ENSG00000257103

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000433627 ENSG00000257103 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM14A protein_coding protein_coding 58.90772 25.23372 90.79028 1.817289 2.218403 1.846772 7.384786 6.643152 7.477884 1.453672 1.452442 0.1705202 0.14561667 0.27196667 0.0817000 -0.19026667 0.02308301 0.001820921 FALSE TRUE
ENST00000544216 ENSG00000257103 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM14A protein_coding protein_coding 58.90772 25.23372 90.79028 1.817289 2.218403 1.846772 22.438586 11.175699 35.446107 1.240908 1.694265 1.6643787 0.41095000 0.44393333 0.3911333 -0.05280000 0.70516967 0.001820921 FALSE TRUE
ENST00000585887 ENSG00000257103 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM14A protein_coding non_stop_decay 58.90772 25.23372 90.79028 1.817289 2.218403 1.846772 17.483733 4.983596 26.407196 2.561934 2.183213 2.4033263 0.28901667 0.19053333 0.2900000 0.09946667 0.78746330 0.001820921 FALSE FALSE
ENST00000586157 ENSG00000257103 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM14A protein_coding protein_coding 58.90772 25.23372 90.79028 1.817289 2.218403 1.846772 6.539948 0.376912 10.319747 0.376912 1.062258 4.7386557 0.07363333 0.01306667 0.1143000 0.10123333 0.05266100 0.001820921 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000257103 E001 1.1909051 0.0107954031 4.296848e-02 9.648847e-02 19 34172283 34172433 151 + 0.412 0.000 -12.251
ENSG00000257103 E002 11.5741853 0.0462481015 1.086996e-02 3.085529e-02 19 34172434 34172503 70 + 1.148 0.769 -1.424
ENSG00000257103 E003 33.9340355 0.0240329863 2.304114e-02 5.783318e-02 19 34172504 34172524 21 + 1.562 1.346 -0.743
ENSG00000257103 E004 98.0738922 0.0447195436 1.602448e-02 4.279015e-02 19 34172525 34172567 43 + 2.020 1.783 -0.800
ENSG00000257103 E005 168.0689021 0.0162552944 3.026737e-03 1.034469e-02 19 34172568 34172657 90 + 2.240 2.059 -0.606
ENSG00000257103 E006 340.6525605 0.0004775161 1.850690e-13 5.071716e-12 19 34172658 34172763 106 + 2.540 2.391 -0.495
ENSG00000257103 E007 479.5912326 0.0012117245 1.144185e-10 1.999837e-09 19 34194478 34194641 164 + 2.685 2.558 -0.422
ENSG00000257103 E008 0.1451727 0.0435177567 1.000000e+00   19 34195219 34195320 102 + 0.078 0.000 -9.248
ENSG00000257103 E009 255.2358967 0.0032624696 7.042334e-04 2.914198e-03 19 34196634 34196666 33 + 2.403 2.309 -0.316
ENSG00000257103 E010 342.1328973 0.0009940045 2.558558e-03 8.937733e-03 19 34196667 34196763 97 + 2.517 2.469 -0.160
ENSG00000257103 E011 2.0210400 0.0075244665 2.815504e-01 4.214546e-01 19 34208196 34208928 733 + 0.502 0.316 -1.021
ENSG00000257103 E012 396.6108558 0.0001885466 3.517943e-02 8.198293e-02 19 34208929 34209051 123 + 2.572 2.558 -0.046
ENSG00000257103 E013 470.6413831 0.0011813135 9.777128e-03 2.821398e-02 19 34215124 34215300 177 + 2.651 2.617 -0.114
ENSG00000257103 E014 266.3265347 0.0030152752 2.827741e-02 6.855641e-02 19 34215596 34215657 62 + 2.409 2.355 -0.180
ENSG00000257103 E015 107.4199017 0.0078221530 6.441456e-01 7.565027e-01 19 34215658 34215661 4 + 1.987 2.033 0.157
ENSG00000257103 E016 306.6524521 0.0008394851 4.262118e-02 9.585288e-02 19 34219391 34219573 183 + 2.429 2.506 0.256
ENSG00000257103 E017 125.8638016 0.0003456934 7.729491e-01 8.534678e-01 19 34219706 34219708 3 + 2.059 2.096 0.124
ENSG00000257103 E018 433.7799797 0.0001981546 8.510742e-03 2.506466e-02 19 34219709 34219877 169 + 2.580 2.655 0.253
ENSG00000257103 E019 0.8815316 0.0130885136 9.490264e-02 1.827340e-01 19 34221350 34221506 157 + 0.340 0.000 -11.833
ENSG00000257103 E020 528.1476390 0.0015974107 1.690976e-01 2.870144e-01 19 34221507 34221738 232 + 2.671 2.727 0.188
ENSG00000257103 E021 0.2966881 0.0270638259 6.138586e-01   19 34221739 34221779 41 + 0.145 0.000 -10.249
ENSG00000257103 E022 82.8619486 0.0004584805 1.955287e-02 5.052351e-02 19 34226408 34226464 57 + 1.848 1.972 0.417
ENSG00000257103 E023 150.8501965 0.0002441777 4.943540e-02 1.081566e-01 19 34227365 34227368 4 + 2.118 2.206 0.295
ENSG00000257103 E024 1396.9567529 0.0032252831 2.062260e-11 4.076897e-10 19 34227369 34229288 1920 + 3.047 3.229 0.607