ENSG00000265808

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000578049 ENSG00000265808 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22B protein_coding protein_coding 42.47224 36.69855 56.02871 6.494093 2.510756 0.6103078 4.133333 3.092655 5.881637 0.5249780 0.1735411 0.925165246 0.09653333 0.08593333 0.1052667 0.01933333 4.276517e-01 3.596648e-06 FALSE TRUE
MSTRG.1926.2 ENSG00000265808 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22B protein_coding   42.47224 36.69855 56.02871 6.494093 2.510756 0.6103078 18.857688 21.066675 21.196440 3.8823107 0.3259248 0.008855108 0.45970417 0.57526667 0.3792667 -0.19600000 5.051420e-06 3.596648e-06   FALSE
MSTRG.1926.3 ENSG00000265808 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22B protein_coding   42.47224 36.69855 56.02871 6.494093 2.510756 0.6103078 7.740256 2.851624 11.377334 0.9392545 1.5331126 1.992524197 0.17133333 0.07260000 0.2023000 0.12970000 3.730226e-03 3.596648e-06 FALSE TRUE
MSTRG.1926.9 ENSG00000265808 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22B protein_coding   42.47224 36.69855 56.02871 6.494093 2.510756 0.6103078 9.878834 8.148687 14.240056 1.1171151 1.2713719 0.804558666 0.23180833 0.22590000 0.2533333 0.02743333 5.731523e-01 3.596648e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000265808 E001 290.2519736 0.0027942292 1.253384e-02 3.481312e-02 1 120150898 120156110 5213 - 2.505 2.421 -0.280
ENSG00000265808 E002 276.1446921 0.0005499007 8.766741e-08 8.997902e-07 1 120156111 120156753 643 - 2.392 2.510 0.394
ENSG00000265808 E003 490.5848035 0.0005248972 1.968443e-04 9.502972e-04 1 120156754 120157192 439 - 2.670 2.730 0.199
ENSG00000265808 E004 1.1092308 0.0290629921 9.802209e-01 9.916424e-01 1 120157291 120157320 30 - 0.326 0.330 0.025
ENSG00000265808 E005 2.2110868 0.0083137827 5.759459e-01 7.014633e-01 1 120157321 120157388 68 - 0.471 0.563 0.440
ENSG00000265808 E006 3.0486216 0.1080701499 5.476830e-01 6.776857e-01 1 120157389 120157443 55 - 0.546 0.678 0.583
ENSG00000265808 E007 12.0188700 0.0014753347 5.232325e-03 1.656415e-02 1 120157444 120159199 1756 - 1.228 0.952 -0.999
ENSG00000265808 E008 0.7468662 0.0303102777 9.011591e-01 9.409586e-01 1 120159200 120159215 16 - 0.264 0.244 -0.149
ENSG00000265808 E009 1.8863747 0.0075835558 5.257187e-01 6.590556e-01 1 120159216 120159267 52 - 0.510 0.401 -0.559
ENSG00000265808 E010 6.4633389 0.0025597092 1.300723e-02 3.592782e-02 1 120159268 120159402 135 - 0.997 0.680 -1.237
ENSG00000265808 E011 0.7490443 0.1113008590 5.522334e-02 1.183760e-01 1 120159403 120159422 20 - 0.380 0.000 -12.098
ENSG00000265808 E012 350.7247531 0.0011058803 8.491200e-01 9.063586e-01 1 120160384 120160530 147 - 2.552 2.552 -0.002
ENSG00000265808 E013 341.6948119 0.0001477264 7.494847e-02 1.514535e-01 1 120163210 120163370 161 - 2.557 2.524 -0.111
ENSG00000265808 E014 246.6046937 0.0001934157 1.058383e-01 1.993573e-01 1 120168840 120168949 110 - 2.418 2.381 -0.120
ENSG00000265808 E015 2.5206402 0.0057487072 3.441712e-05 2.016334e-04 1 120169982 120170119 138 - 0.759 0.000 -13.861
ENSG00000265808 E016 0.2944980 0.4021062617 4.290502e-01   1 120170865 120170922 58 - 0.193 0.000 -10.773
ENSG00000265808 E017 1.7307051 0.1007954461 6.150354e-01 7.333843e-01 1 120172667 120172726 60 - 0.380 0.466 0.464
ENSG00000265808 E018 224.0110511 0.0008046075 6.485881e-03 1.988591e-02 1 120176307 120176588 282 - 2.390 2.315 -0.249