ENSG00000250903

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000456943 ENSG00000250903 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS-DT lncRNA lncRNA 1.553394 1.350229 2.4987 0.1647456 0.1339185 0.8830902 0.04855944 0.11942236 0.01403941 0.03481801 0.01403941 -2.4286135 0.04258333 0.09396667 0.005133333 -0.08883333 0.02362727 0.02362727 TRUE FALSE
ENST00000525811 ENSG00000250903 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS-DT lncRNA lncRNA 1.553394 1.350229 2.4987 0.1647456 0.1339185 0.8830902 0.14994935 0.03695527 0.00000000 0.03695527 0.00000000 -2.2312869 0.08603750 0.02203333 0.000000000 -0.02203333 0.47980230 0.02362727   FALSE
ENST00000529893 ENSG00000250903 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS-DT lncRNA lncRNA 1.553394 1.350229 2.4987 0.1647456 0.1339185 0.8830902 0.05703674 0.00000000 0.16766587 0.00000000 0.09197691 4.1510947 0.02858333 0.00000000 0.065766667 0.06576667 0.30202352 0.02362727   FALSE
ENST00000534160 ENSG00000250903 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS-DT lncRNA lncRNA 1.553394 1.350229 2.4987 0.1647456 0.1339185 0.8830902 0.09836718 0.08027355 0.17928241 0.04216637 0.05270649 1.0681650 0.06065000 0.06076667 0.070066667 0.00930000 0.88478957 0.02362727 FALSE TRUE
ENST00000663428 ENSG00000250903 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS-DT lncRNA lncRNA 1.553394 1.350229 2.4987 0.1647456 0.1339185 0.8830902 0.08975338 0.08703256 0.16024467 0.05718420 0.04739044 0.8110688 0.05874583 0.07443333 0.062566667 -0.01186667 0.94772702 0.02362727   FALSE
ENST00000691004 ENSG00000250903 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS-DT lncRNA lncRNA 1.553394 1.350229 2.4987 0.1647456 0.1339185 0.8830902 0.18162899 0.43016829 0.14074032 0.05917891 0.14074032 -1.5459899 0.14436667 0.32256667 0.056833333 -0.26573333 0.09285821 0.02362727   FALSE
MSTRG.27524.19 ENSG00000250903 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS-DT lncRNA   1.553394 1.350229 2.4987 0.1647456 0.1339185 0.8830902 0.41157912 0.28823262 1.20309739 0.14421679 0.16800390 2.0241854 0.23974167 0.20470000 0.479833333 0.27513333 0.30184282 0.02362727   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000250903 E001 0.0000000       6 2245718 2245731 14 +      
ENSG00000250903 E002 0.1482932 0.040720292 0.36246319   6 2245732 2245735 4 + 0.000 0.139 11.216
ENSG00000250903 E003 0.1482932 0.040720292 0.36246319   6 2245736 2245745 10 + 0.000 0.139 13.599
ENSG00000250903 E004 0.1482932 0.040720292 0.36246319   6 2245746 2245753 8 + 0.000 0.139 13.599
ENSG00000250903 E005 0.1482932 0.040720292 0.36246319   6 2245754 2245758 5 + 0.000 0.139 13.599
ENSG00000250903 E006 0.1482932 0.040720292 0.36246319   6 2245759 2245761 3 + 0.000 0.139 13.599
ENSG00000250903 E007 0.2998086 0.028298859 0.82260577   6 2245762 2245764 3 + 0.107 0.139 0.436
ENSG00000250903 E008 0.5996172 0.232558965 0.81546707 0.88316587 6 2245765 2245767 3 + 0.193 0.241 0.400
ENSG00000250903 E009 1.9314261 0.009885107 0.96491243 0.98189700 6 2245768 2245772 5 + 0.471 0.461 -0.048
ENSG00000250903 E010 3.4667223 0.005584215 0.62061866 0.73773988 6 2245773 2245776 4 + 0.610 0.680 0.302
ENSG00000250903 E011 4.5049781 0.004635210 0.66020642 0.76890422 6 2245777 2245780 4 + 0.715 0.773 0.231
ENSG00000250903 E012 6.5376819 0.045013785 0.49897217 0.63534351 6 2245781 2245784 4 + 0.837 0.914 0.295
ENSG00000250903 E013 13.7277380 0.001393375 0.53293660 0.66521048 6 2245785 2245840 56 + 1.199 1.142 -0.203
ENSG00000250903 E014 13.8728090 0.001387990 0.78255153 0.86039185 6 2245841 2245841 1 + 1.191 1.165 -0.093
ENSG00000250903 E015 14.3919745 0.001245398 0.58531096 0.70902676 6 2245842 2245852 11 + 1.214 1.165 -0.174
ENSG00000250903 E016 12.4356580 0.001441293 0.30254241 0.44442185 6 2245853 2245854 2 + 1.175 1.079 -0.348
ENSG00000250903 E017 14.5058003 0.001245291 0.28437969 0.42461955 6 2245855 2245894 40 + 1.236 1.142 -0.333
ENSG00000250903 E018 13.5867790 0.001394477 0.50720330 0.64280220 6 2245895 2245930 36 + 1.191 1.130 -0.218
ENSG00000250903 E019 0.0000000       6 2248835 2248836 2 +      
ENSG00000250903 E020 13.2577344 0.001436007 0.60254001 0.72349942 6 2248837 2248871 35 + 1.133 1.177 0.156
ENSG00000250903 E021 11.9634908 0.001500753 0.76983211 0.85139075 6 2248872 2248895 24 + 1.105 1.130 0.090
ENSG00000250903 E022 10.3962996 0.001912133 0.02507442 0.06202860 6 2248896 2248926 31 + 0.946 1.165 0.800
ENSG00000250903 E023 9.4354543 0.005755130 0.61727259 0.73512526 6 2263601 2263684 84 + 0.998 1.050 0.192
ENSG00000250903 E024 0.2944980 0.526744160 0.44499587   6 2263685 2266348 2664 + 0.193 0.000 -14.122
ENSG00000250903 E025 3.8049249 0.004282018 0.25176803 0.38803672 6 2269698 2269799 102 + 0.610 0.772 0.678
ENSG00000250903 E026 0.5953508 0.022233418 0.76882635 0.85060173 6 2269800 2270013 214 + 0.193 0.244 0.434
ENSG00000250903 E027 4.6520962 0.012805651 0.03699464 0.08546563 6 2271816 2273417 1602 + 0.579 0.873 1.207
ENSG00000250903 E028 0.6663248 0.025935677 0.01845558 0.04813196 6 2283499 2283516 18 + 0.000 0.400 15.450
ENSG00000250903 E029 2.3668555 0.006644560 0.73868995 0.82850391 6 2283517 2283763 247 + 0.510 0.562 0.244
ENSG00000250903 E030 0.1817044 0.041230852 0.35948908   6 2283764 2283774 11 + 0.000 0.140 13.602
ENSG00000250903 E031 0.4482035 0.023480411 0.14792348 0.25885282 6 2306200 2306292 93 + 0.265 0.000 -14.718
ENSG00000250903 E032 1.1427281 0.224003382 0.29490104 0.43600640 6 2306293 2306526 234 + 0.193 0.411 1.497
ENSG00000250903 E033 1.5352857 0.127322067 0.21693427 0.34670942 6 2306527 2307493 967 + 0.509 0.246 -1.553
ENSG00000250903 E034 0.3332198 0.029368009 0.81770317   6 2318864 2319008 145 + 0.107 0.140 0.439
ENSG00000250903 E035 1.6544326 0.021160850 0.89588612 0.93746689 6 2329283 2329332 50 + 0.428 0.401 -0.143
ENSG00000250903 E036 0.7708142 0.015512078 0.29918011 0.44067582 6 2329333 2329404 72 + 0.326 0.140 -1.561
ENSG00000250903 E037 2.1380975 0.040954525 0.44145510 0.58309636 6 2352339 2352702 364 + 0.546 0.402 -0.722
ENSG00000250903 E038 0.3299976 0.027442404 0.12920303   6 2360544 2360630 87 + 0.000 0.245 14.541
ENSG00000250903 E039 0.2214452 0.052217364 0.35865826   6 2360631 2362108 1478 + 0.000 0.140 13.600
ENSG00000250903 E040 0.0000000       6 2366944 2367315 372 +      
ENSG00000250903 E041 0.7437457 0.015621318 0.29721935 0.43852646 6 2382854 2383014 161 + 0.326 0.139 -1.563
ENSG00000250903 E042 0.2998086 0.028298859 0.82260577   6 2391546 2396571 5026 + 0.107 0.139 0.436
ENSG00000250903 E043 0.0000000       6 2396572 2397220 649 +      
ENSG00000250903 E044 2.7981969 0.005867024 0.02097489 0.05353637 6 2397221 2397543 323 + 0.715 0.330 -1.882
ENSG00000250903 E045 1.0309706 0.013132811 0.01136067 0.03202888 6 2397544 2397626 83 + 0.471 0.000 -15.789
ENSG00000250903 E046 0.5911862 0.017868185 0.07385428 0.14967342 6 2397627 2398576 950 + 0.326 0.000 -15.085
ENSG00000250903 E047 6.1257986 0.002869353 0.63561568 0.74986967 6 2398577 2398778 202 + 0.837 0.893 0.215
ENSG00000250903 E048 2.0723324 0.007101145 0.77859230 0.85753971 6 2398866 2398882 17 + 0.510 0.461 -0.240
ENSG00000250903 E049 3.8530993 0.024720731 0.65325239 0.76377469 6 2398883 2399037 155 + 0.666 0.740 0.308
ENSG00000250903 E050 2.4733195 0.006451638 0.69436422 0.79520994 6 2399038 2399905 868 + 0.579 0.515 -0.300
ENSG00000250903 E051 0.3030308 0.297745881 0.39238203   6 2412487 2412779 293 + 0.193 0.000 -14.160
ENSG00000250903 E052 7.7477333 0.002410563 0.03758578 0.08655792 6 2412780 2413591 812 + 0.819 1.050 0.871
ENSG00000250903 E053 0.1515154 0.042651579 0.66031899   6 2452382 2452410 29 + 0.107 0.000 -13.269
ENSG00000250903 E054 0.1515154 0.042651579 0.66031899   6 2452411 2452560 150 + 0.107 0.000 -13.269
ENSG00000250903 E055 0.4417471 0.858164353 0.45189196 0.59280663 6 2453964 2454021 58 + 0.264 0.000 -14.576
ENSG00000250903 E056 1.0382438 0.013256456 0.11170010 0.20805476 6 2469128 2471134 2007 + 0.428 0.139 -2.148
ENSG00000250903 E057 3.8685145 0.005949382 0.88111623 0.92778796 6 2480834 2481169 336 + 0.691 0.713 0.088
ENSG00000250903 E058 4.4912470 0.005790206 0.53718382 0.66881261 6 2481170 2481972 803 + 0.691 0.773 0.333
ENSG00000250903 E059 0.8010032 0.177117145 0.92949277 0.95960598 6 2481973 2481986 14 + 0.264 0.246 -0.138
ENSG00000250903 E060 9.3849862 0.001972113 0.08882264 0.17331530 6 2481987 2485954 3968 + 1.096 0.914 -0.672
ENSG00000250903 E061 0.9986021 0.013215726 0.65964030 0.76841692 6 2488679 2489567 889 + 0.326 0.245 -0.560
ENSG00000250903 E062 0.0000000       6 2524338 2525976 1639 +