ENSG00000262879

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000570379 ENSG00000262879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA retained_intron 14.03387 16.90054 13.96341 1.032676 0.6737383 -0.2752385 0.2668818 1.0041272 0.0000000 0.5114196 0.00000000 -6.66409478 0.01856250 0.05680000 0.00000000 -0.056800000 1.920514e-01 8.283251e-06   FALSE
ENST00000574741 ENSG00000262879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 14.03387 16.90054 13.96341 1.032676 0.6737383 -0.2752385 2.9935568 4.2127449 2.9618437 0.3154874 0.39228642 -0.50682284 0.20714167 0.24930000 0.21396667 -0.035333333 6.908052e-01 8.283251e-06 TRUE FALSE
ENST00000576938 ENSG00000262879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 14.03387 16.90054 13.96341 1.032676 0.6737383 -0.2752385 1.4252327 3.3542281 0.9554949 0.2427092 0.33188389 -1.80093503 0.09286250 0.19830000 0.06686667 -0.131433333 5.935776e-03 8.283251e-06   FALSE
ENST00000658121 ENSG00000262879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 14.03387 16.90054 13.96341 1.032676 0.6737383 -0.2752385 2.3315877 1.4275079 2.3129929 0.1373457 0.10781526 0.69241482 0.17408333 0.08540000 0.16576667 0.080366667 2.658274e-03 8.283251e-06 FALSE FALSE
ENST00000663210 ENSG00000262879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 14.03387 16.90054 13.96341 1.032676 0.6737383 -0.2752385 0.8701071 0.6167406 1.6393554 0.1560048 0.10714617 1.39596193 0.06276250 0.03566667 0.11726667 0.081600000 8.283251e-06 8.283251e-06   FALSE
MSTRG.14551.33 ENSG00000262879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   14.03387 16.90054 13.96341 1.032676 0.6737383 -0.2752385 1.1616675 0.8380027 0.8108585 0.1351802 0.06256666 -0.04693528 0.08656667 0.04903333 0.05876667 0.009733333 7.575323e-01 8.283251e-06 FALSE FALSE
MSTRG.14551.37 ENSG00000262879 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   14.03387 16.90054 13.96341 1.032676 0.6737383 -0.2752385 0.6437600 1.2074568 0.2480377 0.1733753 0.07885273 -2.23821683 0.04458750 0.07290000 0.01736667 -0.055533333 2.143858e-03 8.283251e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000262879 E001 1.3932309 0.0107416370 1.654721e-01 2.823184e-01 17 46983287 46983416 130 - 0.220 0.467 1.549
ENSG00000262879 E002 1.0266130 0.0125026902 9.933416e-02 1.894733e-01 17 46983417 46983461 45 - 0.124 0.416 2.285
ENSG00000262879 E003 7.9543269 0.0024750437 2.899861e-02 7.000395e-02 17 46983462 46983955 494 - 0.798 1.052 0.962
ENSG00000262879 E004 3.9499958 0.0128452057 3.975811e-01 5.413371e-01 17 46983956 46984044 89 - 0.633 0.763 0.541
ENSG00000262879 E005 1.9090750 0.0284804969 9.523366e-01 9.741513e-01 17 46984045 46984065 21 - 0.474 0.466 -0.039
ENSG00000262879 E006 1.4328726 0.0101058605 7.816508e-01 8.597139e-01 17 46984066 46984069 4 - 0.365 0.416 0.284
ENSG00000262879 E007 0.7268175 0.8386710865 3.048283e-01 4.468546e-01 17 46998062 46998544 483 - 0.000 0.362 11.263
ENSG00000262879 E008 3.7076310 0.0352000484 7.625795e-02 1.535183e-01 17 46998700 46998817 118 - 0.474 0.768 1.297
ENSG00000262879 E009 1.8412441 0.0078539701 4.580167e-03 1.476507e-02 17 47005610 47005784 175 - 0.124 0.624 3.283
ENSG00000262879 E010 2.4626192 0.0066313604 8.002965e-02 1.596033e-01 17 47007840 47007850 11 - 0.365 0.656 1.421
ENSG00000262879 E011 3.7308410 0.0041954306 5.898925e-01 7.128901e-01 17 47007851 47007884 34 - 0.633 0.714 0.340
ENSG00000262879 E012 1.3370057 0.0270908331 9.687862e-01 9.844641e-01 17 47008993 47009256 264 - 0.365 0.359 -0.037
ENSG00000262879 E013 5.0635828 0.0041106158 4.298962e-01 5.725431e-01 17 47009257 47010041 785 - 0.841 0.740 -0.401
ENSG00000262879 E014 14.9230208 0.0252823645 1.783166e-01 2.990284e-01 17 47010070 47010736 667 - 1.110 1.278 0.596
ENSG00000262879 E015 3.9662088 0.0050385180 6.258255e-02 1.309977e-01 17 47016085 47016148 64 - 0.820 0.553 -1.125
ENSG00000262879 E016 10.2808606 0.0074582735 4.608475e-02 1.021926e-01 17 47016149 47016555 407 - 1.162 0.954 -0.756
ENSG00000262879 E017 16.0821229 0.0011931573 3.463900e-03 1.162222e-02 17 47016556 47017660 1105 - 1.351 1.110 -0.851
ENSG00000262879 E018 3.2903310 0.0286731369 1.435757e-01 2.528774e-01 17 47017661 47017662 2 - 0.749 0.511 -1.040
ENSG00000262879 E019 7.0975383 0.0025549977 2.194546e-03 7.824855e-03 17 47017663 47017713 51 - 1.075 0.714 -1.382
ENSG00000262879 E020 4.1038954 0.0039464220 2.600963e-03 9.067640e-03 17 47017714 47017715 2 - 0.899 0.466 -1.845
ENSG00000262879 E021 4.7671128 0.0036538343 1.529020e-02 4.114605e-02 17 47017716 47017717 2 - 0.917 0.590 -1.328
ENSG00000262879 E022 5.2110499 0.0032624768 4.343323e-03 1.410452e-02 17 47017718 47017725 8 - 0.966 0.590 -1.512
ENSG00000262879 E023 30.2689886 0.0025143777 4.830702e-05 2.732153e-04 17 47017726 47018465 740 - 1.622 1.358 -0.905
ENSG00000262879 E024 0.6727692 0.0600193422 9.842914e-01 9.942828e-01 17 47021190 47021581 392 - 0.220 0.216 -0.037
ENSG00000262879 E025 20.2762172 0.0009909202 7.833152e-01 8.609182e-01 17 47021582 47021721 140 - 1.311 1.334 0.080
ENSG00000262879 E026 12.8439982 0.0020416514 9.762162e-01 9.891333e-01 17 47033278 47033319 42 - 1.142 1.141 -0.001
ENSG00000262879 E027 14.5440212 0.0013621867 2.752061e-01 4.144796e-01 17 47033320 47033381 62 - 1.142 1.240 0.349
ENSG00000262879 E028 2.5809984 0.1525097992 4.341362e-01 5.765283e-01 17 47033382 47033646 265 - 0.423 0.604 0.873
ENSG00000262879 E029 2.2636017 0.0070857129 2.645061e-01 4.024665e-01 17 47035044 47035126 83 - 0.598 0.416 -0.885
ENSG00000262879 E030 20.7021601 0.0116624204 3.534243e-03 1.182460e-02 17 47048163 47048360 198 - 1.171 1.440 0.939
ENSG00000262879 E031 143.2724773 0.0004096809 7.889638e-03 2.350218e-02 17 47048361 47051315 2955 - 2.114 2.192 0.261
ENSG00000262879 E032 82.2558186 0.0004046189 2.375699e-10 3.926619e-09 17 47051316 47053461 2146 - 2.033 1.795 -0.799
ENSG00000262879 E033 14.1360724 0.0012322928 3.137611e-02 7.463631e-02 17 47053462 47053718 257 - 1.274 1.088 -0.663
ENSG00000262879 E034 25.2120949 0.0010319647 4.001308e-03 1.314551e-02 17 47053719 47054117 399 - 1.514 1.320 -0.668
ENSG00000262879 E035 22.1994089 0.0009355297 1.345212e-02 3.697017e-02 17 47054118 47054213 96 - 1.448 1.271 -0.613
ENSG00000262879 E036 89.6547493 0.0032838891 1.421205e-08 1.703208e-07 17 47054214 47056206 1993 - 2.076 1.830 -0.826
ENSG00000262879 E037 29.0981143 0.0019642301 1.375801e-02 3.767255e-02 17 47056207 47056455 249 - 1.382 1.548 0.573
ENSG00000262879 E038 16.2889059 0.0011342396 6.885858e-02 1.414810e-01 17 47056456 47056459 4 - 1.152 1.307 0.547
ENSG00000262879 E039 78.5674181 0.0003494659 1.072141e-01 2.014140e-01 17 47056460 47056753 294 - 1.933 1.874 -0.198
ENSG00000262879 E040 6.4742365 0.0026156449 1.420402e-03 5.374617e-03 17 47059983 47060147 165 - 0.598 1.013 1.651
ENSG00000262879 E041 13.3722634 0.0019122086 3.151608e-01 4.579193e-01 17 47067414 47067537 124 - 1.200 1.110 -0.319
ENSG00000262879 E042 1.8801311 0.0145970632 7.386762e-01 8.284961e-01 17 47071446 47071473 28 - 0.474 0.417 -0.297
ENSG00000262879 E043 14.7586824 0.0019982135 4.159994e-08 4.559435e-07 17 47071474 47071612 139 - 0.820 1.359 1.963
ENSG00000262879 E044 9.3225853 0.0020087476 2.338636e-07 2.213136e-06 17 47071613 47071650 38 - 0.561 1.189 2.455
ENSG00000262879 E045 25.2168861 0.0008310432 4.891315e-06 3.489794e-05 17 47072472 47072559 88 - 1.209 1.537 1.139
ENSG00000262879 E046 49.5434384 0.0063344489 1.168303e-04 5.993272e-04 17 47081920 47082350 431 - 1.555 1.797 0.820
ENSG00000262879 E047 33.4461775 0.0011144848 4.786166e-04 2.078119e-03 17 47099835 47099835 1 - 1.410 1.627 0.743
ENSG00000262879 E048 56.8027843 0.0032919648 6.690163e-02 1.382240e-01 17 47099836 47100021 186 - 1.706 1.803 0.329
ENSG00000262879 E049 33.4672813 0.0077054566 1.005251e-01 1.912488e-01 17 47100022 47100248 227 - 1.463 1.581 0.405
ENSG00000262879 E050 7.6934171 0.0040233769 2.216683e-01 3.523876e-01 17 47100255 47100323 69 - 0.841 0.986 0.550