ENSG00000254087

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420292 ENSG00000254087 HEK293_OSMI2_2hA HEK293_TMG_2hB LYN protein_coding processed_transcript 7.811619 5.854452 13.60903 0.02908541 0.6638998 1.215556 1.110284 0.6234446 2.368610 0.31884424 0.7698278 1.90882831 0.1072792 0.1061000 0.1695333 0.06343333 7.382901e-01 2.591405e-45 FALSE FALSE
ENST00000519728 ENSG00000254087 HEK293_OSMI2_2hA HEK293_TMG_2hB LYN protein_coding protein_coding 7.811619 5.854452 13.60903 0.02908541 0.6638998 1.215556 2.885265 3.5278989 3.346101 0.27066132 0.2724126 -0.07610676 0.4535708 0.6029333 0.2470333 -0.35590000 4.236725e-06 2.591405e-45 FALSE TRUE
ENST00000520050 ENSG00000254087 HEK293_OSMI2_2hA HEK293_TMG_2hB LYN protein_coding protein_coding 7.811619 5.854452 13.60903 0.02908541 0.6638998 1.215556 2.274121 0.0000000 5.549537 0.00000000 0.1911800 9.11882098 0.2193625 0.0000000 0.4084000 0.40840000 2.591405e-45 2.591405e-45 FALSE FALSE
ENST00000520220 ENSG00000254087 HEK293_OSMI2_2hA HEK293_TMG_2hB LYN protein_coding protein_coding 7.811619 5.854452 13.60903 0.02908541 0.6638998 1.215556 1.541949 1.7031085 2.344784 0.02761616 0.3617241 0.45897838 0.2197833 0.2909333 0.1750333 -0.11590000 1.025954e-01 2.591405e-45 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000254087 E001 38.723958 0.0025887766 1.059606e-07 1.071466e-06 8 55879835 55880103 269 + 1.695 1.441 -0.866
ENSG00000254087 E002 0.000000       8 55940234 55940327 94 +      
ENSG00000254087 E003 51.690294 0.0058079155 1.568771e-03 5.857867e-03 8 55941855 55941928 74 + 1.769 1.652 -0.397
ENSG00000254087 E004 39.571492 0.0006051457 6.041085e-05 3.334689e-04 8 55941929 55941991 63 + 1.670 1.522 -0.504
ENSG00000254087 E005 62.103071 0.0015246120 9.515741e-04 3.793142e-03 8 55946448 55946493 46 + 1.832 1.752 -0.271
ENSG00000254087 E006 77.415036 0.0003596054 1.065117e-05 7.033962e-05 8 55947618 55947723 106 + 1.936 1.839 -0.329
ENSG00000254087 E007 71.396074 0.0003390236 2.753025e-06 2.078229e-05 8 55950459 55950557 99 + 1.912 1.796 -0.391
ENSG00000254087 E008 77.679400 0.0006773258 1.187506e-07 1.189999e-06 8 55950681 55950784 104 + 1.958 1.821 -0.462
ENSG00000254087 E009 90.841497 0.0003184511 1.172957e-05 7.670192e-05 8 55951966 55952115 150 + 2.003 1.921 -0.275
ENSG00000254087 E010 94.634493 0.0085616010 3.142721e-01 4.569821e-01 8 55953832 55953984 153 + 1.972 1.994 0.072
ENSG00000254087 E011 0.584854 0.0774899292 7.122496e-02 1.453743e-01 8 55955096 55955293 198 + 0.000 0.332 10.946
ENSG00000254087 E012 108.837514 0.0032153710 3.375546e-01 4.814400e-01 8 55966715 55966897 183 + 2.024 2.060 0.121
ENSG00000254087 E013 78.458527 0.0050758705 3.271587e-01 4.706128e-01 8 55969717 55969793 77 + 1.886 1.910 0.082
ENSG00000254087 E014 94.320075 0.0005510518 1.298076e-01 2.338922e-01 8 55998346 55998499 154 + 1.910 2.043 0.444
ENSG00000254087 E015 89.942053 0.0003650053 3.245693e-03 1.098934e-02 8 55999418 55999549 132 + 1.862 2.047 0.623
ENSG00000254087 E016 522.496505 0.0096900378 7.543786e-08 7.844270e-07 8 56009908 56014169 4262 + 2.575 2.839 0.878