ENSG00000250722

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000507920 ENSG00000250722 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOP protein_coding protein_coding 4.245592 3.071677 8.612157 0.7782781 0.8108928 1.484333 0.2880692 0.000000 0.9067531 0.0000000 0.9067531 6.518461 0.0517000 0.0000 0.08866667 0.08866667 9.939465e-01 5.905767e-09 FALSE FALSE
ENST00000513303 ENSG00000250722 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOP protein_coding processed_transcript 4.245592 3.071677 8.612157 0.7782781 0.8108928 1.484333 0.6095646 1.567452 0.0000000 0.6373682 0.0000000 -7.301452 0.2352667 0.4546 0.00000000 -0.45460000 5.905767e-09 5.905767e-09   FALSE
ENST00000514985 ENSG00000250722 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOP protein_coding protein_coding 4.245592 3.071677 8.612157 0.7782781 0.8108928 1.484333 3.0853047 1.314604 7.2898059 0.3397824 0.2859626 2.462298 0.6436333 0.4882 0.86316667 0.37496667 1.814814e-01 5.905767e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000250722 E001 0.5879639 0.0206935821 8.221053e-01 8.878124e-01 5 42799880 42799882 3 - 0.165 0.228 0.581
ENSG00000250722 E002 17.2955121 0.0012353691 2.816851e-06 2.121845e-05 5 42799883 42800111 229 - 1.053 1.496 1.559
ENSG00000250722 E003 9.9495761 0.0340657858 6.349338e-03 1.953175e-02 5 42800112 42800130 19 - 0.835 1.270 1.594
ENSG00000250722 E004 68.5367820 0.0054282066 5.187101e-01 6.529266e-01 5 42800131 42800818 688 - 1.738 1.825 0.294
ENSG00000250722 E005 33.7106637 0.0006153031 7.905968e-03 2.354231e-02 5 42800819 42800927 109 - 1.486 1.336 -0.519
ENSG00000250722 E006 22.4433101 0.0009035536 5.240937e-02 1.134469e-01 5 42800928 42800933 6 - 1.315 1.190 -0.441
ENSG00000250722 E007 47.2756746 0.0005151179 2.334989e-04 1.106196e-03 5 42800934 42801104 171 - 1.634 1.445 -0.646
ENSG00000250722 E008 34.2182100 0.0035212412 3.552108e-03 1.187528e-02 5 42801105 42801199 95 - 1.497 1.308 -0.655
ENSG00000250722 E009 27.0665980 0.0009320229 5.039621e-04 2.174957e-03 5 42801200 42801237 38 - 1.410 1.149 -0.916
ENSG00000250722 E010 37.7307874 0.0005472853 2.964277e-03 1.015705e-02 5 42801238 42801331 94 - 1.537 1.376 -0.557
ENSG00000250722 E011 22.4361021 0.0153594856 3.105422e-02 7.402023e-02 5 42804656 42804668 13 - 1.325 1.145 -0.636
ENSG00000250722 E012 36.6458673 0.0006521968 2.305747e-03 8.169839e-03 5 42804669 42804773 105 - 1.524 1.350 -0.600
ENSG00000250722 E013 2.3095861 0.0391111062 5.825916e-01 7.069305e-01 5 42804774 42806582 1809 - 0.430 0.574 0.700
ENSG00000250722 E014 0.6203429 0.0538318892 1.902016e-01 3.140277e-01 5 42806583 42806895 313 - 0.116 0.376 2.165
ENSG00000250722 E015 18.1836194 0.0010235895 1.333141e-02 3.669324e-02 5 42806896 42806901 6 - 1.237 1.028 -0.753
ENSG00000250722 E016 44.5950214 0.0005324983 2.566203e-01 3.936036e-01 5 42806902 42807108 207 - 1.549 1.667 0.404
ENSG00000250722 E017 0.0000000       5 42807109 42807298 190 -      
ENSG00000250722 E018 0.1451727 0.0455304596 1.000000e+00   5 42807604 42807689 86 - 0.062 0.000 -8.919
ENSG00000250722 E019 0.1451727 0.0455304596 1.000000e+00   5 42807818 42808150 333 - 0.062 0.000 -8.919
ENSG00000250722 E020 62.0999875 0.0315171439 3.182645e-04 1.453925e-03 5 42808151 42808366 216 - 1.617 1.968 1.185
ENSG00000250722 E021 0.0000000       5 42808367 42808405 39 -      
ENSG00000250722 E022 0.0000000       5 42809760 42809788 29 -      
ENSG00000250722 E023 0.1472490 0.0465802900 1.000000e+00   5 42810691 42810778 88 - 0.062 0.000 -8.919
ENSG00000250722 E024 38.6535396 0.0183157747 4.290015e-04 1.886123e-03 5 42811836 42811893 58 - 1.426 1.753 1.117
ENSG00000250722 E025 0.0000000       5 42825441 42825896 456 -      
ENSG00000250722 E026 0.0000000       5 42887291 42887392 102 -