ENSG00000260404

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000567913 ENSG00000260404 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 8.522875 5.49653 8.236207 0.5514533 0.1760568 0.5825871 1.5993352 1.8367605 1.0626636 0.10895055 0.54688306 -0.7837990 0.19448750 0.34423333 0.12630000 -0.21793333 0.465842254 0.007344916 FALSE TRUE
ENST00000691531 ENSG00000260404 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 8.522875 5.49653 8.236207 0.5514533 0.1760568 0.5825871 0.7820856 0.1883541 0.7535370 0.04337500 0.03878759 1.9446197 0.08647917 0.03400000 0.09136667 0.05736667 0.007344916 0.007344916 TRUE FALSE
MSTRG.25359.1 ENSG00000260404 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   8.522875 5.49653 8.236207 0.5514533 0.1760568 0.5825871 0.4810508 0.4302106 1.0830408 0.24763093 0.62206179 1.3120813 0.06010000 0.07443333 0.13483333 0.06040000 0.926256661 0.007344916 FALSE TRUE
MSTRG.25359.10 ENSG00000260404 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   8.522875 5.49653 8.236207 0.5514533 0.1760568 0.5825871 0.6033759 0.4861532 0.8894123 0.15321932 0.19905021 0.8581970 0.07219167 0.09073333 0.10706667 0.01633333 0.885870124 0.007344916 FALSE TRUE
MSTRG.25359.14 ENSG00000260404 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   8.522875 5.49653 8.236207 0.5514533 0.1760568 0.5825871 1.4311114 0.1444333 1.1112664 0.14443330 0.56165335 2.8600733 0.15963750 0.02236667 0.13586667 0.11350000 0.539771553 0.007344916 FALSE TRUE
MSTRG.25359.19 ENSG00000260404 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   8.522875 5.49653 8.236207 0.5514533 0.1760568 0.5825871 0.9604620 1.1219117 0.8176814 0.14718960 0.17341095 -0.4516140 0.11457500 0.20340000 0.09856667 -0.10483333 0.035224648 0.007344916 FALSE TRUE
MSTRG.25359.4 ENSG00000260404 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   8.522875 5.49653 8.236207 0.5514533 0.1760568 0.5825871 1.5489509 0.9950830 1.7344494 0.25293884 0.30253253 0.7954571 0.18192500 0.17556667 0.21020000 0.03463333 0.802864511 0.007344916 FALSE TRUE
MSTRG.25359.6 ENSG00000260404 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   8.522875 5.49653 8.236207 0.5514533 0.1760568 0.5825871 0.5763320 0.1870785 0.5148386 0.04708724 0.07049118 1.4131033 0.06723750 0.03616667 0.06283333 0.02666667 0.423977290 0.007344916 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000260404 E001 0.0000000       4 118591719 118591723 5 +      
ENSG00000260404 E002 0.0000000       4 118591724 118591726 3 +      
ENSG00000260404 E003 0.6674587 0.0214378152 5.160730e-01 6.506521e-01 4 118591727 118591735 9 + 0.250 0.149 -0.931
ENSG00000260404 E004 0.6674587 0.0214378152 5.160730e-01 6.506521e-01 4 118591736 118591740 5 + 0.250 0.149 -0.931
ENSG00000260404 E005 0.9598804 0.0140494997 2.080981e-01 3.361904e-01 4 118591741 118591751 11 + 0.361 0.149 -1.668
ENSG00000260404 E006 1.1113958 0.0113157081 1.305178e-01 2.348792e-01 4 118591752 118591753 2 + 0.408 0.149 -1.932
ENSG00000260404 E007 2.4925381 0.0319114999 2.023639e-02 5.197986e-02 4 118591754 118591772 19 + 0.666 0.260 -2.153
ENSG00000260404 E008 2.4925381 0.0319114999 2.023639e-02 5.197986e-02 4 118591773 118591773 1 + 0.666 0.260 -2.153
ENSG00000260404 E009 12.1246181 0.0552016066 2.517955e-02 6.224314e-02 4 118591774 118591846 73 + 1.214 0.908 -1.114
ENSG00000260404 E010 14.1445242 0.0168801840 8.269484e-03 2.446520e-02 4 118591847 118591895 49 + 1.265 1.002 -0.946
ENSG00000260404 E011 6.0746970 0.2131282300 4.083608e-01 5.519562e-01 4 118594567 118594684 118 + 0.907 0.724 -0.718
ENSG00000260404 E012 20.9915825 0.0345067976 2.938222e-03 1.008200e-02 4 118595912 118596022 111 + 1.440 1.131 -1.084
ENSG00000260404 E013 0.1817044 0.0393892408 3.423218e-01   4 118596023 118596049 27 + 0.000 0.149 10.348
ENSG00000260404 E014 20.6730118 0.0012872791 4.507933e-06 3.242395e-05 4 118597094 118597225 132 + 1.447 1.108 -1.190
ENSG00000260404 E015 0.0000000       4 118601756 118602076 321 +      
ENSG00000260404 E016 28.6375488 0.0027701604 1.129348e-03 4.402388e-03 4 118605584 118605819 236 + 1.541 1.347 -0.669
ENSG00000260404 E017 0.2955422 0.0298890197 7.872712e-01   4 118605820 118606449 630 + 0.100 0.148 0.649
ENSG00000260404 E018 0.1451727 0.0429074419 6.799056e-01   4 118606450 118606562 113 + 0.100 0.000 -10.542
ENSG00000260404 E019 18.2443109 0.0010640538 4.944190e-02 1.081678e-01 4 118608658 118608722 65 + 1.333 1.207 -0.443
ENSG00000260404 E020 2.7764376 0.0182683034 3.548966e-01 4.992359e-01 4 118608723 118609484 762 + 0.615 0.484 -0.607
ENSG00000260404 E021 19.0461664 0.0053861907 4.941176e-01 6.311080e-01 4 118610949 118611138 190 + 1.311 1.286 -0.087
ENSG00000260404 E022 2.8954988 0.1137920826 7.626595e-01 8.462346e-01 4 118612254 118612358 105 + 0.615 0.578 -0.165
ENSG00000260404 E023 3.3591175 0.0049185398 1.916683e-01 3.158521e-01 4 118617996 118618119 124 + 0.712 0.537 -0.764
ENSG00000260404 E024 8.9634663 0.0039795770 5.351650e-04 2.291351e-03 4 118618166 118618249 84 + 1.121 0.739 -1.443
ENSG00000260404 E025 4.5898757 0.0275457508 9.236128e-02 1.788016e-01 4 118618250 118618378 129 + 0.827 0.587 -0.996
ENSG00000260404 E026 6.5968939 0.0025910644 3.252517e-01 4.686846e-01 4 118619235 118619258 24 + 0.917 0.827 -0.348
ENSG00000260404 E027 15.4686045 0.0067436419 2.794375e-03 9.656979e-03 4 118619259 118619458 200 + 1.305 1.050 -0.911
ENSG00000260404 E028 4.3417948 0.0036694221 3.501947e-01 4.943985e-01 4 118619979 118620076 98 + 0.641 0.800 0.653
ENSG00000260404 E029 2.0767005 0.0271843632 2.003475e-01 3.266541e-01 4 118620414 118620417 4 + 0.556 0.348 -1.082
ENSG00000260404 E030 6.3196242 0.0540214130 2.127383e-01 3.417650e-01 4 118620418 118620468 51 + 0.918 0.745 -0.673
ENSG00000260404 E031 14.3704702 0.0012244549 5.952237e-02 1.258056e-01 4 118620469 118620610 142 + 1.233 1.094 -0.494
ENSG00000260404 E032 11.8884274 0.0014505397 3.221767e-01 4.654785e-01 4 118621463 118621527 65 + 1.129 1.065 -0.232
ENSG00000260404 E033 7.8694824 0.0324498881 2.251224e-01 3.565789e-01 4 118627174 118627292 119 + 0.993 0.855 -0.519
ENSG00000260404 E034 29.1451127 0.0007348570 5.135079e-04 2.210040e-03 4 118628036 118628226 191 + 1.544 1.347 -0.680
ENSG00000260404 E035 20.6370336 0.0008938188 3.122133e-01 4.547478e-01 4 118630289 118630346 58 + 1.348 1.305 -0.151
ENSG00000260404 E036 154.9257478 0.0006500154 9.116909e-02 1.769624e-01 4 118630440 118631560 1121 + 2.191 2.179 -0.041
ENSG00000260404 E037 68.1057677 0.0044191406 6.220892e-01 7.389321e-01 4 118631561 118631814 254 + 1.832 1.842 0.032
ENSG00000260404 E038 338.5561647 0.0023614834 8.354178e-26 9.854757e-24 4 118631815 118633729 1915 + 2.394 2.651 0.858