ENSG00000263956

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000614015 ENSG00000263956 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF11 protein_coding protein_coding 5.467598 3.405322 5.30998 0.1958777 0.2619106 0.6393994 1.1164647 1.45897722 0.2500726 0.68838681 0.25007258 -2.4978258 0.21489167 0.4092000 0.04386667 -0.3653333333 7.009414e-02 2.049064e-05 FALSE TRUE
ENST00000614506 ENSG00000263956 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF11 protein_coding nonsense_mediated_decay 5.467598 3.405322 5.30998 0.1958777 0.2619106 0.6393994 0.6171439 0.34605309 0.5375652 0.06269898 0.16137781 0.6209385 0.11516250 0.1003333 0.10116667 0.0008333333 1.000000e+00 2.049064e-05 TRUE TRUE
ENST00000615281 ENSG00000263956 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF11 protein_coding protein_coding 5.467598 3.405322 5.30998 0.1958777 0.2619106 0.6393994 0.2820540 0.00000000 0.6071617 0.00000000 0.33262882 5.9475766 0.05387917 0.0000000 0.12093333 0.1209333333 2.601475e-01 2.049064e-05 FALSE TRUE
MSTRG.2066.2 ENSG00000263956 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF11 protein_coding   5.467598 3.405322 5.30998 0.1958777 0.2619106 0.6393994 0.4487932 0.22590763 0.1701123 0.19277201 0.08690089 -0.3893253 0.07465417 0.0683000 0.03360000 -0.0347000000 1.000000e+00 2.049064e-05 FALSE TRUE
MSTRG.2066.7 ENSG00000263956 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF11 protein_coding   5.467598 3.405322 5.30998 0.1958777 0.2619106 0.6393994 2.0147077 1.02907955 2.1277687 0.52138375 0.24241105 1.0407997 0.36459167 0.3209667 0.39876667 0.0778000000 8.500693e-01 2.049064e-05 FALSE TRUE
MSTRG.2066.9 ENSG00000263956 HEK293_OSMI2_2hA HEK293_TMG_2hB NBPF11 protein_coding   5.467598 3.405322 5.30998 0.1958777 0.2619106 0.6393994 0.3974240 0.04012409 1.0121914 0.04012409 0.14993293 4.3500174 0.06917917 0.0127000 0.18960000 0.1769000000 2.049064e-05 2.049064e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000263956 E001 1.9949270 0.0074131000 7.058240e-01 0.8041098891 1 148101160 148101323 164 - 0.509 0.462 -0.229
ENSG00000263956 E002 1.7693120 0.0082652349 1.995467e-02 0.0513900039 1 148102047 148102150 104 - 0.192 0.607 2.451
ENSG00000263956 E003 5.2587332 0.0034064486 3.985953e-03 0.0131034699 1 148102151 148102212 62 - 0.545 0.954 1.674
ENSG00000263956 E004 63.2763743 0.0206441141 1.974304e-05 0.0001226113 1 148102213 148102798 586 - 1.608 1.961 1.193
ENSG00000263956 E005 9.1203286 0.0142724755 1.920224e-01 0.3162925540 1 148102799 148103042 244 - 0.916 1.093 0.653
ENSG00000263956 E006 12.4625392 0.0155025513 4.054861e-01 0.5491716434 1 148103043 148103330 288 - 1.063 1.180 0.419
ENSG00000263956 E007 20.8463734 0.0346550446 5.755683e-01 0.7011477441 1 148103331 148103515 185 - 1.293 1.376 0.286
ENSG00000263956 E008 6.5202791 0.0613267011 4.518451e-01 0.5927654022 1 148103516 148103529 14 - 0.930 0.822 -0.414
ENSG00000263956 E009 10.5876351 0.0021598000 9.678283e-01 0.9838970279 1 148103530 148103565 36 - 1.053 1.080 0.098
ENSG00000263956 E010 58.3110555 0.0006199759 2.557095e-01 0.3926264204 1 148103566 148103912 347 - 1.727 1.803 0.255
ENSG00000263956 E011 17.6663501 0.0010378387 4.067256e-01 0.5503445974 1 148104537 148104582 46 - 1.220 1.310 0.316
ENSG00000263956 E012 16.7474001 0.0012031437 1.104234e-01 0.2061571142 1 148104583 148104645 63 - 1.287 1.179 -0.384
ENSG00000263956 E013 26.3640151 0.0007952562 9.592348e-01 0.9784499656 1 148105360 148105528 169 - 1.421 1.442 0.072
ENSG00000263956 E014 11.9533833 0.0247208317 3.229930e-01 0.4663396199 1 148106181 148106232 52 - 1.043 1.178 0.485
ENSG00000263956 E015 11.0907058 0.0415678718 7.122785e-01 0.8090645866 1 148106942 148107114 173 - 1.043 1.111 0.246
ENSG00000263956 E016 7.9059854 0.0022175453 5.699568e-01 0.6964704921 1 148107711 148107762 52 - 0.958 0.916 -0.159
ENSG00000263956 E017 16.6539559 0.0015358285 2.422584e-01 0.3768505290 1 148108482 148108654 173 - 1.182 1.302 0.422
ENSG00000263956 E018 9.3057361 0.0868925793 9.688230e-01 0.9844889152 1 148109284 148109335 52 - 0.996 1.035 0.145
ENSG00000263956 E019 1.2103832 0.0127560445 7.263517e-01 0.8194147800 1 148109336 148109411 76 - 0.379 0.330 -0.288
ENSG00000263956 E020 10.1388446 0.0018364278 3.731187e-01 0.5175520138 1 148110378 148110457 80 - 1.074 1.006 -0.250
ENSG00000263956 E021 11.8478805 0.0017792323 3.612539e-01 0.5056561923 1 148110458 148110541 84 - 1.131 1.067 -0.233
ENSG00000263956 E022 9.3454030 0.0102551887 4.727973e-01 0.6118360423 1 148114437 148114488 52 - 1.031 0.973 -0.215
ENSG00000263956 E023 17.7888120 0.0010701261 7.558693e-01 0.8410895494 1 148115793 148115998 206 - 1.268 1.267 -0.003
ENSG00000263956 E024 5.9198506 0.0028158660 5.509555e-02 0.1181643271 1 148116463 148116535 73 - 0.690 0.954 1.036
ENSG00000263956 E025 10.4720342 0.0017434304 7.079898e-01 0.8057293234 1 148117572 148117786 215 - 1.020 1.081 0.222
ENSG00000263956 E026 13.4785450 0.0015442736 1.751151e-02 0.0460655664 1 148118620 148118722 103 - 1.234 1.037 -0.706
ENSG00000263956 E027 21.9902158 0.0098254074 7.344467e-03 0.0221139441 1 148120501 148120710 210 - 1.439 1.233 -0.718
ENSG00000263956 E028 13.8323888 0.0014678290 6.106471e-02 0.1284264412 1 148122055 148122266 212 - 1.227 1.081 -0.524
ENSG00000263956 E029 6.3797151 0.0037845378 1.227498e-01 0.2238827179 1 148122729 148122801 73 - 0.944 0.774 -0.657
ENSG00000263956 E030 8.7371074 0.0173339671 1.856079e-01 0.3082541593 1 148123853 148124067 215 - 1.053 0.914 -0.516
ENSG00000263956 E031 2.4702877 0.0060186797 3.699796e-02 0.0854712178 1 148124899 148125001 103 - 0.665 0.331 -1.665
ENSG00000263956 E032 6.6271730 0.0152376420 5.000246e-02 0.1091816333 1 148126829 148127038 210 - 0.983 0.745 -0.921
ENSG00000263956 E033 1.2157810 0.0117076798 9.664862e-01 0.9829757362 1 148127141 148127288 148 - 0.325 0.331 0.038
ENSG00000263956 E034 1.1738620 0.0113125452 1.422932e-01 0.2511648260 1 148135124 148135247 124 - 0.192 0.463 1.772
ENSG00000263956 E035 8.6201069 0.0019845047 3.845363e-01 0.5286818295 1 148135672 148135813 142 - 1.008 0.935 -0.271
ENSG00000263956 E036 2.1544813 0.3754796161 9.966048e-01 1.0000000000 1 148135814 148135885 72 - 0.468 0.524 0.274
ENSG00000263956 E037 8.0695825 0.0034396451 9.768871e-02 0.1869698105 1 148135886 148136037 152 - 1.020 0.851 -0.635
ENSG00000263956 E038 6.0845004 0.0371620866 4.782299e-02 0.1053099609 1 148137711 148137809 99 - 0.958 0.681 -1.091
ENSG00000263956 E039 0.5085815 0.2633025448 5.021945e-01 0.6382614398 1 148138898 148138947 50 - 0.107 0.247 1.460
ENSG00000263956 E040 1.9207058 0.1099059263 6.975828e-02 0.1429691522 1 148140512 148140564 53 - 0.609 0.243 -2.026
ENSG00000263956 E041 11.3905213 0.0034762990 5.353403e-04 0.0022919460 1 148143415 148143686 272 - 1.213 0.874 -1.242
ENSG00000263956 E042 2.1005322 0.0530713975 8.902512e-01 0.9338771677 1 148151720 148151749 30 - 0.470 0.467 -0.013
ENSG00000263956 E043 14.0482763 0.0016666573 1.657557e-04 0.0008169288 1 148151750 148152322 573 - 1.299 0.972 -1.177