ENSG00000259343

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000559277 ENSG00000259343 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.367873 5.103597 2.949725 0.2098627 0.131405 -0.7888754 1.1224518 1.82816147 0.5988057 0.37701708 0.30277146 -1.594210 0.32894583 0.353500000 0.2002333 -0.1532667 6.526763e-01 1.399807e-05   FALSE
ENST00000687585 ENSG00000259343 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.367873 5.103597 2.949725 0.2098627 0.131405 -0.7888754 1.5869829 2.79337428 1.3727359 0.06375135 0.20406545 -1.019639 0.44543750 0.550166667 0.4678667 -0.0823000 6.952579e-01 1.399807e-05   FALSE
MSTRG.11366.4 ENSG00000259343 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   3.367873 5.103597 2.949725 0.2098627 0.131405 -0.7888754 0.1640694 0.02886808 0.3626744 0.02886808 0.07984108 3.261258 0.05490417 0.005733333 0.1230000 0.1172667 1.399807e-05 1.399807e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000259343 E001 1.2168251 0.0110462746 0.6638767522 0.771833267 15 81324338 81324341 4 + 0.372 0.288 -0.529
ENSG00000259343 E002 1.3985295 0.0098966488 0.8755971764 0.924102986 15 81324342 81324342 1 + 0.372 0.337 -0.207
ENSG00000259343 E003 1.5468227 0.0088622510 0.9263664802 0.957628613 15 81324343 81324367 25 + 0.372 0.382 0.055
ENSG00000259343 E004 1.5468227 0.0088622510 0.9263664802 0.957628613 15 81324368 81324376 9 + 0.372 0.382 0.055
ENSG00000259343 E005 17.1669694 0.0044346339 0.9365489027 0.964098218 15 81324377 81324437 61 + 1.225 1.223 -0.008
ENSG00000259343 E006 16.8369718 0.0030218654 0.9573658108 0.977268966 15 81324438 81324443 6 + 1.225 1.211 -0.051
ENSG00000259343 E007 25.3223156 0.0008803673 0.6598358192 0.768583247 15 81324444 81324487 44 + 1.364 1.384 0.070
ENSG00000259343 E008 28.1258322 0.0043356760 0.9920608735 0.999139629 15 81324488 81324508 21 + 1.427 1.418 -0.031
ENSG00000259343 E009 23.5002266 0.0029346048 0.9606523942 0.979218822 15 81324509 81324509 1 + 1.356 1.341 -0.051
ENSG00000259343 E010 24.3545984 0.0015970748 0.7979978808 0.871108717 15 81324510 81324513 4 + 1.356 1.363 0.026
ENSG00000259343 E011 34.1040451 0.0005983330 0.3097284323 0.452068402 15 81324514 81324561 48 + 1.469 1.520 0.176
ENSG00000259343 E012 0.1482932 0.0422294993 0.8922184424   15 81324568 81324812 245 + 0.000 0.091 10.882
ENSG00000259343 E013 0.1515154 0.0416248968 0.2648218571   15 81331911 81332023 113 + 0.162 0.000 -13.319
ENSG00000259343 E014 24.4577152 0.0008116302 0.9246081833 0.956527404 15 81332345 81332346 2 + 1.381 1.363 -0.063
ENSG00000259343 E015 50.9595538 0.0005527722 0.3436853090 0.487745713 15 81332347 81332455 109 + 1.651 1.687 0.121
ENSG00000259343 E016 37.7915555 0.0007057921 0.1442184988 0.253742896 15 81332456 81332541 86 + 1.495 1.570 0.256
ENSG00000259343 E017 0.5911836 0.0398859588 0.2340360380 0.367186556 15 81341150 81341219 70 + 0.000 0.232 12.345
ENSG00000259343 E018 46.7831115 0.0040462236 0.1235388550 0.224997986 15 81341562 81341708 147 + 1.580 1.660 0.272
ENSG00000259343 E019 2.7719666 0.0386380193 0.9483071230 0.971559271 15 81341709 81342732 1024 + 0.569 0.552 -0.080
ENSG00000259343 E020 45.9736440 0.0009809560 0.0535142775 0.115401386 15 81342733 81343379 647 + 1.570 1.663 0.317
ENSG00000259343 E021 3.8311541 0.0104380655 0.0002507222 0.001178324 15 81358336 81358503 168 + 0.960 0.421 -2.310
ENSG00000259343 E022 2.9153682 0.0682597617 0.0074018842 0.022264532 15 81361919 81362036 118 + 0.837 0.339 -2.308
ENSG00000259343 E023 0.2966881 0.0290785164 0.0794048197   15 81362037 81362937 901 + 0.279 0.000 -14.284
ENSG00000259343 E024 1.2920680 0.0100867776 0.1155501229 0.213637930 15 81380209 81380254 46 + 0.513 0.231 -1.682
ENSG00000259343 E025 0.3030308 0.2405576776 0.1168452397   15 81380255 81380260 6 + 0.280 0.000 -13.760
ENSG00000259343 E026 0.6674587 0.0327430880 0.1085931056 0.203461720 15 81388105 81388864 760 + 0.372 0.092 -2.527
ENSG00000259343 E027 0.4439371 0.0216708549 0.0235695342 0.058926791 15 81388865 81388991 127 + 0.372 0.000 -14.825
ENSG00000259343 E028 0.7707005 0.7445492758 0.3337749577 0.477523180 15 81388992 81389899 908 + 0.448 0.092 -2.932
ENSG00000259343 E029 2.6741407 0.0071044938 0.0031616813 0.010742719 15 81393078 81395536 2459 + 0.808 0.337 -2.209
ENSG00000259343 E030 2.6041979 0.0103382847 0.0006223444 0.002614599 15 81409115 81410015 901 + 0.837 0.287 -2.648
ENSG00000259343 E031 0.6256415 0.0176386317 0.1048191945 0.197829026 15 81410517 81410602 86 + 0.372 0.092 -2.530
ENSG00000259343 E032 0.2987644 0.0270992084 0.0789943156   15 81410605 81410695 91 + 0.280 0.000 -14.292
ENSG00000259343 E033 0.5975289 0.0233022218 0.0075558203 0.022661002 15 81410696 81410750 55 + 0.448 0.000 -15.169
ENSG00000259343 E034 0.5159433 0.3445910472 0.3662530191 0.510593234 15 81410751 81411267 517 + 0.279 0.093 -1.911
ENSG00000259343 E035 1.0759188 0.0146429001 0.9360093661 0.963765436 15 81418984 81419182 199 + 0.280 0.288 0.056
ENSG00000259343 E036 0.2998086 0.0290088393 0.6470843439   15 81419183 81420357 1175 + 0.162 0.091 -0.948
ENSG00000259343 E037 1.3912458 0.2227908307 0.0124153194 0.034536750 15 81422749 81423883 1135 + 0.662 0.093 -3.917
ENSG00000259343 E038 0.8909948 0.0136708756 0.0154476070 0.041507783 15 81442905 81443291 387 + 0.513 0.091 -3.268
ENSG00000259343 E039 0.1515154 0.0416248968 0.2648218571   15 81516503 81518200 1698 + 0.162 0.000 -13.319