ENSG00000250682

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000505527 ENSG00000250682 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00491 lncRNA lncRNA 1.534453 0.9654337 1.883461 0.02397794 0.09513213 0.9569097 0.10362437 0.00000000 0.14731232 0.00000000 0.14731232 3.9755597 0.05217500 0.00000000 0.07436667 0.07436667 0.914057802 0.001524323   FALSE
ENST00000510145 ENSG00000250682 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00491 lncRNA lncRNA 1.534453 0.9654337 1.883461 0.02397794 0.09513213 0.9569097 0.15301773 0.20578782 0.00000000 0.20578782 0.00000000 -4.4315415 0.11512083 0.20726667 0.00000000 -0.20726667 0.715632388 0.001524323   FALSE
ENST00000513815 ENSG00000250682 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00491 lncRNA lncRNA 1.534453 0.9654337 1.883461 0.02397794 0.09513213 0.9569097 0.11440004 0.00000000 0.25810452 0.00000000 0.05108534 4.7447236 0.06174167 0.00000000 0.13643333 0.13643333 0.001524323 0.001524323   FALSE
ENST00000660106 ENSG00000250682 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00491 lncRNA lncRNA 1.534453 0.9654337 1.883461 0.02397794 0.09513213 0.9569097 0.22732353 0.05017466 0.19111573 0.03214760 0.01846066 1.7407980 0.15036667 0.05166667 0.10133333 0.04966667 0.523687458 0.001524323   FALSE
ENST00000662437 ENSG00000250682 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00491 lncRNA lncRNA 1.534453 0.9654337 1.883461 0.02397794 0.09513213 0.9569097 0.73033553 0.52355543 1.13124129 0.18479248 0.03814647 1.0968938 0.49095833 0.54856667 0.60173333 0.05316667 0.977781152 0.001524323   FALSE
MSTRG.26676.9 ENSG00000250682 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00491 lncRNA   1.534453 0.9654337 1.883461 0.02397794 0.09513213 0.9569097 0.08787282 0.13718186 0.06894136 0.05264624 0.06894136 -0.8987467 0.07315000 0.14043333 0.03490000 -0.10553333 0.268580184 0.001524323   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000250682 E001 4.0620335 0.041182641 0.5160536722 0.6506520706 5 102604220 102604745 526 - 0.646 0.738 0.381
ENSG00000250682 E002 1.4938222 0.285491389 0.0247323941 0.0613266388 5 102608479 102608496 18 - 0.562 0.000 -11.422
ENSG00000250682 E003 7.7529262 0.004677569 0.5532689452 0.6824435624 5 102608497 102608670 174 - 0.987 0.914 -0.271
ENSG00000250682 E004 13.7503032 0.001730233 0.2031569670 0.3301718990 5 102608671 102609155 485 - 1.219 1.102 -0.418
ENSG00000250682 E005 6.7728262 0.002914046 0.0183174296 0.0478269941 5 102609156 102609259 104 - 0.998 0.700 -1.158
ENSG00000250682 E006 7.4434069 0.014817461 0.0165157854 0.0438788056 5 102609260 102609390 131 - 1.042 0.732 -1.188
ENSG00000250682 E007 7.4798248 0.002850422 0.0263789840 0.0647082660 5 102609391 102609556 166 - 1.032 0.765 -1.018
ENSG00000250682 E008 10.4528868 0.002995734 0.1265523513 0.2293464768 5 102609557 102609766 210 - 1.118 0.956 -0.593
ENSG00000250682 E009 1.0632359 0.012198908 0.1522359963 0.2647218628 5 102611893 102611955 63 - 0.412 0.147 -1.977
ENSG00000250682 E010 0.4741261 0.022551193 0.8549554815 0.9102896690 5 102617858 102617928 71 - 0.184 0.147 -0.392
ENSG00000250682 E011 1.4832251 0.009047369 0.1949059394 0.3198768593 5 102636143 102636291 149 - 0.493 0.256 -1.394
ENSG00000250682 E012 0.0000000       5 102636292 102636371 80 -      
ENSG00000250682 E013 0.0000000       5 102636372 102636460 89 -      
ENSG00000250682 E014 11.6643657 0.005055749 0.0005109714 0.0022008457 5 102671227 102671342 116 - 0.923 1.243 1.161
ENSG00000250682 E015 11.4438644 0.002023501 0.0001405243 0.0007057771 5 102671343 102671488 146 - 0.909 1.252 1.245
ENSG00000250682 E016 9.0552259 0.002215517 0.0002622439 0.0012257306 5 102671489 102671765 277 - 0.797 1.166 1.373