ENSG00000259768

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000653037 ENSG00000259768 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 2.811527 2.257672 2.727531 0.07204202 0.3702006 0.2716636 0.04887039 0.00000000 0.12762465 0.00000000 0.07221534 3.78266703 0.01883333 0.00000000 0.05206667 0.052066667 0.268580184 0.001229659 FALSE FALSE
ENST00000668995 ENSG00000259768 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 2.811527 2.257672 2.727531 0.07204202 0.3702006 0.2716636 0.15613879 0.09765439 0.09962895 0.05697984 0.07751907 0.02622164 0.05306667 0.04346667 0.03640000 -0.007066667 0.908307945 0.001229659 FALSE FALSE
ENST00000687589 ENSG00000259768 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 2.811527 2.257672 2.727531 0.07204202 0.3702006 0.2716636 0.24919568 0.14968102 0.33603164 0.06756685 0.07825341 1.11571112 0.08454583 0.06516667 0.12126667 0.056100000 0.402333934 0.001229659 TRUE FALSE
ENST00000692742 ENSG00000259768 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 2.811527 2.257672 2.727531 0.07204202 0.3702006 0.2716636 0.04880561 0.17251500 0.00000000 0.04651132 0.00000000 -4.18994313 0.01960417 0.07700000 0.00000000 -0.077000000 0.001229659 0.001229659 FALSE TRUE
MSTRG.12989.12 ENSG00000259768 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   2.811527 2.257672 2.727531 0.07204202 0.3702006 0.2716636 0.40929769 0.17866236 0.39060313 0.09098003 0.13915527 1.08636707 0.13959167 0.07666667 0.13573333 0.059066667 0.571029250 0.001229659 FALSE FALSE
MSTRG.12989.3 ENSG00000259768 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   2.811527 2.257672 2.727531 0.07204202 0.3702006 0.2716636 0.91439912 0.94035414 1.00621609 0.01614999 0.22666738 0.09667008 0.32892500 0.41763333 0.36006667 -0.057566667 0.714456539 0.001229659 TRUE TRUE
MSTRG.12989.8 ENSG00000259768 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   2.811527 2.257672 2.727531 0.07204202 0.3702006 0.2716636 0.58445605 0.62295411 0.29224339 0.12380558 0.19987467 -1.06639013 0.21557500 0.27840000 0.13086667 -0.147533333 0.469875082 0.001229659 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000259768 E001 0.5890081 0.020467575 9.671741e-01 9.834197e-01 16 72665123 72665127 5 + 0.215 0.220 0.040
ENSG00000259768 E002 0.5890081 0.020467575 9.671741e-01 9.834197e-01 16 72665128 72665132 5 + 0.215 0.220 0.040
ENSG00000259768 E003 0.7405235 0.016288080 6.266224e-01 7.425377e-01 16 72665133 72665137 5 + 0.293 0.220 -0.545
ENSG00000259768 E004 0.7405235 0.016288080 6.266224e-01 7.425377e-01 16 72665138 72665139 2 + 0.293 0.220 -0.545
ENSG00000259768 E005 1.5282896 0.011897854 1.891156e-01 3.126244e-01 16 72665140 72665144 5 + 0.511 0.299 -1.182
ENSG00000259768 E006 3.5869941 0.004557003 4.544386e-03 1.466570e-02 16 72665145 72665161 17 + 0.831 0.424 -1.805
ENSG00000259768 E007 4.3608270 0.003699232 4.748612e-02 1.047057e-01 16 72665162 72665167 6 + 0.851 0.599 -1.036
ENSG00000259768 E008 4.6918687 0.003615506 2.368309e-01 3.705161e-01 16 72665168 72665169 2 + 0.831 0.696 -0.543
ENSG00000259768 E009 18.6688844 0.019230999 5.165979e-01 6.511462e-01 16 72665170 72665333 164 + 1.320 1.284 -0.124
ENSG00000259768 E010 20.1511867 0.005041324 7.952573e-01 8.692390e-01 16 72713333 72713416 84 + 1.326 1.331 0.016
ENSG00000259768 E011 9.8883658 0.012268836 2.609322e-01 3.985281e-01 16 72713947 72713989 43 + 1.087 0.982 -0.384
ENSG00000259768 E012 17.6988403 0.013630880 7.767425e-01 8.562485e-01 16 72745405 72745466 62 + 1.239 1.285 0.160
ENSG00000259768 E013 3.7675605 0.005597950 4.375666e-01 5.795199e-01 16 72747017 72747120 104 + 0.589 0.724 0.575
ENSG00000259768 E014 3.9222862 0.091795130 6.510191e-01 7.619750e-01 16 72747121 72747182 62 + 0.714 0.642 -0.302
ENSG00000259768 E015 0.6664265 0.017660540 9.750113e-01 9.884315e-01 16 72777567 72777720 154 + 0.215 0.220 0.043
ENSG00000259768 E016 12.4662816 0.006052932 4.372304e-01 5.792283e-01 16 72781728 72781819 92 + 1.151 1.099 -0.184
ENSG00000259768 E017 1.2492067 0.012722356 1.418335e-01 2.505472e-01 16 72781820 72782731 912 + 0.466 0.220 -1.541
ENSG00000259768 E018 9.7523786 0.031961532 1.338376e-01 2.394882e-01 16 72787163 72787350 188 + 1.110 0.937 -0.634
ENSG00000259768 E019 1.6305733 0.008613650 1.880679e-01 3.112944e-01 16 72787351 72787662 312 + 0.511 0.299 -1.178
ENSG00000259768 E020 164.2818589 0.004366809 4.307903e-06 3.109737e-05 16 72787663 72791624 3962 + 2.140 2.277 0.459
ENSG00000259768 E021 3.6377184 0.004992692 4.838757e-01 6.219050e-01 16 72811928 72812010 83 + 0.713 0.634 -0.336
ENSG00000259768 E022 3.4603570 0.004917129 7.514378e-03 2.255027e-02 16 72820773 72820842 70 + 0.810 0.424 -1.722
ENSG00000259768 E023 7.7342228 0.007462619 1.356255e-01 2.419838e-01 16 72820843 72822049 1207 + 1.013 0.862 -0.566
ENSG00000259768 E024 2.1734989 0.183636049 8.611176e-02 1.691722e-01 16 72822050 72822120 71 + 0.656 0.300 -1.823
ENSG00000259768 E025 1.5384062 0.014739108 1.907531e-01 3.146970e-01 16 72822121 72822781 661 + 0.511 0.299 -1.180
ENSG00000259768 E026 1.7360052 0.007970409 1.163048e-01 2.146875e-01 16 72828007 72828293 287 + 0.552 0.299 -1.372