ENSG00000251562

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000508832 ENSG00000251562 HEK293_OSMI2_2hA HEK293_TMG_2hB MALAT1 lncRNA lncRNA 4.619637 2.090743 5.948118 0.3319357 0.1150909 1.503957 0.3946009 0.2138632 0.7951989 0.21386322 0.16185638 1.846728 0.08327083 0.08630000 0.13426667 0.04796667 0.49655839 0.03820047   FALSE
ENST00000534336 ENSG00000251562 HEK293_OSMI2_2hA HEK293_TMG_2hB MALAT1 lncRNA lncRNA 4.619637 2.090743 5.948118 0.3319357 0.1150909 1.503957 1.6783823 0.6457049 1.9374805 0.09701517 0.08585639 1.570490 0.37355833 0.34466667 0.32570000 -0.01896667 1.00000000 0.03820047   FALSE
ENST00000610851 ENSG00000251562 HEK293_OSMI2_2hA HEK293_TMG_2hB MALAT1 lncRNA lncRNA 4.619637 2.090743 5.948118 0.3319357 0.1150909 1.503957 0.1505764 0.2268953 0.0000000 0.16509343 0.00000000 -4.566178 0.03936667 0.09243333 0.00000000 -0.09243333 0.03820047 0.03820047   FALSE
ENST00000618132 ENSG00000251562 HEK293_OSMI2_2hA HEK293_TMG_2hB MALAT1 lncRNA lncRNA 4.619637 2.090743 5.948118 0.3319357 0.1150909 1.503957 0.1896187 0.0000000 0.3930039 0.00000000 0.19856301 5.332722 0.02540000 0.00000000 0.06483333 0.06483333 0.36593286 0.03820047   FALSE
ENST00000618925 ENSG00000251562 HEK293_OSMI2_2hA HEK293_TMG_2hB MALAT1 lncRNA lncRNA 4.619637 2.090743 5.948118 0.3319357 0.1150909 1.503957 0.3311762 0.2762108 0.0000000 0.27621083 0.00000000 -4.839006 0.05597500 0.11686667 0.00000000 -0.11686667 0.62418337 0.03820047   FALSE
ENST00000619449 ENSG00000251562 HEK293_OSMI2_2hA HEK293_TMG_2hB MALAT1 lncRNA lncRNA 4.619637 2.090743 5.948118 0.3319357 0.1150909 1.503957 1.6344578 0.6803744 2.6200701 0.03796319 0.23897022 1.929650 0.36427083 0.34053333 0.43986667 0.09933333 0.38511744 0.03820047   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000251562 E001 0.0000000       11 65497688 65497761 74 +      
ENSG00000251562 E002 0.0000000       11 65497762 65497763 2 +      
ENSG00000251562 E003 0.0000000       11 65497764 65497767 4 +      
ENSG00000251562 E004 0.1472490 0.0424938881 1.0000000000   11 65497768 65497865 98 + 0.077 0.000 -8.339
ENSG00000251562 E005 0.2924217 0.0295563286 0.6588489570   11 65497866 65498681 816 + 0.143 0.000 -12.016
ENSG00000251562 E006 0.1451727 0.0428742044 1.0000000000   11 65498682 65498734 53 + 0.077 0.000 -11.005
ENSG00000251562 E007 0.1515154 0.0421102893 1.0000000000   11 65498735 65498968 234 + 0.077 0.000 -11.008
ENSG00000251562 E008 0.1515154 0.0421102893 1.0000000000   11 65498969 65499041 73 + 0.077 0.000 -11.008
ENSG00000251562 E009 22.4725441 0.0009002000 0.2266690733 0.358421607 11 65499042 65499305 264 + 1.363 1.264 -0.344
ENSG00000251562 E010 14.0774419 0.0166585147 0.0886684309 0.173087494 11 65499306 65499338 33 + 1.194 0.987 -0.749
ENSG00000251562 E011 26.5077617 0.0012444865 0.9539317473 0.975154366 11 65499339 65499462 124 + 1.401 1.405 0.014
ENSG00000251562 E012 36.8401660 0.0006603000 0.3671986325 0.511579975 11 65499463 65499618 156 + 1.524 1.579 0.188
ENSG00000251562 E013 26.2625182 0.0043592783 0.7264945897 0.819488181 11 65499619 65499688 70 + 1.405 1.377 -0.095
ENSG00000251562 E014 67.7962669 0.0087790203 0.4247999402 0.567735496 11 65499689 65500222 534 + 1.816 1.764 -0.174
ENSG00000251562 E015 32.3459094 0.0015223912 0.7901130622 0.865754066 11 65500223 65500398 176 + 1.492 1.474 -0.063
ENSG00000251562 E016 35.7397337 0.0010654861 0.4299708235 0.572598028 11 65500399 65500536 138 + 1.541 1.489 -0.177
ENSG00000251562 E017 53.7228098 0.0012887294 0.0454829179 0.101081629 11 65500537 65500911 375 + 1.731 1.620 -0.377
ENSG00000251562 E018 92.3745702 0.0003798617 0.0699045598 0.143222472 11 65500912 65501847 936 + 1.956 1.883 -0.245
ENSG00000251562 E019 22.4732220 0.0045328937 0.1859220268 0.308646682 11 65501848 65501959 112 + 1.366 1.251 -0.402
ENSG00000251562 E020 45.5383544 0.0005336054 0.5989222437 0.720424787 11 65501960 65502393 434 + 1.639 1.609 -0.102
ENSG00000251562 E021 12.5509430 0.0036686269 0.1889277492 0.312408462 11 65502394 65502636 243 + 1.047 1.180 0.477
ENSG00000251562 E022 23.4511452 0.0053515630 0.6190892108 0.736578096 11 65502637 65502728 92 + 1.344 1.385 0.144
ENSG00000251562 E023 40.3589085 0.0005742530 0.9708779054 0.985817447 11 65502729 65502913 185 + 1.583 1.585 0.006
ENSG00000251562 E024 32.4715510 0.0006523483 0.7192572101 0.814141660 11 65502914 65503008 95 + 1.481 1.504 0.080
ENSG00000251562 E025 36.2201219 0.0005963708 0.0731072071 0.148496173 11 65503009 65503120 112 + 1.500 1.609 0.371
ENSG00000251562 E026 48.4557380 0.0038955901 0.5840218977 0.708022093 11 65503121 65503678 558 + 1.647 1.679 0.108
ENSG00000251562 E027 10.0728054 0.0431792982 0.5280441567 0.660955356 11 65503679 65503704 26 + 0.974 1.060 0.319
ENSG00000251562 E028 9.4126093 0.0137959922 0.8927812095 0.935476095 11 65503705 65503728 24 + 0.973 0.987 0.053
ENSG00000251562 E029 18.2250072 0.0017458735 0.6936212092 0.794642436 11 65503729 65503799 71 + 1.231 1.264 0.119
ENSG00000251562 E030 20.5510763 0.0167519263 0.3947575668 0.538584121 11 65503800 65503905 106 + 1.265 1.350 0.298
ENSG00000251562 E031 15.0113099 0.0065821639 0.1657685584 0.282705641 11 65503906 65504004 99 + 1.117 1.252 0.481
ENSG00000251562 E032 10.2079702 0.0347480284 0.2139860813 0.343239784 11 65504005 65504132 128 + 0.955 1.116 0.589
ENSG00000251562 E033 6.4341927 0.0025498376 0.9539283362 0.975154366 11 65504133 65504206 74 + 0.836 0.843 0.028
ENSG00000251562 E034 9.6104322 0.0019887319 0.5943897481 0.716629620 11 65504207 65504325 119 + 0.973 1.032 0.219
ENSG00000251562 E035 7.5535270 0.0029570291 0.6753218335 0.780636256 11 65504326 65504358 33 + 0.883 0.934 0.196
ENSG00000251562 E036 16.4148048 0.0011710216 0.5406385728 0.671745341 11 65504359 65504495 137 + 1.183 1.238 0.193
ENSG00000251562 E037 12.0694169 0.0016482770 0.2876494196 0.428162008 11 65504496 65504518 23 + 1.040 1.147 0.389
ENSG00000251562 E038 14.5854709 0.0011910354 0.1101453762 0.205745524 11 65504519 65504595 77 + 1.104 1.251 0.523
ENSG00000251562 E039 10.3792390 0.0304383149 0.1088762315 0.203883435 11 65504596 65504657 62 + 0.935 1.152 0.794
ENSG00000251562 E040 15.3909725 0.0050085171 0.8471906290 0.905085002 11 65504658 65504819 162 + 1.183 1.164 -0.070
ENSG00000251562 E041 10.6204642 0.0341823963 0.7780729388 0.857226244 11 65504820 65504837 18 + 1.047 1.007 -0.149
ENSG00000251562 E042 18.3969523 0.0010396124 0.4697139920 0.608933627 11 65504838 65505019 182 + 1.273 1.209 -0.225
ENSG00000251562 E043 16.1446872 0.0020446322 0.1447299718 0.254465512 11 65505020 65505203 184 + 1.235 1.094 -0.506
ENSG00000251562 E044 6.7034215 0.0034119061 0.4088625366 0.552476665 11 65505204 65505206 3 + 0.883 0.770 -0.441
ENSG00000251562 E045 11.1935016 0.0096891085 0.6122368926 0.731212837 11 65505207 65505278 72 + 1.069 1.010 -0.216
ENSG00000251562 E046 16.8645725 0.0012965134 0.1995506327 0.325665703 11 65505279 65505503 225 + 1.250 1.130 -0.427
ENSG00000251562 E047 9.7546745 0.0017295750 0.8617875265 0.914895273 11 65505504 65505590 87 + 0.990 1.010 0.071
ENSG00000251562 E048 9.9900674 0.0017682340 0.4037865750 0.547567021 11 65505591 65505662 72 + 1.032 0.934 -0.361
ENSG00000251562 E049 24.9636855 0.0008008056 0.3269145843 0.470365210 11 65505663 65506116 454 + 1.352 1.424 0.249
ENSG00000251562 E050 8.5647989 0.0021083432 0.1362400124 0.242806603 11 65506117 65506259 143 + 0.883 1.054 0.637
ENSG00000251562 E051 7.2132199 0.0119244220 0.0325101741 0.076825603 11 65506260 65506385 126 + 0.784 1.053 1.021
ENSG00000251562 E052 3.2911571 0.0064125132 0.0004000108 0.001774436 11 65506386 65506516 131 + 0.374 0.906 2.367