ENSG00000256612

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000541697 ENSG00000256612 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2B7P transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 0.09961543 0.1790457 0.1278648 0.0323948 0.01183773 -0.4554811 0.011127462 0.000000000 0.00000000 0.000000000 0.00000000 0.000000 0.14571364 0.00000000 0.0000000 0.0000000   0.01499372 TRUE TRUE
ENST00000593298 ENSG00000256612 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2B7P transcribed_unprocessed_pseudogene retained_intron 0.09961543 0.1790457 0.1278648 0.0323948 0.01183773 -0.4554811 0.022316529 0.043304973 0.00000000 0.022024998 0.00000000 -2.414270 0.27595455 0.30010000 0.0000000 -0.3001000 0.42562862 0.01499372 FALSE TRUE
ENST00000599831 ENSG00000256612 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2B7P transcribed_unprocessed_pseudogene retained_intron 0.09961543 0.1790457 0.1278648 0.0323948 0.01183773 -0.4554811 0.011435283 0.000000000 0.03582511 0.000000000 0.02069620 2.196138 0.11745455 0.00000000 0.2612667 0.2612667 0.32252062 0.01499372 FALSE TRUE
ENST00000600518 ENSG00000256612 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2B7P transcribed_unprocessed_pseudogene retained_intron 0.09961543 0.1790457 0.1278648 0.0323948 0.01183773 -0.4554811 0.018949089 0.008884016 0.09203966 0.008884016 0.01242281 2.433893 0.25886364 0.04153333 0.7387333 0.6972000 0.01499372 0.01499372   FALSE
ENST00000686248 ENSG00000256612 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2B7P transcribed_unprocessed_pseudogene processed_transcript 0.09961543 0.1790457 0.1278648 0.0323948 0.01183773 -0.4554811 0.028993667 0.102207790 0.00000000 0.052952778 0.00000000 -3.488101 0.13167727 0.48443333 0.0000000 -0.4844333 0.15274164 0.01499372   FALSE
ENST00000693208 ENSG00000256612 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2B7P transcribed_unprocessed_pseudogene processed_transcript 0.09961543 0.1790457 0.1278648 0.0323948 0.01183773 -0.4554811 0.004352125 0.024648913 0.00000000 0.012713136 0.00000000 -1.792810 0.04056818 0.17393333 0.0000000 -0.1739333 0.60502425 0.01499372 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000256612 E001 0.0000000       19 40924219 40924245 27 +      
ENSG00000256612 E002 0.0000000       19 40924246 40924247 2 +      
ENSG00000256612 E003 0.0000000       19 40924248 40924272 25 +      
ENSG00000256612 E004 0.5514428 0.02182743 0.0579046083 0.123039743 19 40924273 40924443 171 + 0.000 0.403 13.036
ENSG00000256612 E005 0.3299976 0.03175890 0.1604329547   19 40928696 40928883 188 + 0.000 0.305 14.697
ENSG00000256612 E006 0.7665583 0.06541441 0.0246987909 0.061260956 19 40936097 40936259 163 + 0.000 0.485 15.547
ENSG00000256612 E007 0.5483223 0.02548956 0.4886755292 0.626206579 19 40936392 40936541 150 + 0.082 0.306 2.300
ENSG00000256612 E008 0.1515154 0.05489683 0.5259700977   19 40938969 40939129 161 + 0.082 0.000 -11.109
ENSG00000256612 E009 0.5180316 0.02889444 0.0590641813 0.125025497 19 40939130 40939517 388 + 0.000 0.403 15.193
ENSG00000256612 E010 0.2987644 0.03481674 0.2160758479   19 40941296 40941422 127 + 0.151 0.000 -11.870
ENSG00000256612 E011 0.1472490 0.05413433 0.5271963452   19 40941423 40941472 50 + 0.082 0.000 -11.109
ENSG00000256612 E012 0.2987644 0.03481674 0.2160758479   19 40941473 40941868 396 + 0.151 0.000 -11.870
ENSG00000256612 E013 0.0000000       19 40942065 40942206 142 +      
ENSG00000256612 E014 0.2955422 0.03604062 0.9381193056   19 40944143 40944330 188 + 0.082 0.179 1.294
ENSG00000256612 E015 0.2955422 0.03604062 0.9381193056   19 40944331 40944518 188 + 0.082 0.179 1.294
ENSG00000256612 E016 0.1482932 0.05321187 0.4329856011   19 40944711 40944852 142 + 0.000 0.179 13.886
ENSG00000256612 E017 0.0000000       19 40944853 40944988 136 +      
ENSG00000256612 E018 1.8415257 0.03264919 0.0008125928 0.003304071 19 40949053 40950676 1624 + 0.516 0.179 -2.158