ENSG00000251396

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000476425 ENSG00000251396 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5984962 0.8708458 0.5575443 0.1082378 0.1205789 -0.6341564 0.182467095 0.043635947 0.25333509 0.022427532 0.087648204 2.295628 0.337700000 0.05553333 0.44140000 0.38586667 0.005512483 0.005512483   FALSE
ENST00000530725 ENSG00000251396 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5984962 0.8708458 0.5575443 0.1082378 0.1205789 -0.6341564 0.055455091 0.074349366 0.01647255 0.026094965 0.008238548 -1.671880 0.106941667 0.08010000 0.02916667 -0.05093333 0.478212571 0.005512483   FALSE
ENST00000531654 ENSG00000251396 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5984962 0.8708458 0.5575443 0.1082378 0.1205789 -0.6341564 0.008030632 0.064245056 0.00000000 0.064245056 0.000000000 -2.892295 0.007729167 0.06183333 0.00000000 -0.06183333 0.812050187 0.005512483 TRUE FALSE
ENST00000532232 ENSG00000251396 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5984962 0.8708458 0.5575443 0.1082378 0.1205789 -0.6341564 0.239924442 0.587808277 0.12729197 0.013502247 0.072454019 -2.122436 0.330920833 0.69953333 0.20526667 -0.49426667 0.051136912 0.005512483   FALSE
ENST00000656656 ENSG00000251396 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5984962 0.8708458 0.5575443 0.1082378 0.1205789 -0.6341564 0.028720103 0.000000000 0.02331391 0.000000000 0.023313912 1.736125 0.051395833 0.00000000 0.05303333 0.05303333 0.715436905 0.005512483   FALSE
ENST00000664011 ENSG00000251396 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5984962 0.8708458 0.5575443 0.1082378 0.1205789 -0.6341564 0.019521008 0.005979736 0.05061209 0.005979736 0.015954985 1.923362 0.039908333 0.00660000 0.09936667 0.09276667 0.163593672 0.005512483 FALSE FALSE
ENST00000670404 ENSG00000251396 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.5984962 0.8708458 0.5575443 0.1082378 0.1205789 -0.6341564 0.032875993 0.024525767 0.07704226 0.013608776 0.013312890 1.334042 0.067545833 0.02486667 0.14993333 0.12506667 0.099895995 0.005512483   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000251396 E001 0.1482932 0.044129367 0.434976329   8 60289928 60290775 848 - 0.000 0.131 10.922
ENSG00000251396 E002 0.0000000       8 60292169 60292258 90 -      
ENSG00000251396 E003 0.0000000       8 60293450 60293583 134 -      
ENSG00000251396 E004 0.0000000       8 60299337 60299413 77 -      
ENSG00000251396 E005 0.3697384 0.027442404 0.175213390 0.29495957 8 60322513 60322658 146 - 0.000 0.232 13.786
ENSG00000251396 E006 0.4428904 0.180429163 0.209182402 0.33753793 8 60325102 60325168 67 - 0.000 0.236 13.755
ENSG00000251396 E007 1.6232010 0.009494914 0.004520399 0.01460093 8 60358633 60361623 2991 - 0.602 0.131 -3.086
ENSG00000251396 E008 1.3275570 0.012367745 0.104508976 0.19736938 8 60363208 60363300 93 - 0.491 0.232 -1.572
ENSG00000251396 E009 0.8115992 0.016247049 0.716835439 0.81238392 8 60384588 60384665 78 - 0.279 0.232 -0.348
ENSG00000251396 E010 0.9598924 0.014529650 0.934339406 0.96259529 8 60385207 60385406 200 - 0.279 0.314 0.236
ENSG00000251396 E011 1.9845057 0.010692141 0.289837433 0.43057646 8 60402228 60403211 984 - 0.531 0.383 -0.760
ENSG00000251396 E012 0.1472490 0.071174269 0.576475128   8 60403212 60403352 141 - 0.114 0.000 -12.975
ENSG00000251396 E013 0.1472490 0.071174269 0.576475128   8 60403353 60403492 140 - 0.114 0.000 -12.975
ENSG00000251396 E014 1.6316200 0.009132097 0.004424045 0.01432932 8 60403493 60404678 1186 - 0.602 0.131 -3.086
ENSG00000251396 E015 2.8378215 0.062194139 0.337860388 0.48173827 8 60404679 60405249 571 - 0.633 0.498 -0.617
ENSG00000251396 E016 0.1451727 0.051432779 0.575949634   8 60408355 60408497 143 - 0.114 0.000 -12.978
ENSG00000251396 E017 0.0000000       8 60412340 60412493 154 -      
ENSG00000251396 E018 0.0000000       8 60412494 60412593 100 -      
ENSG00000251396 E019 0.2214452 0.040256607 0.433617711   8 60412594 60412620 27 - 0.000 0.132 12.958
ENSG00000251396 E020 0.2214452 0.040256607 0.433617711   8 60412621 60412783 163 - 0.000 0.132 12.958
ENSG00000251396 E021 0.2965864 0.080502982 0.189128106   8 60413010 60413196 187 - 0.000 0.230 13.754
ENSG00000251396 E022 0.8126288 0.026503770 0.031303593 0.07448812 8 60413197 60413470 274 - 0.000 0.384 14.606
ENSG00000251396 E023 0.0000000       8 60413556 60413930 375 -      
ENSG00000251396 E024 2.6698613 0.007243862 0.100696276 0.19152451 8 60468072 60468192 121 - 0.663 0.442 -1.027
ENSG00000251396 E025 2.5808095 0.007026506 0.009124286 0.02659377 8 60468863 60469116 254 - 0.279 0.719 2.237
ENSG00000251396 E026 4.9799052 0.004059470 0.163428438 0.27962205 8 60508647 60508762 116 - 0.662 0.867 0.822
ENSG00000251396 E027 4.2510350 0.004557949 0.034271273 0.08028031 8 60516598 60516815 218 - 0.531 0.845 1.324