ENSG00000266412

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000581486 ENSG00000266412 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA4 protein_coding protein_coding 33.56877 14.0891 50.16515 2.764801 0.9552746 1.83137 29.730265 13.36797 43.545125 2.473595 1.6069411 1.702984 0.9111792 0.9532667 0.8678333 -0.08543333 2.061380e-01 4.276408e-13 FALSE  
MSTRG.3920.3 ENSG00000266412 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA4 protein_coding   33.56877 14.0891 50.16515 2.764801 0.9552746 1.83137 2.003687 0.00000 3.676569 0.000000 0.5769307 8.526135 0.0367250 0.0000000 0.0732000 0.07320000 4.276408e-13 4.276408e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000266412 E001 758.8351456 0.0060317247 3.414423e-15 1.204118e-13 10 46005088 46006070 983 - 2.716 3.041 1.082
ENSG00000266412 E002 96.8546746 0.0051893310 1.339452e-10 2.316129e-09 10 46006071 46006124 54 - 1.809 2.177 1.235
ENSG00000266412 E003 141.8598735 0.0073160178 1.495224e-01 2.610166e-01 10 46006125 46006172 48 - 2.068 2.182 0.381
ENSG00000266412 E004 194.5817810 0.0019768256 4.989729e-01 6.353435e-01 10 46006173 46006294 122 - 2.218 2.290 0.237
ENSG00000266412 E005 185.2894087 0.0002646932 8.061389e-01 8.767774e-01 10 46006295 46006377 83 - 2.202 2.264 0.205
ENSG00000266412 E006 153.4184188 0.0002319453 9.125680e-01 9.485790e-01 10 46006378 46006411 34 - 2.122 2.179 0.192
ENSG00000266412 E007 118.4138002 0.0002610815 5.623164e-01 6.899601e-01 10 46006412 46006426 15 - 2.005 2.080 0.251
ENSG00000266412 E008 288.9828084 0.0002179478 7.895807e-03 2.351649e-02 10 46006427 46006597 171 - 2.379 2.494 0.384
ENSG00000266412 E009 1.3683431 0.0091586477 3.115647e-01 4.540279e-01 10 46009124 46009212 89 - 0.381 0.205 -1.220
ENSG00000266412 E010 238.2338532 0.0002158236 1.463642e-02 3.967641e-02 10 46009411 46009547 137 - 2.295 2.411 0.386
ENSG00000266412 E011 95.9817845 0.0007790526 7.142698e-01 8.105207e-01 10 46009548 46009551 4 - 1.927 1.966 0.130
ENSG00000266412 E012 889.6667191 0.0004213228 1.178924e-05 7.705487e-05 10 46010223 46011206 984 - 2.901 2.885 -0.051
ENSG00000266412 E013 243.4825817 0.0009501619 6.191452e-10 9.549394e-09 10 46012883 46013026 144 - 2.367 2.227 -0.465
ENSG00000266412 E014 214.7703500 0.0016548862 8.615474e-14 2.471121e-12 10 46013550 46013639 90 - 2.327 2.107 -0.736
ENSG00000266412 E015 246.4678129 0.0005767732 2.395865e-16 9.843622e-15 10 46014444 46014552 109 - 2.382 2.191 -0.638
ENSG00000266412 E016 195.0860890 0.0001984144 9.831417e-11 1.736465e-09 10 46014854 46014930 77 - 2.274 2.130 -0.482
ENSG00000266412 E017 116.6506559 0.0002901581 1.011700e-03 3.998989e-03 10 46014931 46014942 12 - 2.037 1.964 -0.244
ENSG00000266412 E018 251.0593979 0.0001858636 1.068862e-08 1.310887e-07 10 46015126 46015266 141 - 2.372 2.274 -0.327
ENSG00000266412 E019 224.9344390 0.0002427442 4.497695e-07 4.015244e-06 10 46016540 46016694 155 - 2.322 2.233 -0.297
ENSG00000266412 E020 0.9275265 0.0146756034 6.449833e-01 7.572049e-01 10 46019323 46019537 215 - 0.231 0.343 0.779
ENSG00000266412 E021 4.5306652 0.0492696579 8.573861e-01 9.119295e-01 10 46023330 46023455 126 - 0.687 0.761 0.306
ENSG00000266412 E022 0.7792333 0.0262504560 8.409186e-01 9.007203e-01 10 46027432 46027528 97 - 0.231 0.205 -0.220
ENSG00000266412 E023 132.1257702 0.0002423880 5.994059e-05 3.311529e-04 10 46030526 46030664 139 - 2.092 1.999 -0.312