ENSG00000256269

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536185 ENSG00000256269 HEK293_OSMI2_2hA HEK293_TMG_2hB HMBS protein_coding processed_transcript 98.8981 177.1553 56.22581 10.9055 2.248638 -1.655535 11.33093 19.14142 7.00132 2.341428 2.8579229 -1.449693 0.1129750 0.1072667 0.1207000 0.01343333 0.97529670 1.93538e-06   FALSE
ENST00000652429 ENSG00000256269 HEK293_OSMI2_2hA HEK293_TMG_2hB HMBS protein_coding protein_coding 98.8981 177.1553 56.22581 10.9055 2.248638 -1.655535 68.65762 131.84292 33.43733 4.438582 0.7247234 -1.978967 0.6644208 0.7473333 0.5964667 -0.15086667 0.01408235 1.93538e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000256269 E001 14.784367 0.0018485004 6.690408e-01 7.759513e-01 11 119084866 119084880 15 + 1.128 1.094 -0.120
ENSG00000256269 E002 15.154106 0.0016090915 7.508581e-01 8.374464e-01 11 119084881 119084882 2 + 1.128 1.106 -0.078
ENSG00000256269 E003 15.778700 0.0012020478 8.773633e-01 9.252171e-01 11 119084883 119084884 2 + 1.128 1.123 -0.016
ENSG00000256269 E004 21.722421 0.0009377032 6.027508e-01 7.236654e-01 11 119084885 119084887 3 + 1.279 1.244 -0.122
ENSG00000256269 E005 59.233027 0.0046331011 3.496576e-03 1.171484e-02 11 119084888 119084897 10 + 1.800 1.632 -0.569
ENSG00000256269 E006 102.810251 0.0063266560 4.106235e-01 5.542277e-01 11 119084898 119084899 2 + 1.931 1.897 -0.116
ENSG00000256269 E007 171.264708 0.0010671722 1.701463e-03 6.287784e-03 11 119084900 119084906 7 + 2.200 2.102 -0.331
ENSG00000256269 E008 181.783105 0.0014986803 1.598123e-03 5.955381e-03 11 119084907 119084908 2 + 2.228 2.127 -0.337
ENSG00000256269 E009 186.524739 0.0016420366 9.485291e-04 3.782755e-03 11 119084909 119084910 2 + 2.244 2.138 -0.356
ENSG00000256269 E010 268.314506 0.0001911757 2.775971e-01 4.171884e-01 11 119084911 119084913 3 + 2.330 2.313 -0.057
ENSG00000256269 E011 270.595419 0.0001869828 3.587547e-01 5.031239e-01 11 119084914 119084914 1 + 2.330 2.318 -0.041
ENSG00000256269 E012 472.630793 0.0001536404 9.772425e-01 9.898291e-01 11 119084915 119084929 15 + 2.552 2.564 0.040
ENSG00000256269 E013 704.495144 0.0007450741 5.037005e-01 6.396648e-01 11 119084930 119084998 69 + 2.712 2.741 0.095
ENSG00000256269 E014 617.710271 0.0006402951 3.045355e-01 4.465464e-01 11 119084999 119085030 32 + 2.685 2.677 -0.025
ENSG00000256269 E015 472.543792 0.0001898434 7.891346e-03 2.350653e-02 11 119085031 119085039 9 + 2.596 2.554 -0.140
ENSG00000256269 E016 581.571613 0.0011203569 7.136270e-01 8.100669e-01 11 119085040 119085066 27 + 2.648 2.654 0.020
ENSG00000256269 E017 24.512176 0.0008111108 1.250355e-03 4.810990e-03 11 119085067 119085157 91 + 1.480 1.240 -0.833
ENSG00000256269 E018 2.034554 0.1610215325 2.119680e-02 5.400746e-02 11 119085222 119085222 1 + 0.776 0.266 -2.560
ENSG00000256269 E019 3.000891 0.0064761152 1.337031e-05 8.625500e-05 11 119085223 119085243 21 + 0.958 0.306 -2.980
ENSG00000256269 E020 3.516846 0.0048546703 1.360886e-04 6.861729e-04 11 119085244 119085270 27 + 0.958 0.404 -2.395
ENSG00000256269 E021 4.439062 0.0093125992 2.011940e-06 1.564359e-05 11 119085271 119085289 19 + 1.086 0.432 -2.713
ENSG00000256269 E022 7.459762 0.0022526623 9.274951e-12 1.943493e-10 11 119085290 119085539 250 + 1.319 0.551 -2.957
ENSG00000256269 E023 7.215068 0.0173665110 1.193229e-04 6.108071e-04 11 119085540 119085782 243 + 1.166 0.677 -1.862
ENSG00000256269 E024 3.390361 0.0625640975 2.055779e-02 5.266762e-02 11 119085783 119085810 28 + 0.858 0.458 -1.734
ENSG00000256269 E025 6.916784 0.0525381235 8.418181e-04 3.408200e-03 11 119085811 119085893 83 + 1.167 0.658 -1.945
ENSG00000256269 E026 20.434470 0.0135772251 1.327048e-09 1.922646e-08 11 119087266 119087982 717 + 1.610 1.057 -1.935
ENSG00000256269 E027 3.880166 0.0133026674 9.365043e-03 2.719465e-02 11 119087983 119087983 1 + 0.894 0.507 -1.626
ENSG00000256269 E028 3.581402 0.0060570857 3.860979e-02 8.846876e-02 11 119087984 119087986 3 + 0.819 0.507 -1.335
ENSG00000256269 E029 3.729695 0.0083348598 5.427981e-02 1.167372e-01 11 119087987 119087994 8 + 0.819 0.529 -1.229
ENSG00000256269 E030 5.366611 0.0131911437 9.618229e-04 3.827794e-03 11 119087995 119088078 84 + 1.039 0.591 -1.779
ENSG00000256269 E031 5.539976 0.0030509252 2.847963e-09 3.882127e-08 11 119088079 119088174 96 + 1.201 0.459 -2.989
ENSG00000256269 E032 3.119662 0.0114160138 6.282140e-07 5.448577e-06 11 119088175 119088178 4 + 1.013 0.268 -3.447
ENSG00000256269 E033 5.505038 0.0499765104 4.805887e-05 2.719661e-04 11 119088179 119088253 75 + 1.147 0.510 -2.542
ENSG00000256269 E034 4.149406 0.0047285226 1.157781e-02 3.253165e-02 11 119088254 119088254 1 + 0.894 0.530 -1.515
ENSG00000256269 E035 719.800344 0.0014362362 9.308785e-01 9.605079e-01 11 119088255 119088308 54 + 2.732 2.749 0.058
ENSG00000256269 E036 4.671907 0.0088652023 2.751653e-04 1.278618e-03 11 119088309 119088385 77 + 1.013 0.508 -2.067
ENSG00000256269 E037 11.052334 0.0015518244 2.082160e-07 1.989203e-06 11 119088386 119088634 249 + 1.345 0.832 -1.864
ENSG00000256269 E038 783.017897 0.0016283013 1.085559e-01 2.034102e-01 11 119088635 119088707 73 + 2.735 2.792 0.189
ENSG00000256269 E039 20.574706 0.0010594380 8.339361e-14 2.399360e-12 11 119088708 119088848 141 + 1.617 1.051 -1.979
ENSG00000256269 E040 26.456884 0.0060458857 1.684562e-14 5.375361e-13 11 119088849 119089081 233 + 1.726 1.151 -1.987
ENSG00000256269 E041 466.939041 0.0023863774 5.388584e-01 6.702279e-01 11 119089082 119089099 18 + 2.528 2.564 0.119
ENSG00000256269 E042 475.467927 0.0014895463 1.406722e-01 2.489415e-01 11 119089100 119089131 32 + 2.585 2.561 -0.082
ENSG00000256269 E043 11.953718 0.0018108897 5.230988e-05 2.933240e-04 11 119089132 119089216 85 + 1.306 0.912 -1.427
ENSG00000256269 E044 597.470888 0.0001199458 4.796255e-02 1.055707e-01 11 119089217 119089272 56 + 2.683 2.660 -0.078
ENSG00000256269 E045 811.871364 0.0001127765 6.044770e-01 7.250211e-01 11 119089683 119089760 78 + 2.792 2.797 0.015
ENSG00000256269 E046 3.022788 0.0092233750 1.117987e-04 5.760582e-04 11 119089761 119089775 15 + 0.927 0.341 -2.641
ENSG00000256269 E047 8.072867 0.0294593704 2.230608e-06 1.717324e-05 11 119089776 119089989 214 + 1.279 0.662 -2.328
ENSG00000256269 E048 906.254532 0.0002161920 6.856948e-01 7.883649e-01 11 119089990 119090067 78 + 2.839 2.845 0.023
ENSG00000256269 E049 793.417468 0.0001420094 8.544016e-02 1.681161e-01 11 119090190 119090265 76 + 2.753 2.794 0.138
ENSG00000256269 E050 12.595577 0.0015132121 3.079480e-13 8.160556e-12 11 119091163 119091256 94 + 1.480 0.810 -2.419
ENSG00000256269 E051 875.717243 0.0001285795 2.796545e-02 6.794622e-02 11 119091413 119091526 114 + 2.792 2.839 0.159
ENSG00000256269 E052 12.990715 0.0174338407 6.764116e-01 7.813906e-01 11 119091527 119091537 11 + 0.987 1.057 0.257
ENSG00000256269 E053 33.422921 0.0200134759 7.046696e-05 3.823830e-04 11 119091538 119091860 323 + 1.695 1.342 -1.208
ENSG00000256269 E054 6.296506 0.0119775434 9.737410e-09 1.203499e-07 11 119091861 119091874 14 + 1.234 0.508 -2.862
ENSG00000256269 E055 23.884259 0.0022161784 4.525490e-13 1.174278e-11 11 119091875 119092124 250 + 1.654 1.124 -1.841
ENSG00000256269 E056 512.868752 0.0010418582 1.408205e-02 3.840941e-02 11 119092125 119092163 39 + 2.537 2.614 0.255
ENSG00000256269 E057 54.205538 0.0054694280 1.042975e-12 2.552492e-11 11 119092164 119092403 240 + 1.938 1.520 -1.418
ENSG00000256269 E058 814.245085 0.0015315862 1.893298e-03 6.893177e-03 11 119092404 119092523 120 + 2.726 2.817 0.304
ENSG00000256269 E059 19.726876 0.0171495745 7.818228e-08 8.105619e-07 11 119092524 119092610 87 + 1.576 1.062 -1.798
ENSG00000256269 E060 27.529689 0.0192911834 3.408193e-07 3.118134e-06 11 119092611 119092757 147 + 1.683 1.223 -1.585
ENSG00000256269 E061 753.766894 0.0020693787 4.822044e-04 2.092108e-03 11 119092758 119092811 54 + 2.675 2.787 0.371
ENSG00000256269 E062 7.363170 0.0109465345 3.403414e-02 7.982570e-02 11 119092812 119092934 123 + 1.039 0.773 -1.011
ENSG00000256269 E063 970.736459 0.0014346431 1.507789e-06 1.205156e-05 11 119092935 119093021 87 + 2.771 2.898 0.424
ENSG00000256269 E064 1611.586554 0.0020628794 2.276839e-04 1.082030e-03 11 119093110 119093834 725 + 3.013 3.115 0.339