ENSG00000255624

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368895 ENSG00000255624 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88B transcribed_processed_pseudogene transcribed_processed_pseudogene 2.109377 1.191835 3.081084 0.1901609 0.1957753 1.362874 0.36307302 0.13976970 0.35703168 0.02489578 0.14047494 1.29315886 0.18206667 0.11933333 0.1130333 -0.00630000 1.000000e+00 2.086953e-05 FALSE TRUE
ENST00000425266 ENSG00000255624 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88B transcribed_processed_pseudogene processed_transcript 2.109377 1.191835 3.081084 0.1901609 0.1957753 1.362874 0.17275546 0.23509107 0.41134262 0.03908741 0.18554538 0.78167593 0.08219167 0.22120000 0.1422333 -0.07896667 7.129263e-01 2.086953e-05 FALSE TRUE
MSTRG.4761.3 ENSG00000255624 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88B transcribed_processed_pseudogene   2.109377 1.191835 3.081084 0.1901609 0.1957753 1.362874 0.36930081 0.24059660 0.70646993 0.12480212 0.03840576 1.51553933 0.16788333 0.17360000 0.2303333 0.05673333 8.245806e-01 2.086953e-05 FALSE TRUE
MSTRG.4761.4 ENSG00000255624 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88B transcribed_processed_pseudogene   2.109377 1.191835 3.081084 0.1901609 0.1957753 1.362874 0.85544256 0.53174693 1.02517424 0.07759625 0.27837260 0.93418265 0.38017917 0.45456667 0.3289667 -0.12560000 5.533568e-01 2.086953e-05 TRUE TRUE
MSTRG.4761.6 ENSG00000255624 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88B transcribed_processed_pseudogene   2.109377 1.191835 3.081084 0.1901609 0.1957753 1.362874 0.06993785 0.04463068 0.04668875 0.04463068 0.04668875 0.05335108 0.06580417 0.03133333 0.0141000 -0.01723333 8.168336e-01 2.086953e-05 FALSE TRUE
MSTRG.4761.7 ENSG00000255624 HEK293_OSMI2_2hA HEK293_TMG_2hB C10orf88B transcribed_processed_pseudogene   2.109377 1.191835 3.081084 0.1901609 0.1957753 1.362874 0.24965233 0.00000000 0.53437659 0.00000000 0.09943422 5.76653313 0.09710417 0.00000000 0.1712333 0.17123333 2.086953e-05 2.086953e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000255624 E001 0.5159433 0.2568733860 1.00000000 1.00000000 10 122879681 122879705 25 + 0.167 0.164 -0.039
ENSG00000255624 E002 0.6611159 0.0221967535 0.70186165 0.80083829 10 122879706 122879715 10 + 0.232 0.162 -0.647
ENSG00000255624 E003 0.6611159 0.0221967535 0.70186165 0.80083829 10 122879716 122879720 5 + 0.232 0.162 -0.647
ENSG00000255624 E004 2.7271187 0.0057592453 0.94136349 0.96714604 10 122879721 122879760 40 + 0.555 0.568 0.061
ENSG00000255624 E005 7.7845492 0.0023143050 0.78688228 0.86352755 10 122879851 122880011 161 + 0.943 0.914 -0.109
ENSG00000255624 E006 2.5569684 0.0070319008 0.65068040 0.76169363 10 122880074 122880116 43 + 0.583 0.511 -0.330
ENSG00000255624 E007 5.1628598 0.0032960557 0.46655864 0.60610392 10 122880347 122880371 25 + 0.738 0.836 0.388
ENSG00000255624 E008 8.0520899 0.0022226702 0.59860612 0.72015504 10 122880372 122880447 76 + 0.919 0.980 0.229
ENSG00000255624 E009 12.2068858 0.0016516499 0.72415562 0.81776521 10 122880671 122880739 69 + 1.098 1.133 0.128
ENSG00000255624 E010 9.2071287 0.0118362224 0.81824866 0.88513095 10 122880740 122880756 17 + 1.007 0.980 -0.100
ENSG00000255624 E011 1.6553645 0.0089441922 0.90074800 0.94069529 10 122880757 122880873 117 + 0.423 0.447 0.126
ENSG00000255624 E012 13.8697113 0.0015637722 0.64610571 0.75810916 10 122881598 122881667 70 + 1.144 1.187 0.154
ENSG00000255624 E013 0.2987644 0.0280415464 0.45258006   10 122883725 122883931 207 + 0.168 0.001 -8.156
ENSG00000255624 E014 11.3869507 0.0065553497 0.18912837 0.31264280 10 122884717 122884852 136 + 1.018 1.149 0.476
ENSG00000255624 E015 30.0939124 0.0008799242 0.01494921 0.04037125 10 122888269 122888723 455 + 1.537 1.395 -0.488
ENSG00000255624 E016 3.9825402 0.0048131004 0.57329950 0.69923369 10 122890746 122890853 108 + 0.656 0.740 0.350
ENSG00000255624 E017 1.4832251 0.0090614027 0.31327734 0.45583888 10 122894692 122894721 30 + 0.460 0.279 -1.067
ENSG00000255624 E018 23.3413260 0.0153962375 0.42955342 0.57225961 10 122897793 122898716 924 + 1.351 1.422 0.246