ENSG00000266028

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000419187 ENSG00000266028 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2 protein_coding protein_coding 16.60255 20.13382 11.61561 0.6352323 0.3123066 -0.7930311 0.4215408 0.1560064 0.7509847 0.1560064 0.20479876 2.1966289 0.03027083 0.0080000 0.06383333 0.05583333 7.355514e-02 2.173025e-10 FALSE TRUE
ENST00000573034 ENSG00000266028 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2 protein_coding protein_coding 16.60255 20.13382 11.61561 0.6352323 0.3123066 -0.7930311 5.0877103 3.8452873 6.0637276 1.4079127 0.60997622 0.6557438 0.33365000 0.1872000 0.52440000 0.33720000 1.038187e-02 2.173025e-10 FALSE TRUE
ENST00000604010 ENSG00000266028 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2 protein_coding protein_coding 16.60255 20.13382 11.61561 0.6352323 0.3123066 -0.7930311 2.8552360 7.0231750 0.2424528 1.3109664 0.01586671 -4.8000905 0.14157917 0.3533333 0.02083333 -0.33250000 2.173025e-10 2.173025e-10 FALSE TRUE
ENST00000605476 ENSG00000266028 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2 protein_coding protein_coding 16.60255 20.13382 11.61561 0.6352323 0.3123066 -0.7930311 2.0876176 2.6912964 1.1132473 0.2111419 0.20127112 -1.2659763 0.12037500 0.1333000 0.09513333 -0.03816667 3.287186e-01 2.173025e-10 FALSE TRUE
ENST00000624873 ENSG00000266028 HEK293_OSMI2_2hA HEK293_TMG_2hB SRGAP2 protein_coding protein_coding 16.60255 20.13382 11.61561 0.6352323 0.3123066 -0.7930311 3.9762789 4.5102471 1.7985134 0.4801212 0.54105481 -1.3215974 0.23930833 0.2230667 0.15356667 -0.06950000 5.395265e-01 2.173025e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000266028 E001 0.1451727 0.0431448699 3.087700e-01   1 206203346 206203482 137 + 0.138 0.000 -19.562
ENSG00000266028 E002 3.5593550 0.0048971346 1.252137e-01 2.274383e-01 1 206203541 206203650 110 + 0.740 0.583 -0.671
ENSG00000266028 E003 0.0000000       1 206203888 206203907 20 +      
ENSG00000266028 E004 0.0000000       1 206203908 206204000 93 +      
ENSG00000266028 E005 1.2470141 0.0104663631 5.981528e-01 7.198101e-01 1 206204001 206205428 1428 + 0.243 0.383 0.915
ENSG00000266028 E006 6.6498824 0.0029723815 2.229586e-02 5.628842e-02 1 206205429 206205625 197 + 0.983 0.784 -0.761
ENSG00000266028 E007 3.0767092 0.0639941314 2.677227e-01 4.060627e-01 1 206205626 206205672 47 + 0.676 0.550 -0.556
ENSG00000266028 E008 14.5584122 0.0177999390 1.263199e-04 6.426997e-04 1 206205673 206205894 222 + 1.349 1.027 -1.148
ENSG00000266028 E009 4.3804185 0.0139891129 3.555698e-02 8.272335e-02 1 206205895 206205908 14 + 0.845 0.614 -0.947
ENSG00000266028 E010 5.1469783 0.0035095848 4.123966e-02 9.332199e-02 1 206205909 206205964 56 + 0.889 0.695 -0.771
ENSG00000266028 E011 9.3874942 0.0096158202 5.441189e-02 1.169748e-01 1 206205965 206206037 73 + 1.088 0.950 -0.509
ENSG00000266028 E012 0.2934659 0.0295073801 7.231180e-01   1 206206038 206208229 2192 + 0.138 0.108 -0.411
ENSG00000266028 E013 0.0000000       1 206214505 206214611 107 +      
ENSG00000266028 E014 0.0000000       1 206214723 206214840 118 +      
ENSG00000266028 E015 0.0000000       1 206296820 206296869 50 +      
ENSG00000266028 E016 31.3496796 0.0006697582 6.838619e-09 8.695589e-08 1 206303281 206303473 193 + 1.645 1.373 -0.932
ENSG00000266028 E017 0.0000000       1 206312148 206312247 100 +      
ENSG00000266028 E018 17.5621699 0.0010790731 1.270348e-05 8.241257e-05 1 206342846 206342849 4 + 1.398 1.128 -0.948
ENSG00000266028 E019 17.9017194 0.0012467743 1.330505e-05 8.588961e-05 1 206342850 206342900 51 + 1.404 1.137 -0.938
ENSG00000266028 E020 21.1156462 0.0027661717 1.907584e-05 1.188965e-04 1 206342901 206343008 108 + 1.464 1.219 -0.854
ENSG00000266028 E021 26.3770631 0.0045464310 3.081176e-04 1.412612e-03 1 206384014 206384076 63 + 1.522 1.342 -0.620
ENSG00000266028 E022 55.6820993 0.0066177400 5.861339e-08 6.224135e-07 1 206392689 206392904 216 + 1.870 1.631 -0.808
ENSG00000266028 E023 37.3438921 0.0069911019 8.612546e-06 5.808961e-05 1 206393545 206393673 129 + 1.690 1.472 -0.744
ENSG00000266028 E024 5.2875353 0.0253063035 3.591280e-03 1.198530e-02 1 206401421 206401423 3 + 0.966 0.614 -1.406
ENSG00000266028 E025 14.7509597 0.0320641069 3.988769e-02 9.082347e-02 1 206401424 206401645 222 + 1.270 1.115 -0.551
ENSG00000266028 E026 0.0000000       1 206404963 206405248 286 +      
ENSG00000266028 E027 6.0702227 0.0027668498 2.000913e-01 3.263654e-01 1 206405249 206405350 102 + 0.889 0.804 -0.330
ENSG00000266028 E028 50.5841029 0.0103357289 6.379546e-03 1.960908e-02 1 206406377 206406574 198 + 1.757 1.657 -0.340
ENSG00000266028 E029 2.1338457 0.0132677663 2.705958e-03 9.390996e-03 1 206406575 206408031 1457 + 0.709 0.266 -2.283
ENSG00000266028 E030 73.0917449 0.0066582403 6.883646e-04 2.856455e-03 1 206415889 206415973 85 + 1.917 1.815 -0.345
ENSG00000266028 E031 55.6797659 0.0080292734 5.557379e-02 1.189597e-01 1 206419373 206419400 28 + 1.760 1.726 -0.115
ENSG00000266028 E032 45.8017198 0.0005643419 6.461871e-03 1.982481e-02 1 206421250 206421274 25 + 1.693 1.637 -0.191
ENSG00000266028 E033 64.5764160 0.0030810356 5.324403e-03 1.681630e-02 1 206430162 206430222 61 + 1.838 1.785 -0.180
ENSG00000266028 E034 65.0437242 0.0086353258 1.621645e-01 2.779272e-01 1 206436965 206437042 78 + 1.808 1.809 0.001
ENSG00000266028 E035 0.3289534 0.0289947303 7.227806e-01   1 206437619 206437963 345 + 0.138 0.108 -0.408
ENSG00000266028 E036 93.0931099 0.0018194909 9.120116e-02 1.770084e-01 1 206437964 206438098 135 + 1.948 1.965 0.056
ENSG00000266028 E037 81.5994488 0.0003679038 1.700665e-01 2.882786e-01 1 206439976 206440060 85 + 1.883 1.914 0.106
ENSG00000266028 E038 57.7562489 0.0016289741 1.478526e-01 2.587623e-01 1 206440061 206440081 21 + 1.746 1.760 0.047
ENSG00000266028 E039 138.4993317 0.0007025138 5.548525e-01 6.837779e-01 1 206446075 206446299 225 + 2.089 2.157 0.227
ENSG00000266028 E040 90.3871717 0.0003794468 3.484091e-01 4.926412e-01 1 206450386 206450465 80 + 1.916 1.966 0.170
ENSG00000266028 E041 0.8104664 0.0148893076 9.295025e-01 9.596083e-01 1 206453199 206453199 1 + 0.243 0.266 0.176
ENSG00000266028 E042 118.2455149 0.0030942917 3.141236e-01 4.568082e-01 1 206453200 206453380 181 + 2.033 2.077 0.149
ENSG00000266028 E043 3.6535112 0.0044670216 1.780495e-01 2.986967e-01 1 206453661 206454143 483 + 0.740 0.613 -0.535
ENSG00000266028 E044 24.5579171 0.0009281621 5.363374e-02 1.156076e-01 1 206454144 206454877 734 + 1.234 1.462 0.796
ENSG00000266028 E045 99.5000548 0.0003366398 3.914339e-01 5.353449e-01 1 206454878 206455024 147 + 1.952 2.007 0.185
ENSG00000266028 E046 58.7952401 0.0004373889 3.174508e-05 1.877677e-04 1 206455025 206455772 748 + 1.564 1.858 0.999
ENSG00000266028 E047 40.3750501 0.0005565259 4.444474e-05 2.535510e-04 1 206455773 206456159 387 + 1.371 1.705 1.144
ENSG00000266028 E048 6.3476100 0.0444975772 2.042146e-03 7.356921e-03 1 206458371 206458409 39 + 1.046 0.647 -1.558
ENSG00000266028 E049 118.9894762 0.0018762298 1.667657e-04 8.212441e-04 1 206458623 206458947 325 + 2.099 2.044 -0.181
ENSG00000266028 E050 1247.5144146 0.0085492197 2.578261e-08 2.941901e-07 1 206461037 206464436 3400 + 2.919 3.163 0.810