ENSG00000251365

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000508881 ENSG00000251365 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02236 lncRNA lncRNA 0.388886 0.3463658 0.7525656 0.1748362 0.1586733 1.097502 0.05076287 0.03736062 0.10580995 0.03736062 0.06138757 1.289999 0.09454583 0.05376667 0.12410000 0.07033333 0.87747896 0.04934562   FALSE
ENST00000648399 ENSG00000251365 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02236 lncRNA lncRNA 0.388886 0.3463658 0.7525656 0.1748362 0.1586733 1.097502 0.09131165 0.03564450 0.24511517 0.01785583 0.04963230 2.482636 0.25285000 0.14926667 0.33083333 0.18156667 0.16507570 0.04934562   FALSE
ENST00000660855 ENSG00000251365 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02236 lncRNA lncRNA 0.388886 0.3463658 0.7525656 0.1748362 0.1586733 1.097502 0.06521203 0.12885454 0.07473320 0.06121525 0.00769527 -0.712575 0.16449583 0.38216667 0.11103333 -0.27113333 0.04934562 0.04934562   FALSE
ENST00000688820 ENSG00000251365 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02236 lncRNA lncRNA 0.388886 0.3463658 0.7525656 0.1748362 0.1586733 1.097502 0.03517137 0.01242807 0.18014952 0.01242807 0.10080102 3.083757 0.08853750 0.08386667 0.19626667 0.11240000 0.56994587 0.04934562   FALSE
ENST00000690700 ENSG00000251365 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02236 lncRNA lncRNA 0.388886 0.3463658 0.7525656 0.1748362 0.1586733 1.097502 0.09774771 0.12155806 0.03616732 0.08324790 0.03616732 -1.510756 0.27809167 0.27730000 0.07870000 -0.19860000 0.34161405 0.04934562   FALSE
ENST00000691419 ENSG00000251365 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC02236 lncRNA lncRNA 0.388886 0.3463658 0.7525656 0.1748362 0.1586733 1.097502 0.02676549 0.00000000 0.04769019 0.00000000 0.02387034 2.528326 0.07682083 0.00000000 0.08136667 0.08136667 0.61034082 0.04934562   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000251365 E001 0.0000000       5 6765891 6765893 3 +      
ENSG00000251365 E002 0.0000000       5 6765894 6765914 21 +      
ENSG00000251365 E003 0.0000000       5 6765915 6765928 14 +      
ENSG00000251365 E004 0.0000000       5 6765929 6765943 15 +      
ENSG00000251365 E005 0.0000000       5 6765944 6765981 38 +      
ENSG00000251365 E006 0.0000000       5 6768275 6768424 150 +      
ENSG00000251365 E007 0.0000000       5 6771599 6771953 355 +      
ENSG00000251365 E008 2.2727603 0.584835831 0.9023768511 0.941820075 5 6775559 6775817 259 + 0.463 0.540 0.373
ENSG00000251365 E009 2.6101473 0.008094999 0.9010157142 0.940855582 5 6775818 6776029 212 + 0.561 0.506 -0.259
ENSG00000251365 E010 0.2998086 0.036706716 0.5162788399   5 6776030 6776669 640 + 0.094 0.158 0.873
ENSG00000251365 E011 0.9953799 0.013479921 0.2921006923 0.433040988 5 6777050 6777081 32 + 0.236 0.366 0.877
ENSG00000251365 E012 0.7792333 0.020730008 0.6321757561 0.747080953 5 6777082 6777158 77 + 0.292 0.159 -1.124
ENSG00000251365 E013 1.7026071 0.024322568 0.8630131666 0.915657671 5 6777334 6777509 176 + 0.466 0.366 -0.541
ENSG00000251365 E014 0.1472490 0.049360811 1.0000000000   5 6782128 6782393 266 + 0.093 0.000 -10.777
ENSG00000251365 E015 2.2508991 0.008938750 0.0007066359 0.002922416 5 6786106 6786687 582 + 0.236 0.697 2.465
ENSG00000251365 E016 0.3332198 0.033358348 0.5185530320   5 6791468 6791709 242 + 0.094 0.159 0.876
ENSG00000251365 E017 0.8062886 0.018161473 0.6283077951 0.743869531 5 6795880 6796345 466 + 0.292 0.159 -1.122
ENSG00000251365 E018 0.1515154 0.049363342 1.0000000000   5 6826560 6826642 83 + 0.094 0.000 -10.778
ENSG00000251365 E019 0.6017953 0.241748169 0.2657315756 0.403815393 5 6826643 6826728 86 + 0.293 0.000 -12.783
ENSG00000251365 E020 0.1472490 0.049360811 1.0000000000   5 6826729 6826851 123 + 0.093 0.000 -10.777
ENSG00000251365 E021 0.2987644 0.032293132 0.5771347038   5 6826852 6827165 314 + 0.170 0.000 -11.778
ENSG00000251365 E022 0.8857980 0.016034546 0.0768780135 0.154500610 5 6827166 6827822 657 + 0.388 0.000 -13.362
ENSG00000251365 E023 0.5975289 0.024441170 0.1979897599 0.323706027 5 6827823 6828314 492 + 0.293 0.000 -12.778
ENSG00000251365 E024 0.1472490 0.049360811 1.0000000000   5 6831556 6831614 59 + 0.093 0.000 -10.777
ENSG00000251365 E025 0.7665478 0.019648825 0.6338057852 0.748414350 5 6832222 6832298 77 + 0.292 0.159 -1.123
ENSG00000251365 E026 1.5834456 0.009214205 0.4621316278 0.602020619 5 6832991 6833120 130 + 0.466 0.275 -1.123