ENSG00000257923

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292538 ENSG00000257923 HEK293_OSMI2_2hA HEK293_TMG_2hB CUX1 protein_coding protein_coding 17.93573 21.53222 18.23297 0.4270874 0.3918503 -0.2398261 1.904909 3.701339 3.0277991 3.7013387 3.02779907 -0.2889132 0.1123333 0.17896667 0.1719333 -0.007033333 1.0000000000 0.0003209449 FALSE  
ENST00000360264 ENSG00000257923 HEK293_OSMI2_2hA HEK293_TMG_2hB CUX1 protein_coding protein_coding 17.93573 21.53222 18.23297 0.4270874 0.3918503 -0.2398261 3.080649 2.871520 3.4513347 0.5639852 0.09734872 0.2644983 0.1757542 0.13240000 0.1892333 0.056833333 0.3205984414 0.0003209449 FALSE  
ENST00000437600 ENSG00000257923 HEK293_OSMI2_2hA HEK293_TMG_2hB CUX1 protein_coding protein_coding 17.93573 21.53222 18.23297 0.4270874 0.3918503 -0.2398261 2.318647 1.817877 3.4574602 0.9361845 0.36061756 0.9237104 0.1332208 0.08283333 0.1889667 0.106133333 0.6042393353 0.0003209449 FALSE  
ENST00000622516 ENSG00000257923 HEK293_OSMI2_2hA HEK293_TMG_2hB CUX1 protein_coding protein_coding 17.93573 21.53222 18.23297 0.4270874 0.3918503 -0.2398261 8.233193 8.162455 6.5889027 4.1033671 3.29543403 -0.3085434 0.4504458 0.37170000 0.3553667 -0.016333333 1.0000000000 0.0003209449 FALSE  
ENST00000646649 ENSG00000257923 HEK293_OSMI2_2hA HEK293_TMG_2hB CUX1 protein_coding protein_coding 17.93573 21.53222 18.23297 0.4270874 0.3918503 -0.2398261 1.393832 2.450359 0.8356663 0.2501023 0.08075371 -1.5407086 0.0757875 0.11383333 0.0460000 -0.067833333 0.0003209449 0.0003209449 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000257923 E001 1.7348593 0.0080128662 2.147191e-01 3.441121e-01 7 101815848 101815861 14 + 0.535 0.346 -0.996
ENSG00000257923 E002 2.9150389 0.0490243611 2.329814e-01 3.659677e-01 7 101815862 101815903 42 + 0.683 0.497 -0.836
ENSG00000257923 E003 3.9835709 0.0317146952 2.435696e-01 3.783714e-01 7 101815904 101815953 50 + 0.768 0.609 -0.664
ENSG00000257923 E004 3.3234871 0.1029636962 3.456804e-01 4.897992e-01 7 101815954 101815959 6 + 0.713 0.542 -0.750
ENSG00000257923 E005 3.9804504 0.0282371942 1.202179e-01 2.203135e-01 7 101815960 101815970 11 + 0.793 0.576 -0.914
ENSG00000257923 E006 8.6136347 0.0032538715 1.228015e-01 2.239564e-01 7 101815971 101816004 34 + 1.044 0.904 -0.520
ENSG00000257923 E007 8.2889477 0.0031224897 1.213088e-01 2.217936e-01 7 101816005 101816006 2 + 1.030 0.887 -0.534
ENSG00000257923 E008 8.7609975 0.0049316000 9.905162e-02 1.890188e-01 7 101816007 101816007 1 + 1.058 0.905 -0.568
ENSG00000257923 E009 8.7609975 0.0049316000 9.905162e-02 1.890188e-01 7 101816008 101816008 1 + 1.058 0.905 -0.568
ENSG00000257923 E010 12.1985605 0.0093792442 1.861983e-01 3.089700e-01 7 101816009 101816010 2 + 1.163 1.058 -0.378
ENSG00000257923 E011 22.3256714 0.0120703055 2.492315e-01 3.850066e-01 7 101816011 101816020 10 + 1.397 1.327 -0.243
ENSG00000257923 E012 77.0588542 0.0006172589 5.390527e-03 1.698889e-02 7 101816021 101816093 73 + 1.931 1.852 -0.267
ENSG00000257923 E013 0.4815130 0.0206895510 6.962734e-01 7.966740e-01 7 101817626 101817633 8 + 0.129 0.207 0.811
ENSG00000257923 E014 0.2998086 0.0300595714 8.764172e-01   7 101817634 101817639 6 + 0.129 0.115 -0.191
ENSG00000257923 E015 0.8983817 0.2597389515 3.775002e-01 5.218339e-01 7 101817640 101817669 30 + 0.379 0.203 -1.232
ENSG00000257923 E016 0.0000000       7 101818921 101818979 59 +      
ENSG00000257923 E017 0.0000000       7 101913104 101913438 335 +      
ENSG00000257923 E018 119.1056531 0.0002938425 3.429515e-04 1.551883e-03 7 101916115 101916225 111 + 2.119 2.037 -0.275
ENSG00000257923 E019 0.2214452 0.0394391150 5.862258e-01   7 101916226 101916587 362 + 0.000 0.116 10.439
ENSG00000257923 E020 0.1482932 0.0420224607 5.882829e-01   7 101932343 101932622 280 + 0.000 0.115 10.406
ENSG00000257923 E021 0.0000000       7 101959390 101959601 212 +      
ENSG00000257923 E022 91.9524759 0.0009241588 2.101296e-01 3.386943e-01 7 102028098 102028145 48 + 1.970 1.956 -0.047
ENSG00000257923 E023 113.8740453 0.0002952941 4.079214e-02 9.249822e-02 7 102070339 102070417 79 + 2.073 2.040 -0.113
ENSG00000257923 E024 142.5163961 0.0004209643 1.061002e-05 7.009717e-05 7 102097364 102097477 114 + 2.204 2.105 -0.333
ENSG00000257923 E025 84.4477431 0.0018269372 8.861572e-05 4.685192e-04 7 102097478 102097501 24 + 1.997 1.864 -0.447
ENSG00000257923 E026 149.3639970 0.0020682685 1.117160e-03 4.360708e-03 7 102104336 102104436 101 + 2.215 2.134 -0.272
ENSG00000257923 E027 97.5400896 0.0003292506 1.068696e-02 3.042197e-02 7 102104437 102104459 23 + 2.019 1.962 -0.192
ENSG00000257923 E028 142.7951227 0.0002724938 2.201925e-03 7.848061e-03 7 102111698 102111774 77 + 2.182 2.125 -0.190
ENSG00000257923 E029 0.1451727 0.0431842959 4.025020e-01   7 102111775 102112010 236 + 0.129 0.000 -11.317
ENSG00000257923 E030 138.1581721 0.0002277776 9.701406e-03 2.802663e-02 7 102115207 102115273 67 + 2.160 2.116 -0.146
ENSG00000257923 E031 0.1817044 0.0399696808 5.871917e-01   7 102115274 102115670 397 + 0.000 0.116 10.431
ENSG00000257923 E032 0.4481018 0.1669894306 7.436583e-01 8.322484e-01 7 102125528 102125778 251 + 0.130 0.204 0.785
ENSG00000257923 E033 121.5478758 0.0004098575 1.085976e-02 3.083003e-02 7 102158560 102158608 49 + 2.108 2.059 -0.163
ENSG00000257923 E034 157.6492314 0.0002174037 4.801412e-03 1.537781e-02 7 102170446 102170550 105 + 2.218 2.173 -0.151
ENSG00000257923 E035 60.7856391 0.0003897086 7.547443e-02 1.522764e-01 7 102178469 102178474 6 + 1.808 1.761 -0.156
ENSG00000257923 E036 189.6571960 0.0004520960 1.133896e-02 3.197576e-02 7 102178475 102178657 183 + 2.290 2.256 -0.112
ENSG00000257923 E037 110.5219659 0.0002796378 6.133338e-01 7.320313e-01 7 102189813 102189871 59 + 2.031 2.048 0.059
ENSG00000257923 E038 96.6153645 0.0003124689 1.463323e-01 2.566800e-01 7 102193842 102193890 49 + 1.928 2.016 0.296
ENSG00000257923 E039 120.2611145 0.0002733901 2.317151e-02 5.810266e-02 7 102195507 102195603 97 + 2.009 2.119 0.369
ENSG00000257923 E040 21.1829840 0.0017971762 1.059565e-03 4.164897e-03 7 102196634 102196866 233 + 1.443 1.227 -0.752
ENSG00000257923 E041 13.9214910 0.0016029457 5.680320e-02 1.211233e-01 7 102196867 102196939 73 + 1.239 1.100 -0.494
ENSG00000257923 E042 50.4178232 0.0010608532 1.625041e-07 1.585432e-06 7 102196940 102197305 366 + 1.819 1.586 -0.790
ENSG00000257923 E043 18.3740970 0.0013180450 1.162143e-04 5.965550e-04 7 102198802 102198867 66 + 1.415 1.140 -0.964
ENSG00000257923 E044 23.6791187 0.0012149366 3.435420e-04 1.554258e-03 7 102200071 102200172 102 + 1.494 1.272 -0.771
ENSG00000257923 E045 88.3962476 0.0039119179 1.641842e-06 1.300941e-05 7 102201360 102202204 845 + 2.043 1.850 -0.649
ENSG00000257923 E046 33.6977003 0.0038318370 3.862682e-03 1.275667e-02 7 102204391 102204556 166 + 1.612 1.456 -0.536
ENSG00000257923 E047 17.9273044 0.0125814182 1.485063e-03 5.588257e-03 7 102205114 102205170 57 + 1.403 1.132 -0.953
ENSG00000257923 E048 47.2065287 0.0071244918 1.169445e-06 9.573820e-06 7 102227367 102227669 303 + 1.814 1.533 -0.954
ENSG00000257923 E049 39.1770922 0.0019273169 3.018816e-03 1.032228e-02 7 102234052 102234240 189 + 1.667 1.528 -0.477
ENSG00000257923 E050 41.1733368 0.0104919769 4.437181e-02 9.905853e-02 7 102239320 102239584 265 + 1.680 1.566 -0.389
ENSG00000257923 E051 50.9177288 0.0201401990 2.951497e-02 7.099921e-02 7 102248412 102249384 973 + 1.786 1.645 -0.477
ENSG00000257923 E052 1422.0236075 0.0017425759 9.822366e-13 2.415078e-11 7 102249385 102258233 8849 + 3.045 3.209 0.545
ENSG00000257923 E053 119.4419622 0.0004467075 4.476728e-04 1.958034e-03 7 102273366 102273493 128 + 1.975 2.130 0.520
ENSG00000257923 E054 8.4303597 0.0042801135 9.435295e-02 1.819123e-01 7 102274174 102274243 70 + 1.044 0.887 -0.585
ENSG00000257923 E055 101.6436680 0.0037767360 2.826841e-02 6.854125e-02 7 102274244 102274310 67 + 1.919 2.057 0.464
ENSG00000257923 E056 125.8661018 0.0009900844 2.931346e-02 7.061284e-02 7 102275247 102275359 113 + 2.028 2.139 0.373
ENSG00000257923 E057 125.3321701 0.0003338315 5.067114e-03 1.611329e-02 7 102277949 102278065 117 + 2.015 2.142 0.425
ENSG00000257923 E058 105.4775113 0.0003573502 1.925721e-01 3.169911e-01 7 102280037 102280120 84 + 1.972 2.053 0.271
ENSG00000257923 E059 98.7457785 0.0110168556 4.802738e-01 6.185684e-01 7 102280804 102280860 57 + 1.997 1.992 -0.017
ENSG00000257923 E060 108.7237881 0.0083982276 7.156861e-01 8.115533e-01 7 102281840 102281920 81 + 2.025 2.043 0.062
ENSG00000257923 E061 94.4613520 0.0067809040 9.489684e-01 9.720002e-01 7 102282712 102282776 65 + 1.956 1.990 0.116
ENSG00000257923 E062 365.5312191 0.0053403128 1.821305e-05 1.140442e-04 7 102283021 102283958 938 + 2.428 2.634 0.686