ENSG00000260260

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000563192 ENSG00000260260 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG19 lncRNA lncRNA 123.0944 243.0124 55.02589 14.52178 2.521861 -2.142645 114.5134 232.144250 48.848867 13.807579 2.3979737 -2.2483914 0.91084583 0.95530000 0.8875667 -0.06773333 2.273749e-09 2.273749e-09    
ENST00000691298 ENSG00000260260 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG19 lncRNA lncRNA 123.0944 243.0124 55.02589 14.52178 2.521861 -2.142645 7.4289 7.016046 6.177024 3.646436 0.4008489 -0.1834674 0.08216667 0.02793333 0.1124333 0.08450000 4.918605e-01 2.273749e-09    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000260260 E001 0.00000       16 2154792 2154796 5 -      
ENSG00000260260 E002 0.00000       16 2154797 2154800 4 -      
ENSG00000260260 E003 0.00000       16 2154801 2154801 1 -      
ENSG00000260260 E004 582.47533 0.0001873554 4.594294e-04 2.004134e-03 16 2154802 2154922 121 - 2.572 2.630 0.193
ENSG00000260260 E005 57.56697 0.0037493096 1.937196e-09 2.720706e-08 16 2154923 2155022 100 - 1.903 1.557 -1.170
ENSG00000260260 E006 37.05439 0.0043659321 7.593104e-06 5.183191e-05 16 2155023 2155024 2 - 1.694 1.381 -1.073
ENSG00000260260 E007 72.84751 0.0009899163 2.098733e-09 2.926963e-08 16 2155025 2155142 118 - 1.959 1.670 -0.977
ENSG00000260260 E008 953.28822 0.0002130137 5.676596e-04 2.412649e-03 16 2155143 2155405 263 - 2.805 2.841 0.120