ENSG00000263001

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000573035 ENSG00000263001 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2I protein_coding protein_coding 92.3869 70.55148 116.7205 6.113648 4.579051 0.7262286 5.383547 2.710627 11.37644 0.4437772 1.685360 2.06530548 0.05462500 0.0394000 0.0967000 0.05730000 9.511045e-03 1.991006e-11 FALSE TRUE
ENST00000614986 ENSG00000263001 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2I protein_coding protein_coding 92.3869 70.55148 116.7205 6.113648 4.579051 0.7262286 17.015508 9.479983 24.34439 1.8923648 2.248486 1.35970451 0.17466667 0.1330333 0.2078000 0.07476667 1.305798e-01 1.991006e-11 FALSE TRUE
ENST00000620879 ENSG00000263001 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2I protein_coding protein_coding 92.3869 70.55148 116.7205 6.113648 4.579051 0.7262286 37.838747 20.277816 48.70974 7.3969227 1.287084 1.26389289 0.39685417 0.2736000 0.4186667 0.14506667 3.586591e-01 1.991006e-11 FALSE TRUE
MSTRG.30058.11 ENSG00000263001 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2I protein_coding   92.3869 70.55148 116.7205 6.113648 4.579051 0.7262286 3.768483 12.983760 0.00000 4.5665316 0.000000 -10.34360328 0.05142083 0.1980333 0.0000000 -0.19803333 1.991006e-11 1.991006e-11 FALSE TRUE
MSTRG.30058.5 ENSG00000263001 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2I protein_coding   92.3869 70.55148 116.7205 6.113648 4.579051 0.7262286 15.554215 17.886657 16.77836 1.6487973 0.614500 -0.09222853 0.17609583 0.2538333 0.1438000 -0.11003333 3.671545e-11 1.991006e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000263001 E001 0.0000000       7 74650231 74650254 24 +      
ENSG00000263001 E002 0.0000000       7 74650255 74650796 542 +      
ENSG00000263001 E003 0.1451727 0.0425041316 7.609212e-01   7 74651193 74651491 299 + 0.099 0.000 -9.190
ENSG00000263001 E004 1.7005176 0.0099080309 4.580382e-01 5.983586e-01 7 74657667 74657698 32 + 0.486 0.349 -0.739
ENSG00000263001 E005 3.4730440 0.0045258469 3.281312e-02 7.743525e-02 7 74657699 74657699 1 + 0.770 0.422 -1.571
ENSG00000263001 E006 35.3247396 0.0010470499 4.478477e-01 5.892070e-01 7 74657700 74657717 18 + 1.577 1.525 -0.179
ENSG00000263001 E007 106.1507813 0.0005144264 1.740934e-01 2.934947e-01 7 74657718 74657757 40 + 2.049 1.994 -0.185
ENSG00000263001 E008 315.2056086 0.0087484960 8.915709e-05 4.710660e-04 7 74657758 74658030 273 + 2.567 2.378 -0.628
ENSG00000263001 E009 203.9169002 0.0059170118 2.234116e-07 2.122175e-06 7 74658031 74658068 38 + 2.393 2.156 -0.791
ENSG00000263001 E010 5.6004673 0.0028661317 9.068420e-01 9.448459e-01 7 74664458 74664576 119 + 0.824 0.803 -0.082
ENSG00000263001 E011 10.7771479 0.0015456482 3.306335e-01 4.742357e-01 7 74674101 74674345 245 + 1.109 1.002 -0.387
ENSG00000263001 E012 0.0000000       7 74684657 74684904 248 +      
ENSG00000263001 E013 391.8596091 0.0027235125 8.415649e-09 1.051662e-07 7 74689124 74689227 104 + 2.659 2.476 -0.609
ENSG00000263001 E014 584.1619910 0.0001342255 1.886066e-07 1.816151e-06 7 74690973 74691111 139 + 2.797 2.710 -0.291
ENSG00000263001 E015 592.3912022 0.0001164151 1.889402e-01 3.124154e-01 7 74698961 74699095 135 + 2.778 2.752 -0.088
ENSG00000263001 E016 835.6318389 0.0001204004 2.275973e-01 3.595233e-01 7 74700247 74700430 184 + 2.926 2.904 -0.073
ENSG00000263001 E017 454.3965639 0.0004228920 1.900527e-01 3.138421e-01 7 74700606 74700634 29 + 2.666 2.634 -0.105
ENSG00000263001 E018 420.6816668 0.0001827368 8.093936e-01 8.789599e-01 7 74705164 74705176 13 + 2.620 2.617 -0.008
ENSG00000263001 E019 495.5173003 0.0001544325 3.192482e-01 4.623123e-01 7 74705177 74705218 42 + 2.686 2.696 0.034
ENSG00000263001 E020 530.8889644 0.0001160452 5.785340e-02 1.229489e-01 7 74706390 74706433 44 + 2.709 2.733 0.079
ENSG00000263001 E021 530.2115276 0.0002895801 9.282905e-03 2.699172e-02 7 74711032 74711109 78 + 2.702 2.741 0.128
ENSG00000263001 E022 36.7609336 0.0009282985 3.237457e-02 7.658157e-02 7 74714857 74714916 60 + 1.628 1.492 -0.464
ENSG00000263001 E023 0.1472490 0.0429927178 7.601055e-01   7 74714917 74714944 28 + 0.099 0.000 -11.385
ENSG00000263001 E024 1.2878122 0.0105901870 1.000544e-02 2.877552e-02 7 74716612 74716893 282 + 0.099 0.541 3.264
ENSG00000263001 E025 560.1863782 0.0002372805 2.202855e-02 5.573687e-02 7 74716894 74716950 57 + 2.730 2.761 0.104
ENSG00000263001 E026 3.1582911 0.0516498742 1.833807e-02 4.787099e-02 7 74716951 74717066 116 + 0.405 0.801 1.789
ENSG00000263001 E027 271.4871539 0.0013777416 6.516060e-01 7.624353e-01 7 74718879 74718941 63 + 2.428 2.433 0.019
ENSG00000263001 E028 0.6631923 0.5358454563 8.260213e-01 8.905089e-01 7 74728003 74728068 66 + 0.248 0.154 -0.857
ENSG00000263001 E029 539.5917720 0.0001008798 5.265087e-01 6.597360e-01 7 74728786 74728896 111 + 2.726 2.729 0.011
ENSG00000263001 E030 322.5810012 0.0013735837 9.894271e-01 9.974139e-01 7 74730229 74730294 66 + 2.506 2.500 -0.020
ENSG00000263001 E031 363.5866334 0.0016215051 7.450356e-01 8.331843e-01 7 74732479 74732536 58 + 2.561 2.549 -0.043
ENSG00000263001 E032 507.5624436 0.0007886379 1.583277e-01 2.729049e-01 7 74732537 74732662 126 + 2.690 2.713 0.075
ENSG00000263001 E033 0.0000000       7 74733596 74733922 327 +      
ENSG00000263001 E034 445.4154463 0.0001756997 6.165412e-03 1.904730e-02 7 74733923 74733981 59 + 2.624 2.665 0.139
ENSG00000263001 E035 260.9743925 0.0001695171 1.492950e-05 9.533652e-05 7 74735461 74735532 72 + 2.370 2.461 0.303
ENSG00000263001 E036 77.1466433 0.0053450468 3.965168e-03 1.304590e-02 7 74736500 74736502 3 + 1.820 1.966 0.490
ENSG00000263001 E037 127.6247728 0.0027032849 3.644350e-04 1.636356e-03 7 74736503 74736683 181 + 2.041 2.176 0.453
ENSG00000263001 E038 0.0000000       7 74738023 74738044 22 +      
ENSG00000263001 E039 15.1653730 0.0013091808 2.467579e-01 3.821398e-01 7 74738045 74738103 59 + 1.158 1.252 0.335
ENSG00000263001 E040 0.0000000       7 74738104 74738119 16 +      
ENSG00000263001 E041 0.0000000       7 74739806 74740071 266 +      
ENSG00000263001 E042 6.7764057 0.0024567186 5.370487e-01 6.686982e-01 7 74743449 74743520 72 + 0.856 0.925 0.262
ENSG00000263001 E043 0.9620705 0.0129768614 2.577948e-01 3.949659e-01 7 74743521 74743882 362 + 0.359 0.150 -1.644
ENSG00000263001 E044 1.5812806 0.0086686987 9.065556e-01 9.446151e-01 7 74744139 74744250 112 + 0.406 0.423 0.092
ENSG00000263001 E045 0.0000000       7 74744344 74744508 165 +      
ENSG00000263001 E046 0.0000000       7 74744746 74744757 12 +      
ENSG00000263001 E047 5.2274035 0.0055021613 3.298282e-01 4.733746e-01 7 74744758 74744838 81 + 0.730 0.856 0.497
ENSG00000263001 E048 2.3208591 0.0065569121 7.200252e-01 8.147124e-01 7 74744839 74744941 103 + 0.486 0.540 0.263
ENSG00000263001 E049 1.1395084 0.0114756245 6.011262e-01 7.222642e-01 7 74745883 74745941 59 + 0.359 0.261 -0.643
ENSG00000263001 E050 0.1472490 0.0429927178 7.601055e-01   7 74745942 74746055 114 + 0.099 0.000 -11.385
ENSG00000263001 E051 0.0000000       7 74746056 74746336 281 +      
ENSG00000263001 E052 0.5546650 0.0194000918 3.229258e-01 4.662869e-01 7 74746337 74746411 75 + 0.099 0.261 1.679
ENSG00000263001 E053 0.3666179 0.0285783786 7.205162e-01 8.151179e-01 7 74748015 74748116 102 + 0.099 0.150 0.680
ENSG00000263001 E054 0.2903454 0.2848145469 4.520574e-01   7 74749025 74749090 66 + 0.180 0.000 -11.394
ENSG00000263001 E055 0.0000000       7 74749268 74749348 81 +      
ENSG00000263001 E056 0.1515154 0.0423380282 7.601720e-01   7 74749349 74749451 103 + 0.099 0.000 -11.393
ENSG00000263001 E057 0.0000000       7 74749452 74749452 1 +      
ENSG00000263001 E058 0.1515154 0.0423380282 7.601720e-01   7 74751361 74751416 56 + 0.099 0.000 -11.393
ENSG00000263001 E059 11.0503459 0.0016014781 1.391081e-01 2.468400e-01 7 74752090 74752170 81 + 1.011 1.151 0.507
ENSG00000263001 E060 27.7242301 0.0162528955 5.494344e-03 1.727241e-02 7 74753094 74753177 84 + 1.339 1.574 0.812
ENSG00000263001 E061 0.0000000       7 74753845 74753845 1 +      
ENSG00000263001 E062 26.7810413 0.0192110031 1.294727e-04 6.565366e-04 7 74753846 74754029 184 + 1.254 1.604 1.207
ENSG00000263001 E063 0.0000000       7 74754030 74754095 66 +      
ENSG00000263001 E064 0.0000000       7 74754096 74755239 1144 +      
ENSG00000263001 E065 1.0436561 0.0185469892 1.978021e-02 5.102394e-02 7 74755240 74755508 269 + 0.447 0.000 -14.494
ENSG00000263001 E066 26.3970097 0.0062492768 6.889239e-05 3.746973e-04 7 74755509 74755537 29 + 1.279 1.576 1.026
ENSG00000263001 E067 1.5896866 0.0086113337 9.043480e-01 9.430907e-01 7 74755538 74756819 1282 + 0.406 0.423 0.092
ENSG00000263001 E068 42.1990069 0.0242378238 2.279749e-03 8.089223e-03 7 74756820 74756861 42 + 1.495 1.764 0.915
ENSG00000263001 E069 34.4689905 0.0196020160 3.508548e-04 1.583599e-03 7 74757959 74758000 42 + 1.387 1.697 1.060
ENSG00000263001 E070 66.5617527 0.0054789038 1.714668e-06 1.353495e-05 7 74758780 74758855 76 + 1.696 1.956 0.879
ENSG00000263001 E071 90.8297638 0.0147370330 4.185590e-04 1.845480e-03 7 74758856 74759547 692 + 1.839 2.083 0.820
ENSG00000263001 E072 0.0000000       7 74759548 74760692 1145 +