ENSG00000253741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000520572 ENSG00000253741 HEK293_OSMI2_2hA HEK293_TMG_2hB LNCOC1 lncRNA lncRNA 0.2620153 0.2512264 0.453172 0.02709498 0.07012409 0.8262477 0.125665513 0.11100270 0.26813446 0.01909221 0.06992430 1.200743 0.52019167 0.4630333 0.60506667 0.1420333 0.69697589 0.04494168 FALSE TRUE
ENST00000662059 ENSG00000253741 HEK293_OSMI2_2hA HEK293_TMG_2hB LNCOC1 lncRNA lncRNA 0.2620153 0.2512264 0.453172 0.02709498 0.07012409 0.8262477 0.010582711 0.00000000 0.05854459 0.00000000 0.05854459 2.777043 0.03396250 0.0000000 0.10976667 0.1097667 0.86010317 0.04494168 TRUE FALSE
ENST00000665898 ENSG00000253741 HEK293_OSMI2_2hA HEK293_TMG_2hB LNCOC1 lncRNA lncRNA 0.2620153 0.2512264 0.453172 0.02709498 0.07012409 0.8262477 0.017765964 0.00000000 0.02435219 0.00000000 0.02435219 1.780402 0.06432083 0.0000000 0.07770000 0.0777000 0.91695986 0.04494168 FALSE TRUE
ENST00000669349 ENSG00000253741 HEK293_OSMI2_2hA HEK293_TMG_2hB LNCOC1 lncRNA lncRNA 0.2620153 0.2512264 0.453172 0.02709498 0.07012409 0.8262477 0.035587065 0.07739337 0.02958967 0.02316562 0.01491246 -1.142400 0.11752917 0.2961667 0.05653333 -0.2396333 0.09894925 0.04494168 FALSE TRUE
ENST00000686139 ENSG00000253741 HEK293_OSMI2_2hA HEK293_TMG_2hB LNCOC1 lncRNA lncRNA 0.2620153 0.2512264 0.453172 0.02709498 0.07012409 0.8262477 0.007803592 0.00000000 0.06242874 0.00000000 0.03554432 2.856562 0.01483333 0.0000000 0.11866667 0.1186667 0.38468560 0.04494168 FALSE FALSE
ENST00000689400 ENSG00000253741 HEK293_OSMI2_2hA HEK293_TMG_2hB LNCOC1 lncRNA lncRNA 0.2620153 0.2512264 0.453172 0.02709498 0.07012409 0.8262477 0.044598967 0.06283028 0.01012239 0.02181418 0.01012239 -1.855737 0.18718333 0.2408667 0.03230000 -0.2085667 0.04494168 0.04494168 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000253741 E001 0.7770552 0.015513831 0.41734720 0.56072156 8 142701857 142702251 395 - 0.191 0.332 1.053
ENSG00000253741 E002 0.1515154 0.043844091 0.64537882   8 142702252 142702272 21 - 0.106 0.000 -8.646
ENSG00000253741 E003 2.5086922 0.006965799 0.51160551 0.64659152 8 142702273 142702588 316 - 0.507 0.609 0.468
ENSG00000253741 E004 17.2148041 0.028367177 0.92444724 0.95640359 8 142702589 142705317 2729 - 1.258 1.261 0.009
ENSG00000253741 E005 1.9982339 0.144609007 0.46993211 0.60914970 8 142705318 142705379 62 - 0.378 0.529 0.782
ENSG00000253741 E006 2.2927319 0.136864065 0.74944852 0.83640611 8 142705380 142705503 124 - 0.468 0.529 0.295
ENSG00000253741 E007 3.6190293 0.007031880 0.94080443 0.96681626 8 142705504 142705999 496 - 0.662 0.648 -0.059
ENSG00000253741 E008 8.3634036 0.002272400 0.01295211 0.03579854 8 142706000 142707067 1068 - 1.071 0.804 -1.008
ENSG00000253741 E009 3.5169611 0.005117639 0.32638393 0.46982294 8 142707068 142707391 324 - 0.712 0.566 -0.629
ENSG00000253741 E010 3.6502770 0.005117639 0.87203517 0.92170951 8 142707392 142707579 188 - 0.662 0.684 0.091
ENSG00000253741 E011 3.6868061 0.004793704 0.03646979 0.08447769 8 142708315 142708418 104 - 0.507 0.804 1.277
ENSG00000253741 E012 0.0000000       8 142720556 142720590 35 -      
ENSG00000253741 E013 0.1451727 0.060197077 0.64321226   8 142721283 142721346 64 - 0.106 0.000 -8.636
ENSG00000253741 E014 1.5929062 0.010016337 0.13415229 0.23992094 8 142723634 142723722 89 - 0.262 0.519 1.472
ENSG00000253741 E015 1.4113036 0.015332099 0.80162493 0.87359820 8 142724658 142724738 81 - 0.377 0.333 -0.262
ENSG00000253741 E016 0.6717251 0.018928979 0.48867501 0.62620658 8 142725527 142725528 2 - 0.262 0.141 -1.113
ENSG00000253741 E017 2.7450129 0.009012784 0.36000900 0.50431927 8 142725529 142726721 1193 - 0.507 0.648 0.638
ENSG00000253741 E018 1.4026967 0.010864776 0.87518475 0.92381696 8 142726722 142726744 23 - 0.377 0.403 0.147
ENSG00000253741 E019 1.9938829 0.007878450 0.40918139 0.55279317 8 142726745 142727047 303 - 0.543 0.403 -0.701