ENSG00000264522

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000581312 ENSG00000264522 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD7B protein_coding protein_coding 10.05657 8.467019 10.69022 0.8126137 0.3332833 0.3360115 3.698466 4.4859853 2.737005 0.5706745 0.05457214 -0.7107780 0.3842375 0.5333000 0.2568333 -0.27646667 0.003377623 0.003377623 FALSE TRUE
MSTRG.2151.2 ENSG00000264522 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD7B protein_coding   10.05657 8.467019 10.69022 0.8126137 0.3332833 0.3360115 4.592821 3.4735761 5.255982 0.5399118 0.31241512 0.5961334 0.4494125 0.4109667 0.4908000 0.07983333 0.529526919 0.003377623 FALSE TRUE
MSTRG.2151.4 ENSG00000264522 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD7B protein_coding   10.05657 8.467019 10.69022 0.8126137 0.3332833 0.3360115 1.507778 0.3274131 2.503330 0.2826442 0.05122464 2.8970118 0.1405000 0.0334000 0.2343333 0.20093333 0.025041871 0.003377623 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000264522 E001 492.7901333 0.0134778359 7.688882e-07 6.546971e-06 1 149937812 149942604 4793 - 2.504 2.800 0.983
ENSG00000264522 E002 519.6081326 0.0005402967 2.423877e-01 3.769868e-01 1 149942605 149944693 2089 - 2.670 2.750 0.267
ENSG00000264522 E003 45.4197536 0.0084933624 3.028898e-01 4.448217e-01 1 149944694 149944786 93 - 1.674 1.665 -0.030
ENSG00000264522 E004 97.6835345 0.0003172718 1.051672e-02 3.001627e-02 1 149944787 149945065 279 - 2.009 1.982 -0.090
ENSG00000264522 E005 1.1373304 0.0110659678 8.850125e-01 9.304942e-01 1 149947224 149947250 27 - 0.299 0.358 0.373
ENSG00000264522 E006 43.3868765 0.0005970913 3.171247e-01 4.599685e-01 1 149947251 149947290 40 - 1.643 1.652 0.033
ENSG00000264522 E007 36.4534190 0.0077345912 4.145490e-01 5.579562e-01 1 149947291 149947335 45 - 1.568 1.568 0.000
ENSG00000264522 E008 61.4650975 0.0004229937 8.181698e-02 1.624157e-01 1 149948969 149949083 115 - 1.802 1.787 -0.050
ENSG00000264522 E009 67.7906363 0.0033736507 4.014068e-02 9.129746e-02 1 149949629 149949778 150 - 1.857 1.816 -0.139
ENSG00000264522 E010 69.0080413 0.0039719314 9.011140e-02 1.753011e-01 1 149950094 149950221 128 - 1.857 1.834 -0.079
ENSG00000264522 E011 64.2602867 0.0004321604 7.073626e-05 3.836685e-04 1 149959684 149959796 113 - 1.873 1.764 -0.368
ENSG00000264522 E012 3.7287501 0.0044095813 3.859525e-01 5.301641e-01 1 149960927 149964221 3295 - 0.561 0.740 0.765
ENSG00000264522 E013 66.4440931 0.0004422164 1.324100e-06 1.071262e-05 1 149964222 149964349 128 - 1.903 1.759 -0.484
ENSG00000264522 E014 46.4181964 0.0057581566 2.480737e-02 6.147873e-02 1 149965777 149965878 102 - 1.717 1.637 -0.273
ENSG00000264522 E015 42.8620906 0.0017989902 4.754420e-02 1.048081e-01 1 149967294 149967387 94 - 1.668 1.620 -0.163
ENSG00000264522 E016 47.2369307 0.0005522202 2.200004e-02 5.567662e-02 1 149967388 149967521 134 - 1.712 1.659 -0.181
ENSG00000264522 E017 55.5125745 0.0078409928 1.354404e-01 2.417241e-01 1 149971063 149971251 189 - 1.767 1.733 -0.114
ENSG00000264522 E018 0.5985731 0.0245056486 2.395127e-01 3.735456e-01 1 149971252 149971261 10 - 0.299 0.121 -1.629
ENSG00000264522 E019 38.5174018 0.0181141062 5.584562e-02 1.194227e-01 1 149977426 149977535 110 - 1.646 1.540 -0.361
ENSG00000264522 E020 20.9202392 0.0097992882 1.595245e-02 4.262424e-02 1 149977536 149977570 35 - 1.411 1.257 -0.536
ENSG00000264522 E021 15.3340543 0.0118353252 6.918905e-02 1.420253e-01 1 149977571 149977576 6 - 1.267 1.143 -0.439
ENSG00000264522 E022 39.0978326 0.0122168616 2.739284e-03 9.490656e-03 1 150010448 150010593 146 - 1.683 1.514 -0.577
ENSG00000264522 E023 29.0861078 0.0095670576 5.647767e-04 2.402066e-03 1 150010594 150010685 92 - 1.579 1.371 -0.718
ENSG00000264522 E024 17.7435425 0.0481990660 3.187377e-03 1.081819e-02 1 150010686 150010727 42 - 1.416 1.101 -1.110