ENSG00000261801

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000562739 ENSG00000261801 HEK293_OSMI2_2hA HEK293_TMG_2hB LOXL1-AS1 lncRNA lncRNA 4.014709 5.53729 4.968586 0.14545 0.2522743 -0.156047 0.8583969 1.3685870 0.9216439 0.29136357 0.16430109 -0.5653397 0.21020833 0.24576667 0.18620000 -0.05956667 6.609125e-01 7.354877e-09 FALSE FALSE
ENST00000562965 ENSG00000261801 HEK293_OSMI2_2hA HEK293_TMG_2hB LOXL1-AS1 lncRNA lncRNA 4.014709 5.53729 4.968586 0.14545 0.2522743 -0.156047 0.3717561 0.2765974 0.6039597 0.05098168 0.05365956 1.0991182 0.09055833 0.05050000 0.12290000 0.07240000 3.723925e-02 7.354877e-09 FALSE FALSE
ENST00000564194 ENSG00000261801 HEK293_OSMI2_2hA HEK293_TMG_2hB LOXL1-AS1 lncRNA lncRNA 4.014709 5.53729 4.968586 0.14545 0.2522743 -0.156047 0.5658089 0.6123958 0.7096173 0.30647815 0.19118523 0.2093975 0.16795000 0.11240000 0.14263333 0.03023333 8.325652e-01 7.354877e-09   FALSE
ENST00000565756 ENSG00000261801 HEK293_OSMI2_2hA HEK293_TMG_2hB LOXL1-AS1 lncRNA lncRNA 4.014709 5.53729 4.968586 0.14545 0.2522743 -0.156047 0.4954213 0.1112580 1.1859707 0.01893987 0.17832901 3.3020296 0.11645417 0.02030000 0.23946667 0.21916667 7.354877e-09 7.354877e-09 FALSE FALSE
ENST00000568087 ENSG00000261801 HEK293_OSMI2_2hA HEK293_TMG_2hB LOXL1-AS1 lncRNA lncRNA 4.014709 5.53729 4.968586 0.14545 0.2522743 -0.156047 0.1824498 0.0744693 0.3570307 0.03768035 0.17893346 2.1194018 0.05526667 0.01366667 0.07103333 0.05736667 6.341877e-01 7.354877e-09 TRUE FALSE
ENST00000685373 ENSG00000261801 HEK293_OSMI2_2hA HEK293_TMG_2hB LOXL1-AS1 lncRNA lncRNA 4.014709 5.53729 4.968586 0.14545 0.2522743 -0.156047 0.4561404 1.0596667 0.2412762 0.13536128 0.15031348 -2.0898155 0.09876250 0.19266667 0.04596667 -0.14670000 1.299899e-01 7.354877e-09 TRUE FALSE
ENST00000688623 ENSG00000261801 HEK293_OSMI2_2hA HEK293_TMG_2hB LOXL1-AS1 lncRNA lncRNA 4.014709 5.53729 4.968586 0.14545 0.2522743 -0.156047 0.8397871 1.8875399 0.6030959 0.36040952 0.13921572 -1.6299456 0.19522500 0.33826667 0.12046667 -0.21780000 1.565433e-02 7.354877e-09 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000261801 E001 0.0000000       15 73908071 73908082 12 -      
ENSG00000261801 E002 2.0962022 0.0672121517 2.505192e-01 3.865617e-01 15 73908083 73908195 113 - 0.328 0.550 1.179
ENSG00000261801 E003 12.9768582 0.0314361161 2.848709e-04 1.318317e-03 15 73908196 73908548 353 - 0.769 1.258 1.811
ENSG00000261801 E004 1.4392153 0.0096463449 8.791505e-01 9.263824e-01 15 73909772 73909850 79 - 0.398 0.382 -0.092
ENSG00000261801 E005 9.3358290 0.0022690669 7.416237e-02 1.501982e-01 15 73912185 73912303 119 - 0.868 1.079 0.785
ENSG00000261801 E006 8.0514122 0.0361743695 6.391127e-03 1.964021e-02 15 73916138 73916199 62 - 0.641 1.081 1.709
ENSG00000261801 E007 14.4797898 0.0377534582 1.380169e-03 5.241432e-03 15 73916200 73916303 104 - 0.846 1.313 1.702
ENSG00000261801 E008 13.3559131 0.0069389779 1.126856e-04 5.802490e-04 15 73916304 73916342 39 - 0.846 1.278 1.579
ENSG00000261801 E009 19.2341182 0.0129189101 2.724184e-06 2.058507e-05 15 73916343 73916447 105 - 0.930 1.435 1.804
ENSG00000261801 E010 34.9214065 0.0008773676 8.794034e-02 1.719905e-01 15 73916448 73917467 1020 - 1.476 1.591 0.396
ENSG00000261801 E011 6.1828248 0.0029578535 5.259017e-01 6.592153e-01 15 73917468 73917595 128 - 0.796 0.890 0.364
ENSG00000261801 E012 87.8812487 0.0020102890 5.056511e-01 6.413895e-01 15 73917596 73918760 1165 - 1.914 1.953 0.130
ENSG00000261801 E013 30.8088220 0.0006922521 4.171386e-02 9.421387e-02 15 73918761 73919027 267 - 1.555 1.448 -0.367
ENSG00000261801 E014 12.4931913 0.0016351101 7.602927e-03 2.277920e-02 15 73919028 73919039 12 - 1.253 1.025 -0.818
ENSG00000261801 E015 22.7532479 0.0011133888 7.106511e-05 3.853087e-04 15 73919040 73919154 115 - 1.512 1.253 -0.899
ENSG00000261801 E016 12.7454673 0.0028052684 4.370151e-03 1.417730e-02 15 73919155 73919160 6 - 1.270 1.024 -0.881
ENSG00000261801 E017 15.5992230 0.0013967944 4.319985e-04 1.897406e-03 15 73919161 73919202 42 - 1.365 1.089 -0.974
ENSG00000261801 E018 20.2556420 0.0011707653 1.519681e-04 7.557196e-04 15 73919203 73919383 181 - 1.465 1.202 -0.914
ENSG00000261801 E019 7.7202897 0.0399103899 1.929740e-01 3.175121e-01 15 73919384 73919837 454 - 1.031 0.857 -0.655
ENSG00000261801 E020 20.6461118 0.0042291442 4.617849e-01 6.016971e-01 15 73919838 73919959 122 - 1.279 1.351 0.250
ENSG00000261801 E021 18.9917145 0.0019045683 4.922323e-02 1.077795e-01 15 73919960 73920038 79 - 1.365 1.226 -0.487
ENSG00000261801 E022 0.9482522 0.2093795218 3.217875e-01 4.650440e-01 15 73925270 73925505 236 - 0.398 0.195 -1.402
ENSG00000261801 E023 0.3729606 0.0316128796 8.193703e-01 8.859446e-01 15 73926240 73926342 103 - 0.138 0.108 -0.410
ENSG00000261801 E024 0.6600969 0.1366457239 7.833091e-01 8.609182e-01 15 73927654 73927776 123 - 0.243 0.195 -0.408
ENSG00000261801 E025 14.9006249 0.0013518751 4.025591e-02 9.150375e-02 15 73927777 73927974 198 - 1.279 1.118 -0.571
ENSG00000261801 E026 0.2214452 0.0433336121 6.370780e-01   15 73928065 73928248 184 - 0.000 0.108 8.950