ENSG00000258526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000650949 ENSG00000258526 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5335779 0.4401656 0.4939284 0.06340337 0.07975936 0.1627631 0.03736767 0.030425693 0.08824772 0.030425693 0.05630175 1.281151 0.06545417 0.05370000 0.15080000 0.09710000 0.723210039 0.009508903   FALSE
ENST00000655630 ENSG00000258526 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5335779 0.4401656 0.4939284 0.06340337 0.07975936 0.1627631 0.25632973 0.169270037 0.23715745 0.014854596 0.01479224 0.463296 0.48425833 0.39963333 0.49986667 0.10023333 0.729205777 0.009508903 FALSE FALSE
ENST00000657790 ENSG00000258526 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5335779 0.4401656 0.4939284 0.06340337 0.07975936 0.1627631 0.01624643 0.000000000 0.03823677 0.000000000 0.03823677 2.270133 0.02934167 0.00000000 0.08053333 0.08053333 0.803776662 0.009508903   FALSE
ENST00000662464 ENSG00000258526 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5335779 0.4401656 0.4939284 0.06340337 0.07975936 0.1627631 0.02189244 0.008072136 0.04508222 0.008072136 0.03128381 1.607820 0.04365417 0.02196667 0.11133333 0.08936667 0.739970234 0.009508903   FALSE
ENST00000662828 ENSG00000258526 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5335779 0.4401656 0.4939284 0.06340337 0.07975936 0.1627631 0.02212024 0.041894375 0.00000000 0.026955538 0.00000000 -2.375578 0.03664583 0.10336667 0.00000000 -0.10336667 0.362782987 0.009508903   FALSE
ENST00000666503 ENSG00000258526 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5335779 0.4401656 0.4939284 0.06340337 0.07975936 0.1627631 0.02463827 0.000000000 0.00000000 0.000000000 0.00000000 0.000000 0.06514167 0.00000000 0.00000000 0.00000000   0.009508903   FALSE
ENST00000685977 ENSG00000258526 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5335779 0.4401656 0.4939284 0.06340337 0.07975936 0.1627631 0.06714100 0.108773496 0.00000000 0.033471198 0.00000000 -3.570141 0.11675417 0.23986667 0.00000000 -0.23986667 0.009508903 0.009508903   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000258526 E001 0.0000000       14 39432599 39432606 8 +      
ENSG00000258526 E002 0.1472490 0.049596227 0.89049647   14 39432607 39432611 5 + 0.100 0.000 -10.601
ENSG00000258526 E003 0.4460135 0.023560137 0.20967046 0.33817000 14 39432612 39432626 15 + 0.249 0.000 -14.005
ENSG00000258526 E004 0.5943067 0.019387492 0.58955422 0.71260608 14 39432627 39432630 4 + 0.249 0.149 -0.925
ENSG00000258526 E005 2.3742199 0.006841922 0.06994835 0.14328740 14 39432631 39432646 16 + 0.640 0.348 -1.455
ENSG00000258526 E006 3.1179656 0.005746056 0.03843841 0.08817098 14 39432647 39432660 14 + 0.732 0.421 -1.427
ENSG00000258526 E007 3.5639791 0.005117639 0.01210856 0.03379640 14 39432661 39432675 15 + 0.791 0.421 -1.662
ENSG00000258526 E008 0.0000000       14 39432676 39432738 63 +      
ENSG00000258526 E009 1.9657797 0.012549052 0.05338969 0.11518771 14 39433488 39433729 242 + 0.309 0.630 1.659
ENSG00000258526 E010 0.0000000       14 39434665 39434695 31 +      
ENSG00000258526 E011 0.7500885 0.048294478 0.39053774 0.53449744 14 39436646 39436766 121 + 0.309 0.149 -1.343
ENSG00000258526 E012 0.0000000       14 39447554 39447594 41 +      
ENSG00000258526 E013 0.0000000       14 39468635 39468742 108 +      
ENSG00000258526 E014 5.3945122 0.003615506 0.39381909 0.53771907 14 39470318 39470400 83 + 0.772 0.877 0.411
ENSG00000258526 E015 2.0648542 0.012605249 0.01022171 0.02931251 14 39470401 39470589 189 + 0.249 0.671 2.247
ENSG00000258526 E016 0.5180316 0.021768165 0.03464536 0.08097987 14 39470590 39471095 506 + 0.000 0.348 14.495
ENSG00000258526 E017 0.0000000       14 39474835 39474836 2 +      
ENSG00000258526 E018 0.0000000       14 39474837 39474839 3 +      
ENSG00000258526 E019 0.0000000       14 39474840 39474852 13 +      
ENSG00000258526 E020 0.0000000       14 39474853 39474897 45 +      
ENSG00000258526 E021 0.0000000       14 39474898 39474934 37 +      
ENSG00000258526 E022 0.0000000       14 39474935 39474955 21 +      
ENSG00000258526 E023 0.0000000       14 39479869 39480342 474 +      
ENSG00000258526 E024 0.5932745 0.021051065 0.67237549 0.77835602 14 39485017 39485257 241 + 0.181 0.259 0.659
ENSG00000258526 E025 1.5499457 0.010864776 0.94565074 0.96989728 14 39492255 39492556 302 + 0.407 0.421 0.076
ENSG00000258526 E026 1.2511682 0.013237510 0.54109467 0.67212691 14 39492557 39493340 784 + 0.308 0.421 0.660
ENSG00000258526 E027 0.6652806 0.019387492 0.14726259 0.25796791 14 39493341 39493518 178 + 0.100 0.348 2.246
ENSG00000258526 E028 0.4407149 0.024441170 0.95815798 0.97776521 14 39510813 39511831 1019 + 0.181 0.149 -0.340
ENSG00000258526 E029 1.7056127 0.009204818 0.30508881 0.44712923 14 39513617 39513855 239 + 0.361 0.538 0.922
ENSG00000258526 E030 0.0000000       14 39531228 39531572 345 +      
ENSG00000258526 E031 0.0000000       14 39532780 39532853 74 +      
ENSG00000258526 E032 0.0000000       14 39577280 39577326 47 +      
ENSG00000258526 E033 0.2944980 0.203978408 0.48451582   14 39578202 39578228 27 + 0.181 0.000 -13.563
ENSG00000258526 E034 0.2955422 0.029078516 0.73011676   14 39642713 39642765 53 + 0.100 0.149 0.660
ENSG00000258526 E035 0.4375944 0.174585205 0.23898148 0.37294508 14 39646470 39646571 102 + 0.249 0.000 -13.973
ENSG00000258526 E036 0.1472490 0.049596227 0.89049647   14 39654845 39654940 96 + 0.100 0.000 -12.850
ENSG00000258526 E037 0.6213751 0.023255568 0.59952681 0.72090025 14 39655504 39655808 305 + 0.249 0.149 -0.922
ENSG00000258526 E038 0.1817044 0.346815960 0.30833250   14 39655809 39656356 548 + 0.000 0.150 13.086
ENSG00000258526 E039 0.0000000       14 39711981 39712107 127 +      
ENSG00000258526 E040 0.0000000       14 39854887 39855036 150 +      
ENSG00000258526 E041 0.2214452 0.215131409 0.30160451   14 39991060 39991204 145 + 0.000 0.151 13.143
ENSG00000258526 E042 0.2214452 0.215131409 0.30160451   14 40076512 40078114 1603 + 0.000 0.151 13.143
ENSG00000258526 E043 0.0000000       14 40127570 40127633 64 +      
ENSG00000258526 E044 0.0000000       14 40153311 40153460 150 +      
ENSG00000258526 E045 0.2214452 0.215131409 0.30160451   14 40199203 40200727 1525 + 0.000 0.151 13.143
ENSG00000258526 E046 0.0000000       14 40216527 40216586 60 +      
ENSG00000258526 E047 0.0000000       14 40217829 40217928 100 +      
ENSG00000258526 E048 0.0000000       14 40217929 40217966 38 +      
ENSG00000258526 E049 0.0000000       14 40249688 40249753 66 +      
ENSG00000258526 E050 0.0000000       14 40262616 40262755 140 +      
ENSG00000258526 E051 0.0000000       14 40264815 40264929 115 +      
ENSG00000258526 E052 0.0000000       14 40318436 40318556 121 +      
ENSG00000258526 E053 0.0000000       14 40371521 40371578 58 +      
ENSG00000258526 E054 0.0000000       14 40386252 40386443 192 +      
ENSG00000258526 E055 0.0000000       14 40386444 40386533 90 +      
ENSG00000258526 E056 0.0000000       14 40386534 40386949 416 +      
ENSG00000258526 E057 0.1451727 0.119037262 0.89330062   14 40386950 40387557 608 + 0.100 0.000 -12.840
ENSG00000258526 E058 0.0000000       14 40387558 40388040 483 +      
ENSG00000258526 E059 0.2214452 0.215131409 0.30160451   14 40389077 40390252 1176 + 0.000 0.151 13.143
ENSG00000258526 E060 0.0000000       14 40390253 40390547 295 +