ENSG00000258017

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000548149 ENSG00000258017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.14761 3.83463 1.870242 1.398139 0.2558129 -1.031927 0.09532812 0.6313046 0.0000000 0.6313046 0.00000000 -6.0029378 0.02007083 0.09793333 0.0000000 -0.09793333 8.306650e-01 1.036656e-06   FALSE
ENST00000552893 ENSG00000258017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.14761 3.83463 1.870242 1.398139 0.2558129 -1.031927 0.44193124 1.5285693 0.0000000 0.7730882 0.00000000 -7.2654457 0.11626667 0.33436667 0.0000000 -0.33436667 1.841546e-01 1.036656e-06   FALSE
ENST00000656133 ENSG00000258017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.14761 3.83463 1.870242 1.398139 0.2558129 -1.031927 0.87024918 0.7869966 0.9483196 0.1878983 0.04988623 0.2659334 0.45715833 0.22666667 0.5226333 0.29596667 5.776526e-03 1.036656e-06   FALSE
MSTRG.7236.1 ENSG00000258017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   2.14761 3.83463 1.870242 1.398139 0.2558129 -1.031927 0.47503811 0.7325965 0.4747253 0.2478637 0.23891946 -0.6154113 0.25575833 0.28536667 0.2232667 -0.06210000 9.658579e-01 1.036656e-06 FALSE TRUE
MSTRG.7236.2 ENSG00000258017 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   2.14761 3.83463 1.870242 1.398139 0.2558129 -1.031927 0.12292999 0.0000000 0.3026856 0.0000000 0.03407905 4.9666409 0.06802500 0.00000000 0.1751000 0.17510000 1.036656e-06 1.036656e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000258017 E001 0.0000000       12 49127782 49127785 4 +      
ENSG00000258017 E002 16.0986922 0.138312247 0.002420277 0.008522928 12 49127786 49128010 225 + 0.647 1.380 2.743
ENSG00000258017 E003 18.7662867 0.076193029 0.003536369 0.011830173 12 49128011 49128207 197 + 0.874 1.421 1.968
ENSG00000258017 E004 0.9275265 0.013696863 0.156578500 0.270544651 12 49128208 49128212 5 + 0.402 0.192 -1.450
ENSG00000258017 E005 4.0178279 0.063550267 0.028010544 0.068035713 12 49128213 49128626 414 + 0.873 0.542 -1.380
ENSG00000258017 E006 0.2924217 0.029082988 0.102407281   12 49128627 49128635 9 + 0.246 0.000 -12.025
ENSG00000258017 E007 3.2387069 0.006201577 0.122218382 0.223105664 12 49128636 49128864 229 + 0.714 0.545 -0.738
ENSG00000258017 E008 2.5453387 0.006789270 0.133685519 0.239275179 12 49128865 49128940 76 + 0.646 0.470 -0.812
ENSG00000258017 E009 3.2073851 0.065005622 0.227490152 0.359407956 12 49129245 49129301 57 + 0.715 0.544 -0.742
ENSG00000258017 E010 3.4131250 0.093429525 0.187672251 0.310807966 12 49130909 49130977 69 + 0.744 0.547 -0.852
ENSG00000258017 E011 8.5062665 0.109027010 0.145469651 0.255493339 12 49130978 49131170 193 + 1.066 0.880 -0.691
ENSG00000258017 E012 9.1485321 0.019132217 0.020607072 0.052762471 12 49131171 49131319 149 + 1.107 0.902 -0.756
ENSG00000258017 E013 6.3782243 0.084824990 0.265187104 0.403224108 12 49131320 49131381 62 + 0.953 0.794 -0.611
ENSG00000258017 E014 3.2868021 0.050380076 0.256510641 0.393470426 12 49131606 49131709 104 + 0.463 0.710 1.119
ENSG00000258017 E015 4.3596004 0.036451776 0.449198464 0.590393377 12 49131710 49131825 116 + 0.607 0.778 0.715
ENSG00000258017 E016 1.0329558 0.013696863 0.261338477 0.398976488 12 49147242 49147424 183 + 0.140 0.379 1.873
ENSG00000258017 E017 0.0000000       12 49147633 49147662 30 +      
ENSG00000258017 E018 5.8646074 0.148173972 0.859687152 0.913495298 12 49147663 49150076 2414 + 0.774 0.861 0.340
ENSG00000258017 E019 0.2965864 0.426029874 0.468551752   12 49185917 49185941 25 + 0.000 0.186 10.798
ENSG00000258017 E020 4.5706175 0.004106434 0.004426171 0.014334736 12 49188283 49188484 202 + 0.894 0.578 -1.295