ENSG00000254860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000532599 ENSG00000254860 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM9B-AS1 lncRNA lncRNA 3.328604 3.933627 3.607304 0.872714 0.1895726 -0.1246082 0.3879883 0.1088061 1.01236285 0.10880612 0.40041563 3.10522621 0.1107792 0.01966667 0.27386667 0.254200000 0.041880540 0.003418078 FALSE FALSE
ENST00000534349 ENSG00000254860 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM9B-AS1 lncRNA lncRNA 3.328604 3.933627 3.607304 0.872714 0.1895726 -0.1246082 0.6695009 1.1962348 0.49526738 0.64420917 0.49526738 -1.25539179 0.1834000 0.25626667 0.14346667 -0.112800000 0.547455567 0.003418078 FALSE FALSE
ENST00000657967 ENSG00000254860 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM9B-AS1 lncRNA lncRNA 3.328604 3.933627 3.607304 0.872714 0.1895726 -0.1246082 0.4179861 0.2203603 0.58977404 0.04465680 0.03646331 1.38052712 0.1281292 0.05640000 0.16536667 0.108966667 0.003418078 0.003418078   FALSE
ENST00000686329 ENSG00000254860 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM9B-AS1 lncRNA lncRNA 3.328604 3.933627 3.607304 0.872714 0.1895726 -0.1246082 0.4524808 0.3630026 0.38443048 0.08052958 0.01885195 0.08058533 0.1410583 0.09750000 0.10713333 0.009633333 0.906242630 0.003418078   FALSE
MSTRG.5134.3 ENSG00000254860 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM9B-AS1 lncRNA   3.328604 3.933627 3.607304 0.872714 0.1895726 -0.1246082 0.9544878 1.4992555 0.88573993 0.28910074 0.17739414 -0.75268522 0.2886167 0.38566667 0.24400000 -0.141666667 0.189435452 0.003418078 FALSE FALSE
MSTRG.5134.6 ENSG00000254860 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM9B-AS1 lncRNA   3.328604 3.933627 3.607304 0.872714 0.1895726 -0.1246082 0.2438733 0.3571144 0.08742832 0.35711441 0.08742832 -1.91381663 0.0857625 0.14096667 0.02583333 -0.115133333 1.000000000 0.003418078 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000254860 E001 0.4031496 0.0240297991 2.103971e-01 3.390127e-01 11 8964502 8964506 5 + 0.000 0.212 11.422
ENSG00000254860 E002 0.4031496 0.0240297991 2.103971e-01 3.390127e-01 11 8964507 8964509 3 + 0.000 0.212 11.423
ENSG00000254860 E003 11.1642894 0.0015747818 8.396246e-02 1.657483e-01 11 8964510 8964674 165 + 0.974 1.133 0.582
ENSG00000254860 E004 17.6869570 0.0011153219 4.889069e-01 6.264165e-01 11 8964675 8964889 215 + 1.234 1.278 0.152
ENSG00000254860 E005 8.6283293 0.0021469323 8.965699e-02 1.745981e-01 11 8964890 8964940 51 + 0.869 1.044 0.655
ENSG00000254860 E006 12.8065811 0.0017406104 9.563254e-01 9.766390e-01 11 8964941 8965047 107 + 1.129 1.123 -0.020
ENSG00000254860 E007 18.9897624 0.0010891907 8.625982e-01 9.153965e-01 11 8965048 8965148 101 + 1.290 1.292 0.005
ENSG00000254860 E008 10.4475312 0.0360456829 9.602762e-01 9.789881e-01 11 8965149 8965903 755 + 1.058 1.047 -0.039
ENSG00000254860 E009 28.1084031 0.0007971396 8.875632e-01 9.321259e-01 11 8965904 8966044 141 + 1.451 1.449 -0.009
ENSG00000254860 E010 6.2155051 0.0030389172 1.193907e-01 2.190752e-01 11 8966045 8966502 458 + 0.730 0.916 0.728
ENSG00000254860 E011 14.5207658 0.0014258404 8.859390e-01 9.310409e-01 11 8966541 8966579 39 + 1.180 1.181 0.003
ENSG00000254860 E012 14.4694724 0.0013508828 9.406976e-01 9.667326e-01 11 8966580 8966656 77 + 1.190 1.172 -0.063
ENSG00000254860 E013 21.8422111 0.0009840220 1.098340e-01 2.053238e-01 11 8967839 8968041 203 + 1.283 1.386 0.359
ENSG00000254860 E014 29.5174685 0.0112065790 2.985640e-08 3.361869e-07 11 8968042 8971123 3082 + 1.664 1.242 -1.453
ENSG00000254860 E015 3.2431888 0.0050028739 1.540800e-01 2.672147e-01 11 8976165 8976283 119 + 0.730 0.506 -0.989
ENSG00000254860 E016 0.8179419 0.0148155624 6.268810e-01 7.427582e-01 11 8977419 8977424 6 + 0.303 0.212 -0.682
ENSG00000254860 E017 12.5235142 0.0110085126 4.765989e-03 1.527857e-02 11 8977425 8977716 292 + 0.925 1.218 1.068