ENSG00000266074

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307745 ENSG00000266074 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHCC1 protein_coding protein_coding 7.91119 13.23223 4.380461 2.104275 0.1739138 -1.592702 0.7103133 1.1805495 0.0000000 0.68225574 0.00000000 -6.895483791 0.09330417 0.08660000 0.00000000 -0.086600000 0.27551758 0.01928487 FALSE TRUE
ENST00000578541 ENSG00000266074 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHCC1 protein_coding retained_intron 7.91119 13.23223 4.380461 2.104275 0.1739138 -1.592702 0.4800792 1.0738609 0.0000000 0.63980321 0.00000000 -6.760035779 0.04581250 0.06936667 0.00000000 -0.069366667 0.29246395 0.01928487 FALSE FALSE
ENST00000582709 ENSG00000266074 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHCC1 protein_coding retained_intron 7.91119 13.23223 4.380461 2.104275 0.1739138 -1.592702 2.8777279 5.7690700 0.8003105 1.00214580 0.29031421 -2.834290571 0.32558750 0.44403333 0.17916667 -0.264866667 0.04565873 0.01928487 FALSE TRUE
ENST00000583828 ENSG00000266074 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHCC1 protein_coding processed_transcript 7.91119 13.23223 4.380461 2.104275 0.1739138 -1.592702 0.7725376 1.9889730 0.6738664 0.32560400 0.09038177 -1.547472562 0.09286250 0.15426667 0.15300000 -0.001266667 1.00000000 0.01928487   FALSE
ENST00000584330 ENSG00000266074 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHCC1 protein_coding retained_intron 7.91119 13.23223 4.380461 2.104275 0.1739138 -1.592702 0.4982366 0.3682525 0.1464351 0.36825247 0.09103483 -1.273785146 0.06351250 0.02163333 0.03296667 0.011333333 0.63418012 0.01928487 FALSE FALSE
ENST00000675386 ENSG00000266074 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHCC1 protein_coding protein_coding 7.91119 13.23223 4.380461 2.104275 0.1739138 -1.592702 0.6933721 0.2702188 1.0400145 0.17717118 0.20597203 1.905783622 0.11360417 0.02263333 0.23563333 0.213000000 0.01928487 0.01928487 FALSE TRUE
MSTRG.15274.2 ENSG00000266074 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHCC1 protein_coding   7.91119 13.23223 4.380461 2.104275 0.1739138 -1.592702 0.1964816 0.0740594 0.3634038 0.07405940 0.04129299 2.151255676 0.03701667 0.00760000 0.08363333 0.076033333 0.02694897 0.01928487 FALSE TRUE
MSTRG.15274.5 ENSG00000266074 HEK293_OSMI2_2hA HEK293_TMG_2hB BAHCC1 protein_coding   7.91119 13.23223 4.380461 2.104275 0.1739138 -1.592702 0.6907558 1.0177705 1.0190290 0.09694516 0.25359763 0.001765491 0.10482917 0.07930000 0.23790000 0.158600000 0.04014180 0.01928487 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000266074 E001 1.3598223 0.0103118879 4.176594e-02 9.430116e-02 17 81395457 81395471 15 + 0.557 0.238 -1.838
ENSG00000266074 E002 1.6532882 0.0578359682 5.954514e-02 1.258411e-01 17 81395472 81395474 3 + 0.607 0.293 -1.655
ENSG00000266074 E003 5.8685728 0.0323131953 3.880707e-02 8.882947e-02 17 81395475 81395635 161 + 0.966 0.712 -0.991
ENSG00000266074 E004 9.4783820 0.0259107819 1.281043e-04 6.505380e-04 17 81399534 81399739 206 + 1.232 0.805 -1.578
ENSG00000266074 E005 2.1974458 0.0266394149 5.548847e-03 1.741514e-02 17 81399740 81399773 34 + 0.728 0.296 -2.156
ENSG00000266074 E006 17.3204554 0.0010585002 7.981736e-04 3.252911e-03 17 81399774 81399917 144 + 1.365 1.143 -0.780
ENSG00000266074 E007 2.1033751 0.1265219316 2.498709e-01 3.857498e-01 17 81401090 81401411 322 + 0.272 0.557 1.584
ENSG00000266074 E008 67.4501551 0.0159670801 1.167728e-03 4.531299e-03 17 81401412 81402979 1568 + 1.564 1.882 1.076
ENSG00000266074 E009 3.9387470 0.0040601864 3.515842e-03 1.177211e-02 17 81426800 81426803 4 + 0.876 0.504 -1.572
ENSG00000266074 E010 17.4259584 0.0013585137 3.602358e-03 1.201738e-02 17 81426804 81426979 176 + 1.340 1.151 -0.664
ENSG00000266074 E011 18.0437261 0.0271257800 2.204557e-02 5.577472e-02 17 81438370 81438492 123 + 1.366 1.172 -0.682
ENSG00000266074 E012 23.4537055 0.0008117080 3.713451e-07 3.370716e-06 17 81441831 81441956 126 + 1.538 1.232 -1.059
ENSG00000266074 E013 87.8938019 0.0021915898 9.432500e-12 1.974758e-10 17 81441957 81443212 1256 + 2.054 1.823 -0.777
ENSG00000266074 E014 31.6674731 0.0765059851 1.163017e-01 2.146855e-01 17 81443213 81443464 252 + 1.565 1.435 -0.446
ENSG00000266074 E015 17.9672678 0.0855435614 2.277125e-01 3.596753e-01 17 81443465 81443564 100 + 1.313 1.205 -0.378
ENSG00000266074 E016 16.4782524 0.0479396253 4.832227e-01 6.212620e-01 17 81443809 81443917 109 + 1.210 1.197 -0.046
ENSG00000266074 E017 0.4502799 0.0316616488 2.012738e-02 5.175109e-02 17 81443918 81444273 356 + 0.363 0.000 -22.691
ENSG00000266074 E018 11.9881935 0.0378756680 4.345242e-01 5.768818e-01 17 81444381 81444568 188 + 1.090 1.062 -0.102
ENSG00000266074 E019 16.1136955 0.0131272715 9.905017e-01 9.982051e-01 17 81444668 81444826 159 + 1.147 1.206 0.209
ENSG00000266074 E020 19.0749448 0.0074873209 3.506007e-01 4.947873e-01 17 81445015 81445178 164 + 1.275 1.248 -0.093
ENSG00000266074 E021 25.0815722 0.0008094189 5.483698e-02 1.177180e-01 17 81445354 81445681 328 + 1.433 1.351 -0.283
ENSG00000266074 E022 3.0634564 0.0051895249 6.002762e-01 7.215357e-01 17 81446738 81446830 93 + 0.607 0.566 -0.184
ENSG00000266074 E023 92.0157989 0.0080120029 1.823129e-02 4.763740e-02 17 81447036 81447848 813 + 1.978 1.912 -0.220
ENSG00000266074 E024 38.8715899 0.0005577322 1.511674e-03 5.673945e-03 17 81451668 81451870 203 + 1.644 1.518 -0.432
ENSG00000266074 E025 27.8237790 0.0122921289 4.309731e-02 9.673305e-02 17 81451971 81452107 137 + 1.492 1.384 -0.373
ENSG00000266074 E026 36.9288013 0.0018686483 1.937504e-02 5.014746e-02 17 81452723 81452851 129 + 1.599 1.512 -0.298
ENSG00000266074 E027 39.5752895 0.0072298233 3.465012e-02 8.098451e-02 17 81455267 81455390 124 + 1.627 1.543 -0.286
ENSG00000266074 E028 0.6664265 0.0178138268 4.862582e-01 6.240527e-01 17 81456158 81456296 139 + 0.272 0.172 -0.836
ENSG00000266074 E029 53.1919182 0.0004761787 4.519938e-01 5.928910e-01 17 81456297 81456585 289 + 1.681 1.699 0.061
ENSG00000266074 E030 47.4199563 0.0006862411 9.128502e-01 9.487839e-01 17 81457410 81457592 183 + 1.604 1.666 0.212
ENSG00000266074 E031 61.9775142 0.0007340331 6.190322e-01 7.365367e-01 17 81458165 81458466 302 + 1.700 1.782 0.277
ENSG00000266074 E032 39.1929247 0.0178250405 9.365962e-01 9.641181e-01 17 81458621 81458725 105 + 1.521 1.587 0.227
ENSG00000266074 E033 44.9537787 0.0065870030 5.717478e-01 6.979837e-01 17 81458813 81458969 157 + 1.613 1.635 0.075
ENSG00000266074 E034 35.0176335 0.0005866519 5.008511e-01 6.370626e-01 17 81459054 81459168 115 + 1.447 1.546 0.340
ENSG00000266074 E035 33.3474459 0.0031190465 7.121545e-01 8.089819e-01 17 81459253 81459328 76 + 1.433 1.516 0.287
ENSG00000266074 E036 0.1482932 0.0438534908 1.000000e+00   17 81459391 81459495 105 + 0.000 0.094 19.110
ENSG00000266074 E037 42.0857488 0.0019887824 6.345286e-01 7.489594e-01 17 81459496 81459604 109 + 1.569 1.599 0.100
ENSG00000266074 E038 47.1427227 0.0066230391 3.520470e-01 4.962867e-01 17 81460277 81460396 120 + 1.644 1.643 -0.004
ENSG00000266074 E039 51.7711912 0.0017941901 5.200073e-01 6.540394e-01 17 81460530 81460706 177 + 1.617 1.710 0.316
ENSG00000266074 E040 11.9472133 0.0015345084 6.060614e-02 1.276533e-01 17 81460866 81460889 24 + 0.876 1.136 0.959
ENSG00000266074 E041 165.6427493 0.0027943840 6.627741e-02 1.371812e-01 17 81460890 81462046 1157 + 2.088 2.221 0.446
ENSG00000266074 E042 0.5911862 0.0183080725 5.800401e-03 1.808790e-02 17 81462559 81462739 181 + 0.438 0.000 -23.146
ENSG00000266074 E043 80.2806683 0.0003442240 9.796013e-01 9.912908e-01 17 81462740 81462976 237 + 1.830 1.886 0.189
ENSG00000266074 E044 567.0464402 0.0177775805 9.567869e-05 5.017311e-04 17 81463611 81466373 2763 + 2.526 2.790 0.880