ENSG00000261575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000562555 ENSG00000261575 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 1.224239 1.786706 0.6840026 0.2682582 0.2339242 -1.372341 0.08890625 0.0000000 0.09848742 0.0000000 0.09848742 3.4394558 0.08307083 0.0000000 0.2200 0.22000000 0.72153553 0.01497936   FALSE
ENST00000570002 ENSG00000261575 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.224239 1.786706 0.6840026 0.2682582 0.2339242 -1.372341 0.34208717 1.2264160 0.00000000 0.6672228 0.00000000 -6.9500204 0.24295000 0.6666667 0.0000 -0.66666667 0.43377487 0.01497936   FALSE
ENST00000686646 ENSG00000261575 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.224239 1.786706 0.6840026 0.2682582 0.2339242 -1.372341 0.40309376 0.5602899 0.35198727 0.5602899 0.35198727 -0.6557564 0.25489583 0.3333333 0.3056 -0.02773333 1.00000000 0.01497936   FALSE
ENST00000687508 ENSG00000261575 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.224239 1.786706 0.6840026 0.2682582 0.2339242 -1.372341 0.06647521 0.0000000 0.11676393 0.0000000 0.05534589 3.6640724 0.09295833 0.0000000 0.2372 0.23720000 0.01497936 0.01497936   FALSE
ENST00000692186 ENSG00000261575 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.224239 1.786706 0.6840026 0.2682582 0.2339242 -1.372341 0.12176684 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.16362500 0.0000000 0.0000 0.00000000   0.01497936   FALSE
ENST00000693388 ENSG00000261575 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 1.224239 1.786706 0.6840026 0.2682582 0.2339242 -1.372341 0.06647521 0.0000000 0.11676393 0.0000000 0.05534589 3.6640724 0.09295833 0.0000000 0.2372 0.23720000 0.01497936 0.01497936   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000261575 E001 0.8396112 0.283323694 0.584561285 0.70844026 17 46267030 46267034 5 + 0.324 0.198 -0.938
ENSG00000261575 E002 0.8396112 0.283323694 0.584561285 0.70844026 17 46267035 46267036 2 + 0.324 0.198 -0.938
ENSG00000261575 E003 2.5346253 0.006716249 0.497332758 0.63387266 17 46267037 46267079 43 + 0.425 0.517 0.463
ENSG00000261575 E004 2.1712165 0.007752912 0.724619279 0.81808399 17 46267080 46267082 3 + 0.425 0.464 0.200
ENSG00000261575 E005 11.2154525 0.002286750 0.215033540 0.34448157 17 46267083 46267411 329 + 0.969 1.038 0.256
ENSG00000261575 E006 4.4447444 0.004110580 0.770348375 0.85167560 17 46267412 46267518 107 + 0.735 0.665 -0.289
ENSG00000261575 E007 0.0000000       17 46267519 46267519 1 +      
ENSG00000261575 E008 0.0000000       17 46267520 46267531 12 +      
ENSG00000261575 E009 0.0000000       17 46267532 46267532 1 +      
ENSG00000261575 E010 0.0000000       17 46267533 46267537 5 +      
ENSG00000261575 E011 0.4396707 0.025302484 0.009037329 0.02637157 17 46267538 46267776 239 + 0.425 0.000 -12.484
ENSG00000261575 E012 0.5953508 0.222709174 0.283155304 0.42324170 17 46268504 46268694 191 + 0.324 0.138 -1.571