.09680211 0.20960874 0.02326416 0.02967593 0.02326416 -2.72289505 0.04232500 0.09826667 0.01006667 -0.088200000 0.0055448 0.0055448 TRUE FALSE
MSTRG.14097.3 ENSG00000266865 HEK293_OSMI2_2hA HEK293_TMG_2hB transcribed_unprocessed_pseudogene   2.359429 2.201017 2.58352 0.3207517 0.1777491 0.2302016 0.27921151 0.31831917 0.39081170 0.11283582 0.08867732 0.28782562 0.12128333 0.15823333 0.15410000 -0.004133333 0.9958473 0.0055448 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000266865 E001 0.0000000       17 31007813 31007944 132 +      
ENSG00000266865 E002 0.0000000       17 31007945 31008069 125 +      
ENSG00000266865 E003 5.8603144 0.0029086024 0.1947097874 0.319632469 17 31008070 31008496 427 + 0.735 0.894 0.624
ENSG00000266865 E004 4.2090049 0.0262184968 0.3743568319 0.518779396 17 31008497 31008534 38 + 0.645 0.774 0.534
ENSG00000266865 E005 3.7984935 0.0402707943 0.3861272797 0.530323155 17 31008535 31008571 37 + 0.610 0.748 0.582
ENSG00000266865 E006 2.4229670 0.0072743497 0.5360003164 0.667791133 17 31008572 31008575 4 + 0.484 0.579 0.449
ENSG00000266865 E007 2.6444122 0.0058290590 0.3992578416 0.542995697 17 31008576 31008578 3 + 0.484 0.613 0.602
ENSG00000266865 E008 3.5613295 0.0073318488 0.8089828527 0.878675013 17 31008579 31008604 26 + 0.644 0.674 0.127
ENSG00000266865 E009 5.8099671 0.0179716197 0.9209633630 0.954121522 17 31008605 31008641 37 + 0.832 0.838 0.022
ENSG00000266865 E010 6.5171666 0.0047436964 0.8138054065 0.881986435 17 31008642 31008662 21 + 0.893 0.858 -0.135
ENSG00000266865 E011 6.8180193 0.0027577807 0.9531528151 0.974705229 17 31008663 31008673 11 + 0.893 0.894 0.002
ENSG00000266865 E012 12.4099487 0.0015167634 0.6318393554 0.746799870 17 31008674 31008753 80 + 1.100 1.138 0.135
ENSG00000266865 E013 13.1829279 0.0014856568 0.7295112746 0.821682575 17 31008754 31008803 50 + 1.166 1.128 -0.135
ENSG00000266865 E014 0.0000000       17 31012921 31012956 36 +      
ENSG00000266865 E015 1.4112019 0.0337648668 0.5637844998 0.691215318 17 31016895 31017003 109 + 0.306 0.408 0.606
ENSG00000266865 E016 2.8366912 0.1470951026 0.0713579028 0.145589211 17 31021049 31021162 114 + 0.761 0.354 -1.922
ENSG00000266865 E017 25.2763096 0.0008728734 0.7964654698 0.870087672 17 31021910 31022042 133 + 1.407 1.418 0.035
ENSG00000266865 E018 5.5124468 0.0800086365 0.0004449178 0.001947153 17 31022043 31023605 1563 + 1.065 0.406 -2.776
ENSG00000266865 E019 6.2213743 0.0337372637 0.5525459532 0.681823885 17 31023606 31023631 26 + 0.894 0.801 -0.358
ENSG00000266865 E020 12.9907693 0.0260687509 0.5734600130 0.699393434 17 31023632 31023760 129 + 1.176 1.100 -0.273
ENSG00000266865 E021 4.9614513 0.0037477869 0.0020654390 0.007427418 17 31023761 31024340 580 + 0.963 0.542 -1.721
ENSG00000266865 E022 1.4779265 0.0197932166 0.1689030396 0.286750254 17 31024341 31024376 36 + 0.530 0.285 -1.362
ENSG00000266865 E023 26.2546239 0.0007374767 0.8134015730 0.881689999 17 31024377 31024426 50 + 1.425 1.433 0.029
ENSG00000266865 E024 0.1515154 0.0426689565 0.4555781255   17 31029389 31029471 83 + 0.127 0.000 -8.896
ENSG00000266865 E025 12.8087591 0.0245721735 0.6301159412 0.745347735 17 31031560 31031682 123 + 1.155 1.102 -0.192
ENSG00000266865 E026 0.0000000       17 31031881 31031946 66 +      
ENSG00000266865 E027 26.2824388 0.0008456650 0.2830658219 0.423139561 17 31032426 31032506 81 + 1.467 1.391 -0.261
ENSG00000266865 E028 6.5547701 0.0321815324 0.9249565706 0.956747660 17 31033295 31033365 71 + 0.893 0.874 -0.075
ENSG00000266865 E029 25.7066733 0.0011187445 0.3971145225 0.540893370 17 31033924 31034285 362 + 1.384 1.433 0.171
ENSG00000266865 E030 42.4016027 0.0030086366 0.0013207207 0.005046111 17 31034286 31035654 1369 + 1.524 1.695 0.583
ENSG00000266865 E031 0.0000000       17 31045407 31045409 3 +      
ENSG00000266865 E032 1.1342099 0.0248914485 0.6396418611 0.752995307 17 31045410 31045549 140 + 0.374 0.286 -0.548
ENSG00000266865 E033 0.2955422 0.0290635511 0.9545315249   17 31045550 31045937 388 + 0.127 0.117 -0.137
ENSG00000266865 E034 0.9482522 0.1591550835 0.4271091494 0.569941164 17 31071912 31072049 138 + 0.373 0.210 -1.127
ENSG00000266865 E035 0.0000000       17 31091604 31091707 104 +      
ENSG00000266865 E036 0.0000000       17 31092876 31093127 252 +