ENSG00000250938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000508362 ENSG00000250938 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.1976829 0.184481 0.2029382 0.09279784 0.02331614 0.1308057 0.05729035 0.06713614 0.00000000 0.03363457 0.00000000 -2.9474070 0.31339524 0.36625 0.00000000 -0.3662500000 0.05534292 0.01393424   FALSE
ENST00000511064 ENSG00000250938 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.1976829 0.184481 0.2029382 0.09279784 0.02331614 0.1308057 0.04569466 0.00000000 0.02790490 0.00000000 0.02790490 1.9223843 0.16836190 0.00000 0.16300000 0.1630000000 0.99396070 0.01393424   FALSE
ENST00000653046 ENSG00000250938 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.1976829 0.184481 0.2029382 0.09279784 0.02331614 0.1308057 0.01930235 0.01587784 0.02266946 0.01587784 0.02266946 0.3362257 0.13710952 0.09190 0.09126667 -0.0006333333 0.95536215 0.01393424   FALSE
ENST00000686551 ENSG00000250938 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.1976829 0.184481 0.2029382 0.09279784 0.02331614 0.1308057 0.02368942 0.00000000 0.05787870 0.00000000 0.02894188 2.7629590 0.13348571 0.00000 0.28596667 0.2859666667 0.63483543 0.01393424   FALSE
ENST00000691548 ENSG00000250938 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.1976829 0.184481 0.2029382 0.09279784 0.02331614 0.1308057 0.03989548 0.10146700 0.00000000 0.05701689 0.00000000 -3.4785447 0.18197619 0.54185 0.00000000 -0.5418500000 0.01393424 0.01393424   FALSE
ENST00000693125 ENSG00000250938 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 0.1976829 0.184481 0.2029382 0.09279784 0.02331614 0.1308057 0.01181064 0.00000000 0.09448514 0.00000000 0.05462497 3.3852258 0.06568571 0.00000 0.45980000 0.4598000000 0.76192722 0.01393424   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000250938 E001 0.3299976 0.03117564 0.27685764   4 120066944 120066954 11 + 0.000 0.204 10.743
ENSG00000250938 E002 0.3299976 0.03117564 0.27685764   4 120066955 120066957 3 + 0.000 0.204 12.868
ENSG00000250938 E003 0.3299976 0.03117564 0.27685764   4 120066958 120066961 4 + 0.000 0.204 12.868
ENSG00000250938 E004 0.4751703 0.02332096 0.70454514 0.80307795 4 120066962 120066969 8 + 0.131 0.204 0.762
ENSG00000250938 E005 1.4349609 0.03264919 0.13030421 0.23458591 4 120066970 120067001 32 + 0.232 0.489 1.562
ENSG00000250938 E006 1.1707416 0.01407799 0.91074956 0.94728655 4 120067511 120067601 91 + 0.314 0.342 0.180
ENSG00000250938 E007 0.3299976 0.03117564 0.27685764   4 120083285 120083331 47 + 0.000 0.204 12.868
ENSG00000250938 E008 0.0000000       4 120083332 120085579 2248 +      
ENSG00000250938 E009 0.3332198 0.04019066 0.86237826   4 120150543 120150621 79 + 0.131 0.114 -0.236
ENSG00000250938 E010 0.0000000       4 120150622 120151118 497 +      
ENSG00000250938 E011 0.1472490 0.82753172 0.47987131   4 120165490 120165970 481 + 0.131 0.000 -12.536
ENSG00000250938 E012 0.0000000       4 120262185 120262360 176 +      
ENSG00000250938 E013 0.1451727 0.05282869 0.41109983   4 120328533 120328586 54 + 0.131 0.000 -12.644
ENSG00000250938 E014 0.9202533 0.01887000 0.04343755 0.09735947 4 120335638 120335731 94 + 0.442 0.114 -2.558
ENSG00000250938 E015 0.2924217 0.03972148 0.15703948   4 120367658 120367974 317 + 0.232 0.000 -13.377
ENSG00000250938 E016 0.4720498 0.02701585 0.46911368 0.60840935 4 120393500 120393554 55 + 0.232 0.114 -1.236
ENSG00000250938 E017 0.1817044 0.07744925 0.59698748   4 120393555 120393773 219 + 0.000 0.114 12.071
ENSG00000250938 E018 0.0000000       4 120416550 120416766 217 +      
ENSG00000250938 E019 0.2966881 0.03832564 0.15741464   4 120419299 120419576 278 + 0.232 0.000 -13.378
ENSG00000250938 E020 0.2934659 0.03408637 0.87661341   4 120564311 120564789 479 + 0.131 0.114 -0.239