ENSG00000266338

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000488031 ENSG00000266338 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF15 protein_coding protein_coding 12.77451 9.984582 12.61395 0.5330668 0.1525604 0.3369454 1.7330873 2.0486061 1.4431653 0.2143101 0.3212876 -0.50246897 0.14050417 0.20450000 0.11383333 -0.09066667 1.073698e-01 8.111316e-07 FALSE TRUE
ENST00000577412 ENSG00000266338 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF15 protein_coding protein_coding 12.77451 9.984582 12.61395 0.5330668 0.1525604 0.3369454 2.4384838 1.5912832 3.0011504 0.2594055 0.4291515 0.91108630 0.19408750 0.15763333 0.23750000 0.07986667 2.841542e-01 8.111316e-07 FALSE TRUE
ENST00000614785 ENSG00000266338 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF15 protein_coding protein_coding 12.77451 9.984582 12.61395 0.5330668 0.1525604 0.3369454 1.3719822 1.1782013 1.5072924 0.1638099 0.7568126 0.35271987 0.10640000 0.11793333 0.11943333 0.00150000 8.950763e-01 8.111316e-07 FALSE TRUE
MSTRG.1974.10 ENSG00000266338 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF15 protein_coding   12.77451 9.984582 12.61395 0.5330668 0.1525604 0.3369454 2.9826531 2.2125364 1.7833950 0.8042510 0.4801922 -0.30951378 0.21190417 0.21613333 0.14053333 -0.07560000 6.774532e-01 8.111316e-07 FALSE TRUE
MSTRG.1974.14 ENSG00000266338 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF15 protein_coding   12.77451 9.984582 12.61395 0.5330668 0.1525604 0.3369454 0.2671732 0.0000000 1.2714366 0.0000000 0.3871529 7.00161831 0.02190417 0.00000000 0.10136667 0.10136667 8.111316e-07 8.111316e-07 FALSE TRUE
MSTRG.1974.3 ENSG00000266338 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF15 protein_coding   12.77451 9.984582 12.61395 0.5330668 0.1525604 0.3369454 0.6729897 0.1846426 0.9511059 0.1846426 0.4799625 2.30386792 0.05830417 0.01763333 0.07623333 0.05860000 5.653047e-01 8.111316e-07 FALSE TRUE
MSTRG.1974.5 ENSG00000266338 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF15 protein_coding   12.77451 9.984582 12.61395 0.5330668 0.1525604 0.3369454 1.2994558 1.8604575 0.6744997 0.5988477 0.3543923 -1.45026930 0.10859583 0.19286667 0.05400000 -0.13886667 4.510628e-01 8.111316e-07 FALSE TRUE
MSTRG.1974.8 ENSG00000266338 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF15 protein_coding   12.77451 9.984582 12.61395 0.5330668 0.1525604 0.3369454 0.6185602 0.3651955 0.3574555 0.2249018 0.3574555 -0.03007297 0.05167917 0.03906667 0.02770000 -0.01136667 6.518273e-01 8.111316e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000266338 E001 1.6061695 0.5221952136 2.906844e-01 4.314963e-01 1 144421390 144421515 126 - 0.199 0.560 2.181
ENSG00000266338 E002 1.0955117 0.2346760907 1.224125e-01 2.233888e-01 1 144421516 144421524 9 - 0.111 0.456 2.679
ENSG00000266338 E003 1.8276147 0.4255735101 1.711877e-01 2.897306e-01 1 144421525 144421566 42 - 0.199 0.606 2.388
ENSG00000266338 E004 11.8553309 0.0038273894 1.221481e-03 4.713337e-03 1 144421567 144421686 120 - 0.917 1.241 1.176
ENSG00000266338 E005 5.5218343 0.0031781746 1.132276e-03 4.412133e-03 1 144421687 144421692 6 - 0.558 0.989 1.742
ENSG00000266338 E006 9.4439064 0.0018045456 1.062620e-02 3.027586e-02 1 144421693 144421832 140 - 0.869 1.138 0.997
ENSG00000266338 E007 27.9931597 0.0028328048 1.597812e-01 2.748252e-01 1 144421833 144422142 310 - 1.410 1.505 0.328
ENSG00000266338 E008 8.2606196 0.0303764125 8.239473e-01 8.890769e-01 1 144422143 144422314 172 - 0.946 0.975 0.106
ENSG00000266338 E009 1.3974828 0.0569714918 2.246925e-03 7.989362e-03 1 144422315 144422397 83 - 0.000 0.555 13.031
ENSG00000266338 E010 103.3069904 0.0013371580 9.331027e-04 3.730107e-03 1 144422398 144422851 454 - 1.951 2.073 0.408
ENSG00000266338 E011 98.7706614 0.0005425853 1.461473e-04 7.305513e-04 1 144422852 144422939 88 - 1.923 2.057 0.450
ENSG00000266338 E012 173.2203888 0.0016579539 9.326164e-05 4.903593e-04 1 144422940 144423256 317 - 2.178 2.296 0.394
ENSG00000266338 E013 52.1263780 0.0004729658 4.200613e-02 9.473497e-02 1 144423870 144423929 60 - 1.674 1.771 0.327
ENSG00000266338 E014 18.9137575 0.0012451940 4.540116e-01 5.946936e-01 1 144423930 144423975 46 - 1.266 1.323 0.202
ENSG00000266338 E015 13.5226198 0.0012921891 7.888108e-01 8.648124e-01 1 144424690 144424862 173 - 1.148 1.172 0.084
ENSG00000266338 E016 5.2240784 0.0035945731 4.245613e-02 9.554520e-02 1 144425517 144425568 52 - 0.652 0.918 1.063
ENSG00000266338 E017 14.7028876 0.0230260594 3.642622e-01 5.086300e-01 1 144426278 144426370 93 - 1.149 1.247 0.348
ENSG00000266338 E018 3.9232181 0.0041992823 7.983694e-01 8.713168e-01 1 144426371 144426450 80 - 0.705 0.667 -0.158
ENSG00000266338 E019 0.1515154 0.0428295755 6.008074e-01   1 144427046 144427046 1 - 0.111 0.000 -10.907
ENSG00000266338 E020 6.3203643 0.0027421392 6.842704e-01 7.872735e-01 1 144427047 144427098 52 - 0.886 0.835 -0.196
ENSG00000266338 E021 12.7153993 0.0016074194 5.146190e-01 6.493536e-01 1 144427818 144427910 93 - 1.101 1.161 0.216
ENSG00000266338 E022 21.3665247 0.0038805171 1.706909e-01 2.890556e-01 1 144427911 144427990 80 - 1.299 1.405 0.368
ENSG00000266338 E023 10.5397274 0.0017254746 7.687366e-01 8.505416e-01 1 144428606 144428657 52 - 1.048 1.077 0.105
ENSG00000266338 E024 6.2313176 0.0027128835 9.277660e-01 9.585598e-01 1 144429700 144429810 111 - 0.869 0.857 -0.045
ENSG00000266338 E025 8.2407773 0.0315839690 4.339423e-01 5.763391e-01 1 144429811 144429863 53 - 1.012 0.901 -0.414
ENSG00000266338 E026 15.8869569 0.0238865919 7.598205e-01 8.440831e-01 1 144433773 144433824 52 - 1.244 1.205 -0.138
ENSG00000266338 E027 54.9503281 0.0058090397 9.064601e-01 9.445779e-01 1 144435111 144435316 206 - 1.745 1.752 0.023
ENSG00000266338 E028 34.6522177 0.0050803905 4.642599e-01 6.040040e-01 1 144435781 144435853 73 - 1.522 1.571 0.169
ENSG00000266338 E029 58.1961428 0.0004273456 1.512836e-01 2.634236e-01 1 144436895 144437109 215 - 1.801 1.734 -0.224
ENSG00000266338 E030 39.8342041 0.0012065124 5.039258e-01 6.398565e-01 1 144437945 144438047 103 - 1.632 1.594 -0.129
ENSG00000266338 E031 58.1813934 0.0004142649 2.450302e-01 3.800514e-01 1 144439829 144439992 164 - 1.797 1.743 -0.181
ENSG00000266338 E032 30.7386872 0.0006584818 2.686831e-01 4.071608e-01 1 144439993 144440038 46 - 1.533 1.463 -0.238
ENSG00000266338 E033 38.4685350 0.0008019811 9.627555e-02 1.847916e-01 1 144440141 144440208 68 - 1.638 1.543 -0.323
ENSG00000266338 E034 35.2342196 0.0006811674 7.746519e-02 1.553905e-01 1 144440209 144440295 87 - 1.604 1.500 -0.357
ENSG00000266338 E035 4.6766425 0.0502657595 4.031788e-01 5.469692e-01 1 144440402 144440581 180 - 0.815 0.668 -0.596
ENSG00000266338 E036 15.9725506 0.0012765757 9.188550e-03 2.675556e-02 1 144442670 144442920 251 - 1.317 1.090 -0.805
ENSG00000266338 E037 9.7152258 0.0017413060 1.211606e-05 7.896489e-05 1 144448245 144448450 206 - 1.199 0.700 -1.885
ENSG00000266338 E038 29.5924207 0.0006810545 5.050180e-05 2.843214e-04 1 144448775 144448916 142 - 1.595 1.331 -0.910
ENSG00000266338 E039 14.0786928 0.0037698872 4.330081e-04 1.901377e-03 1 144450772 144450802 31 - 1.311 0.973 -1.214
ENSG00000266338 E040 17.3873443 0.0428609173 3.941948e-02 8.995630e-02 1 144450803 144450870 68 - 1.378 1.111 -0.942
ENSG00000266338 E041 56.9244793 0.0087966547 1.195028e-03 4.623702e-03 1 144456537 144456805 269 - 1.854 1.646 -0.705
ENSG00000266338 E042 11.0689779 0.0122631785 2.349089e-02 5.875575e-02 1 144458847 144459036 190 - 1.191 0.937 -0.924
ENSG00000266338 E043 35.2857912 0.0195192815 1.538594e-01 2.669151e-01 1 144459366 144459483 118 - 1.620 1.496 -0.423
ENSG00000266338 E044 7.2529633 0.0225229289 2.560885e-01 3.930456e-01 1 144459484 144459488 5 - 0.988 0.834 -0.584
ENSG00000266338 E045 28.1074522 0.0106344120 1.667351e-01 2.839424e-01 1 144460843 144460961 119 - 1.514 1.406 -0.373
ENSG00000266338 E046 37.4551024 0.0005900801 4.571256e-04 1.995141e-03 1 144461381 144461676 296 - 1.671 1.469 -0.691