ENSG00000253320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000519257 ENSG00000253320 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.243699 3.582361 3.094306 0.164416 0.2163118 -0.2106615 0.14779821 0.22726222 0.1490424 0.02436863 0.03264279 -0.5770707 0.09182500 0.06370000 0.0471000 -0.01660000 0.7654805797 0.0001077794   FALSE
ENST00000520455 ENSG00000253320 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.243699 3.582361 3.094306 0.164416 0.2163118 -0.2106615 0.06641532 0.00000000 0.2195395 0.00000000 0.15872890 4.5206708 0.03138333 0.00000000 0.0714000 0.07140000 0.2257898042 0.0001077794 FALSE FALSE
ENST00000522850 ENSG00000253320 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.243699 3.582361 3.094306 0.164416 0.2163118 -0.2106615 0.14181475 0.08708619 0.0000000 0.04386688 0.00000000 -3.2792662 0.12138750 0.02396667 0.0000000 -0.02396667 0.1166553567 0.0001077794   FALSE
ENST00000524007 ENSG00000253320 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.243699 3.582361 3.094306 0.164416 0.2163118 -0.2106615 1.19162603 2.51951851 1.2029054 0.22859961 0.18777837 -1.0603958 0.46616667 0.70050000 0.3837667 -0.31673333 0.0001077794 0.0001077794   FALSE
MSTRG.31945.3 ENSG00000253320 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   2.243699 3.582361 3.094306 0.164416 0.2163118 -0.2106615 0.43208322 0.40607544 1.0108110 0.05061368 0.04966755 1.2947987 0.17676250 0.11440000 0.3312000 0.21680000 0.0004015539 0.0001077794 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000253320 E001 0.9264943 0.015120478 8.412052e-01 9.009407e-01 8 102864271 102864279 9 + 0.282 0.310 0.194
ENSG00000253320 E002 0.9254501 0.013587763 5.367221e-01 6.684486e-01 8 102864280 102864299 20 + 0.346 0.229 -0.805
ENSG00000253320 E003 0.7675920 0.016250084 7.964767e-01 8.700936e-01 8 102864300 102864313 14 + 0.281 0.229 -0.389
ENSG00000253320 E004 1.6972067 0.009367698 5.676645e-01 6.944353e-01 8 102864314 102864336 23 + 0.401 0.489 0.457
ENSG00000253320 E005 5.2984025 0.003498335 1.194994e-01 2.192301e-01 8 102864337 102864440 104 + 0.695 0.882 0.744
ENSG00000253320 E006 4.8628713 0.003651584 3.086082e-02 7.364636e-02 8 102864441 102864457 17 + 0.606 0.882 1.122
ENSG00000253320 E007 18.1094506 0.001490410 1.113816e-02 3.149764e-02 8 102864458 102864623 166 + 1.184 1.354 0.596
ENSG00000253320 E008 1.1446155 0.078565871 3.742495e-03 1.241776e-02 8 102864911 102864994 84 + 0.000 0.532 12.655
ENSG00000253320 E009 15.9224068 0.001499523 7.358258e-08 7.668610e-07 8 102865103 102865319 217 + 0.964 1.386 1.507
ENSG00000253320 E010 4.1977601 0.004060847 1.053198e-02 3.004897e-02 8 102879895 102879897 3 + 0.868 0.490 -1.610
ENSG00000253320 E011 4.3450091 0.003956671 6.920061e-03 2.101678e-02 8 102879898 102879915 18 + 0.886 0.490 -1.678
ENSG00000253320 E012 9.9506706 0.001859125 1.515699e-01 2.638032e-01 8 102879916 102880058 143 + 1.109 0.955 -0.565
ENSG00000253320 E013 0.2903454 0.255058500 3.220905e-01   8 102880059 102880214 156 + 0.206 0.000 -11.954
ENSG00000253320 E014 0.2924217 0.029078516 2.550476e-01   8 102882310 102882487 178 + 0.206 0.000 -12.148
ENSG00000253320 E015 2.9076891 0.005732768 4.055341e-01 5.492130e-01 8 102885132 102885609 478 + 0.536 0.651 0.518
ENSG00000253320 E016 3.5678521 0.005168520 1.650463e-02 4.385224e-02 8 102885610 102885713 104 + 0.811 0.438 -1.651
ENSG00000253320 E017 0.4427912 0.142579062 7.005016e-01 7.999561e-01 8 102887078 102887093 16 + 0.206 0.129 -0.815
ENSG00000253320 E018 0.0000000       8 102903792 102903877 86 +      
ENSG00000253320 E019 0.7708142 0.015491856 2.333644e-01 3.664031e-01 8 102904224 102904274 51 + 0.346 0.130 -1.803
ENSG00000253320 E020 1.8318721 0.009647244 3.846653e-01 5.288251e-01 8 102904275 102904385 111 + 0.535 0.379 -0.804
ENSG00000253320 E021 0.6569633 0.025801840 4.078668e-01 5.514616e-01 8 102904386 102904502 117 + 0.281 0.130 -1.385
ENSG00000253320 E022 1.5028049 0.039331870 3.342702e-01 4.780043e-01 8 102905064 102905295 232 + 0.495 0.310 -1.030
ENSG00000253320 E023 0.0000000       8 102925032 102925123 92 +      
ENSG00000253320 E024 0.0000000       8 102930182 102930518 337 +      
ENSG00000253320 E025 0.0000000       8 102935995 102936130 136 +      
ENSG00000253320 E026 0.0000000       8 102937433 102937623 191 +      
ENSG00000253320 E027 1.4382729 0.009862906 1.449373e-01 2.547544e-01 8 102937624 102937681 58 + 0.495 0.230 -1.610
ENSG00000253320 E028 1.0382438 0.013235221 7.783626e-02 1.560044e-01 8 102937682 102937757 76 + 0.451 0.130 -2.390
ENSG00000253320 E029 0.0000000       8 102941623 102941698 76 +      
ENSG00000253320 E030 1.6252773 0.008484319 8.033496e-03 2.386467e-02 8 102941921 102942053 133 + 0.606 0.130 -3.126
ENSG00000253320 E031 0.7363589 0.015653349 2.684975e-02 6.568107e-02 8 102967597 102967673 77 + 0.401 0.000 -13.126
ENSG00000253320 E032 0.0000000       8 102972321 102972371 51 +      
ENSG00000253320 E033 2.6584380 0.061076546 6.749051e-04 2.807306e-03 8 102977587 102978784 1198 + 0.790 0.129 -3.895
ENSG00000253320 E034 0.3030308 0.449932606 3.698291e-01   8 102978785 102978955 171 + 0.207 0.000 -11.831
ENSG00000253320 E035 0.0000000       8 102992250 102992407 158 +      
ENSG00000253320 E036 0.0000000       8 102995625 102995682 58 +      
ENSG00000253320 E037 1.2639685 0.301116434 3.563155e-01 5.006928e-01 8 103000009 103002424 2416 + 0.452 0.231 -1.387