ENSG00000261609

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000581455 ENSG00000261609 HEK293_OSMI2_2hA HEK293_TMG_2hB GAN protein_coding miRNA 3.121616 2.24273 3.533459 0.5037305 0.07776687 0.6534841 0.8572110 0.4790819 0.9025239 0.13905866 0.09516752 0.899786345 0.2661167 0.2067333 0.2551333 0.0484000 0.735687836 0.002105688 FALSE FALSE
ENST00000648994 ENSG00000261609 HEK293_OSMI2_2hA HEK293_TMG_2hB GAN protein_coding protein_coding 3.121616 2.24273 3.533459 0.5037305 0.07776687 0.6534841 0.9151479 0.3620192 1.1899716 0.02093003 0.07765305 1.689551443 0.2901417 0.1780667 0.3368333 0.1587667 0.031939790 0.002105688 FALSE TRUE
MSTRG.13101.3 ENSG00000261609 HEK293_OSMI2_2hA HEK293_TMG_2hB GAN protein_coding   3.121616 2.24273 3.533459 0.5037305 0.07776687 0.6534841 1.2954360 1.3767438 1.3845156 0.35694937 0.04416755 0.008062736 0.4256875 0.6047000 0.3919333 -0.2127667 0.002105688 0.002105688 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000261609 E001 0.2924217 0.0295523107 4.950569e-01   16 81314944 81314961 18 + 0.157 0.000 -10.186
ENSG00000261609 E002 1.1845624 0.0107412244 2.348209e-02 5.874479e-02 16 81314962 81314988 27 + 0.438 0.000 -13.826
ENSG00000261609 E003 2.5046188 0.0074319875 7.098888e-03 2.148584e-02 16 81314989 81315113 125 + 0.652 0.172 -2.842
ENSG00000261609 E004 4.0006311 0.0040196972 1.612734e-04 7.974812e-04 16 81315114 81315218 105 + 0.824 0.172 -3.543
ENSG00000261609 E005 5.3239217 0.0030994119 4.619590e-04 2.014194e-03 16 81315219 81315280 62 + 0.913 0.391 -2.302
ENSG00000261609 E006 8.4400370 0.0021761673 1.476233e-03 5.560328e-03 16 81351583 81351697 115 + 1.059 0.689 -1.428
ENSG00000261609 E007 0.1472490 0.0435341670 1.000000e+00   16 81351698 81351751 54 + 0.086 0.000 -10.866
ENSG00000261609 E008 19.5297372 0.0009135853 6.908115e-07 5.938477e-06 16 81354405 81354755 351 + 1.401 0.989 -1.467
ENSG00000261609 E009 0.3697384 0.0274424043 6.846622e-02 1.408284e-01 16 81354756 81355115 360 + 0.000 0.295 12.340
ENSG00000261609 E010 12.6647282 0.0015555473 2.895217e-05 1.729053e-04 16 81356785 81357002 218 + 1.228 0.803 -1.573
ENSG00000261609 E011 9.3065647 0.0018189784 1.244929e-03 4.793173e-03 16 81357810 81357931 122 + 1.091 0.730 -1.372
ENSG00000261609 E012 10.3622234 0.0045654702 1.355517e-02 3.720465e-02 16 81362499 81362611 113 + 1.113 0.864 -0.924
ENSG00000261609 E013 12.1512315 0.0167552182 1.466205e-01 2.570903e-01 16 81363794 81363943 150 + 1.148 1.009 -0.503
ENSG00000261609 E014 11.1242057 0.0019479567 1.950583e-02 5.042502e-02 16 81364974 81365110 137 + 1.135 0.918 -0.794
ENSG00000261609 E015 7.1394467 0.0023901256 1.435615e-02 3.903786e-02 16 81365350 81365418 69 + 0.978 0.689 -1.128
ENSG00000261609 E016 5.9130421 0.0026927435 1.313640e-02 3.622256e-02 16 81365419 81365478 60 + 0.913 0.593 -1.302
ENSG00000261609 E017 0.0000000       16 81371863 81372024 162 +      
ENSG00000261609 E018 8.9297535 0.0020915297 3.171930e-02 7.530423e-02 16 81377219 81377328 110 + 1.051 0.834 -0.813
ENSG00000261609 E019 17.2629172 0.0011114111 8.426178e-03 2.485396e-02 16 81377415 81377702 288 + 1.300 1.103 -0.700
ENSG00000261609 E020 133.7411976 0.0207726881 6.208325e-03 1.916332e-02 16 81377703 81385017 7315 + 2.159 2.002 -0.526
ENSG00000261609 E021 174.6297465 0.0003368247 8.343194e-01 8.962615e-01 16 81385018 81389418 4401 + 2.212 2.258 0.154
ENSG00000261609 E022 144.1331297 0.0071214726 3.979137e-27 5.191704e-25 16 81389419 81390809 1391 + 1.914 2.392 1.600