ENSG00000253123

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000624599 ENSG00000253123 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA TEC 1.486478 2.570653 1.36712 0.08764242 0.09206268 -0.9060815 0.26415114 0.5853048 0.1182751 0.06409830 0.11827510 -2.2143874 0.18676250 0.22656667 0.07706667 -0.1495000 0.25026000 0.0108688   FALSE
ENST00000655057 ENSG00000253123 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 1.486478 2.570653 1.36712 0.08764242 0.09206268 -0.9060815 0.02841311 0.0000000 0.1260355 0.00000000 0.12603551 3.7659114 0.01810417 0.00000000 0.08210000 0.0821000 0.69405151 0.0108688   FALSE
ENST00000661295 ENSG00000253123 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA lncRNA 1.486478 2.570653 1.36712 0.08764242 0.09206268 -0.9060815 0.19409433 0.2049026 0.2792422 0.05969010 0.08428168 0.4285952 0.16328333 0.07840000 0.21396667 0.1355667 0.32504028 0.0108688   FALSE
MSTRG.31387.3 ENSG00000253123 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   1.486478 2.570653 1.36712 0.08764242 0.09206268 -0.9060815 0.62672794 1.5779749 0.4033344 0.09596169 0.06586295 -1.9418068 0.34791250 0.61600000 0.30156667 -0.3144333 0.01086880 0.0108688   FALSE
MSTRG.31387.4 ENSG00000253123 HEK293_OSMI2_2hA HEK293_TMG_2hB lncRNA   1.486478 2.570653 1.36712 0.08764242 0.09206268 -0.9060815 0.22933772 0.1047049 0.4402331 0.10470486 0.13562259 1.9727456 0.17921667 0.03853333 0.32533333 0.2868000 0.06552754 0.0108688   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000253123 E001 2.0262462 0.0222061887 0.82395942 0.88907986 8 37326575 37326605 31 - 0.474 0.433 -0.213
ENSG00000253123 E002 19.0812532 0.0011849994 0.44738794 0.58878875 8 37326606 37327438 833 - 1.297 1.237 -0.213
ENSG00000253123 E003 14.9159608 0.0013880610 0.04224860 0.09517767 8 37327439 37327584 146 - 0.996 1.197 0.725
ENSG00000253123 E004 20.9824085 0.0009443139 0.48975328 0.62714466 8 37327585 37327680 96 - 1.252 1.306 0.191
ENSG00000253123 E005 17.7824525 0.0011042398 0.61124453 0.73038026 8 37327681 37327717 37 - 1.252 1.209 -0.151
ENSG00000253123 E006 13.7039240 0.0013776492 0.57718142 0.70247299 8 37327718 37327719 2 - 1.158 1.106 -0.187
ENSG00000253123 E007 29.3460017 0.0007341360 0.89852315 0.93928307 8 37327720 37327935 216 - 1.428 1.436 0.028
ENSG00000253123 E008 7.3223951 0.0169014924 0.96478583 0.98179982 8 37327936 37328707 772 - 0.872 0.881 0.035
ENSG00000253123 E009 11.4134414 0.0024845430 0.60102027 0.72218725 8 37328708 37328804 97 - 0.996 1.052 0.203
ENSG00000253123 E010 4.7875161 0.0039849971 0.61383814 0.73245714 8 37328805 37328832 28 - 0.775 0.704 -0.288
ENSG00000253123 E011 2.8785454 0.0058295861 0.02635233 0.06465042 8 37328833 37329025 193 - 0.775 0.433 -1.536
ENSG00000253123 E012 3.4092639 0.0425681935 0.02969161 0.07135320 8 37329026 37329403 378 - 0.842 0.493 -1.495
ENSG00000253123 E013 10.6343375 0.0019121334 0.84402466 0.90289359 8 37329404 37329641 238 - 0.996 1.017 0.077
ENSG00000253123 E014 5.3383140 0.1013072979 0.55716051 0.68563625 8 37329642 37329730 89 - 0.650 0.770 0.494
ENSG00000253123 E015 6.8534265 0.0026585719 0.41448383 0.55790028 8 37329731 37329885 155 - 0.775 0.882 0.418
ENSG00000253123 E016 23.8040450 0.0016031189 0.56100484 0.68891306 8 37329886 37330590 705 - 1.318 1.361 0.149
ENSG00000253123 E017 3.7588518 0.0043486240 0.97036562 0.98544533 8 37330591 37330671 81 - 0.650 0.645 -0.022
ENSG00000253123 E018 8.2362398 0.0023071294 0.32325648 0.46656629 8 37330672 37331166 495 - 0.996 0.882 -0.429
ENSG00000253123 E019 0.2965864 0.1585762069 0.59315064   8 37331767 37331793 27 - 0.000 0.152 8.630
ENSG00000253123 E020 0.6298062 0.0180218402 0.83522789 0.89689673 8 37331794 37331991 198 - 0.175 0.215 0.369