ENSG00000263280

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000575693 ENSG00000263280 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 1.19105 1.413521 0.8843209 0.1739767 0.08103124 -0.6705996 0.3944065 0.4342605 0.0000000 0.1223172 0.00000000 -5.4733340 0.3214333 0.2963667 0.0000000 -0.29636667 4.771711e-06 4.771711e-06   FALSE
ENST00000662388 ENSG00000263280 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 1.19105 1.413521 0.8843209 0.1739767 0.08103124 -0.6705996 0.3067114 0.4049126 0.6496442 0.2185827 0.04560941 0.6688806 0.2652000 0.2976000 0.7393667 0.44176667 7.067465e-02 4.771711e-06   FALSE
ENST00000691941 ENSG00000263280 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 1.19105 1.413521 0.8843209 0.1739767 0.08103124 -0.6705996 0.2278731 0.2871741 0.1173384 0.1037929 0.02360607 -1.2226412 0.1897125 0.2030667 0.1303333 -0.07273333 7.485448e-01 4.771711e-06   FALSE
ENST00000693688 ENSG00000263280 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 1.19105 1.413521 0.8843209 0.1739767 0.08103124 -0.6705996 0.2278731 0.2871741 0.1173384 0.1037929 0.02360607 -1.2226412 0.1897125 0.2030667 0.1303333 -0.07273333 7.485448e-01 4.771711e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000263280 E001 0.4418608 0.026001563 0.03556055 0.08272964 16 2866325 2866347 23 - 0.351 0.000 -12.563
ENSG00000263280 E002 0.4418608 0.026001563 0.03556055 0.08272964 16 2866348 2866351 4 - 0.351 0.000 -14.455
ENSG00000263280 E003 10.5375850 0.002484084 0.26639801 0.40457652 16 2866352 2866852 501 - 1.115 1.018 -0.353
ENSG00000263280 E004 3.6513200 0.005746056 0.60549714 0.72587700 16 2866853 2866856 4 - 0.712 0.635 -0.325
ENSG00000263280 E005 4.9089432 0.003556905 0.86459936 0.91672453 16 2867461 2867529 69 - 0.777 0.747 -0.118
ENSG00000263280 E006 1.3984277 0.011427332 0.09733434 0.18641022 16 2867530 2867618 89 - 0.151 0.445 2.106
ENSG00000263280 E007 3.4216538 0.155443750 0.49142045 0.62868460 16 2867739 2868091 353 - 0.543 0.647 0.465
ENSG00000263280 E008 4.3940427 0.004557949 0.18149151 0.30311764 16 2868092 2868196 105 - 0.592 0.767 0.738
ENSG00000263280 E009 0.4448795 0.100733821 0.22238050 0.35323829 16 2868197 2868204 8 - 0.000 0.244 12.264
ENSG00000263280 E010 0.4448795 0.100733821 0.22238050 0.35323829 16 2868205 2868251 47 - 0.000 0.244 12.264