ENSG00000250337

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000503107 ENSG00000250337 HEK293_OSMI2_2hA HEK293_TMG_2hB PURPL lncRNA lncRNA 3.266876 2.750918 3.115285 0.3133423 0.0820996 0.1788398 0.23838775 0.2418597 0.00000000 0.24185973 0.00000000 -4.6545486 0.06544583 0.08110000 0.000000000 -0.08110000 0.769704652 0.001971378   FALSE
ENST00000653835 ENSG00000250337 HEK293_OSMI2_2hA HEK293_TMG_2hB PURPL lncRNA lncRNA 3.266876 2.750918 3.115285 0.3133423 0.0820996 0.1788398 0.08375602 0.2325085 0.01418248 0.12630240 0.01418248 -3.3260009 0.02859167 0.07776667 0.004766667 -0.07300000 0.092066347 0.001971378   FALSE
ENST00000659860 ENSG00000250337 HEK293_OSMI2_2hA HEK293_TMG_2hB PURPL lncRNA lncRNA 3.266876 2.750918 3.115285 0.3133423 0.0820996 0.1788398 0.66578886 0.5100353 1.25029422 0.08081024 0.13171411 1.2770790 0.21176250 0.18340000 0.400166667 0.21676667 0.001971378 0.001971378 FALSE FALSE
ENST00000671061 ENSG00000250337 HEK293_OSMI2_2hA HEK293_TMG_2hB PURPL lncRNA lncRNA 3.266876 2.750918 3.115285 0.3133423 0.0820996 0.1788398 0.40447972 0.2971682 0.14278164 0.08153461 0.07608381 -1.0075578 0.11570833 0.10366667 0.045166667 -0.05850000 0.426552674 0.001971378   FALSE
ENST00000688783 ENSG00000250337 HEK293_OSMI2_2hA HEK293_TMG_2hB PURPL lncRNA lncRNA 3.266876 2.750918 3.115285 0.3133423 0.0820996 0.1788398 0.42441805 0.1651315 0.38780680 0.05787700 0.08708937 1.1836297 0.12491250 0.05913333 0.124300000 0.06516667 0.276764632 0.001971378   FALSE
MSTRG.26002.34 ENSG00000250337 HEK293_OSMI2_2hA HEK293_TMG_2hB PURPL lncRNA   3.266876 2.750918 3.115285 0.3133423 0.0820996 0.1788398 0.39073497 0.2208969 0.36556670 0.12706039 0.18283163 0.7018203 0.11832083 0.07283333 0.117266667 0.04443333 0.915095754 0.001971378   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000250337 E001 0.1482932 0.041268343 5.350122e-01   5 27217714 27218048 335 + 0.000 0.115 8.756
ENSG00000250337 E002 0.0000000       5 27218049 27218333 285 +      
ENSG00000250337 E003 0.0000000       5 27281013 27281091 79 +      
ENSG00000250337 E004 0.0000000       5 27407043 27407118 76 +      
ENSG00000250337 E005 0.0000000       5 27438377 27438530 154 +      
ENSG00000250337 E006 0.0000000       5 27472223 27472234 12 +      
ENSG00000250337 E007 0.0000000       5 27472235 27472269 35 +      
ENSG00000250337 E008 0.0000000       5 27472270 27472270 1 +      
ENSG00000250337 E009 0.0000000       5 27472271 27472275 5 +      
ENSG00000250337 E010 0.0000000       5 27472276 27472279 4 +      
ENSG00000250337 E011 0.0000000       5 27472280 27472280 1 +      
ENSG00000250337 E012 0.0000000       5 27472281 27472282 2 +      
ENSG00000250337 E013 0.0000000       5 27472283 27472283 1 +      
ENSG00000250337 E014 0.2214452 0.039723217 5.313102e-01   5 27472284 27472291 8 + 0.000 0.115 10.744
ENSG00000250337 E015 1.6136465 0.010584864 8.698931e-01 9.203094e-01 5 27472292 27472293 2 + 0.439 0.400 -0.206
ENSG00000250337 E016 1.9866072 0.012020890 8.605716e-01 9.140705e-01 5 27472294 27472294 1 + 0.491 0.450 -0.205
ENSG00000250337 E017 2.7207879 0.013268673 6.567557e-01 7.662479e-01 5 27472295 27472300 6 + 0.618 0.534 -0.377
ENSG00000250337 E018 2.7207879 0.013268673 6.567557e-01 7.662479e-01 5 27472301 27472303 3 + 0.618 0.534 -0.377
ENSG00000250337 E019 3.8246184 0.007330970 5.906605e-01 7.134950e-01 5 27472304 27472306 3 + 0.653 0.719 0.277
ENSG00000250337 E020 5.3681317 0.100648490 3.743623e-01 5.187794e-01 5 27472307 27472322 16 + 0.715 0.871 0.621
ENSG00000250337 E021 8.9162110 0.024068423 4.805418e-01 6.188131e-01 5 27472323 27472351 29 + 0.956 1.036 0.296
ENSG00000250337 E022 11.7133587 0.002330285 4.730993e-01 6.121076e-01 5 27472352 27472382 31 + 1.073 1.127 0.196
ENSG00000250337 E023 9.6474588 0.001776400 8.111226e-01 8.801765e-01 5 27472383 27472388 6 + 1.019 1.029 0.039
ENSG00000250337 E024 16.0342384 0.001174460 3.729246e-01 5.173480e-01 5 27472389 27472452 64 + 1.195 1.254 0.208
ENSG00000250337 E025 16.9156919 0.001159238 1.787352e-01 2.995661e-01 5 27472453 27472519 67 + 1.195 1.289 0.332
ENSG00000250337 E026 0.1482932 0.041268343 5.350122e-01   5 27473471 27473500 30 + 0.000 0.115 10.737
ENSG00000250337 E027 18.3587592 0.001325620 7.809387e-01 8.592398e-01 5 27475535 27475598 64 + 1.283 1.289 0.024
ENSG00000250337 E028 12.1703290 0.003656257 1.683017e-01 2.859934e-01 5 27475599 27475601 3 + 1.047 1.165 0.427
ENSG00000250337 E029 19.1596696 0.001282373 1.361238e-01 2.426490e-01 5 27475602 27475664 63 + 1.241 1.340 0.348
ENSG00000250337 E030 12.7294534 0.001516763 8.050421e-01 8.759517e-01 5 27475665 27475695 31 + 1.155 1.118 -0.132
ENSG00000250337 E031 1.3412746 0.020531734 9.793277e-03 2.825444e-02 5 27475696 27475781 86 + 0.579 0.115 -3.208
ENSG00000250337 E032 2.0829295 0.080556277 6.036649e-02 1.272349e-01 5 27475782 27476068 287 + 0.653 0.282 -1.936
ENSG00000250337 E033 0.7717446 0.267781564 7.088886e-01 8.064325e-01 5 27476069 27476086 18 + 0.311 0.204 -0.805
ENSG00000250337 E034 5.7014267 0.003016257 6.000789e-01 7.213763e-01 5 27476087 27476158 72 + 0.795 0.849 0.208
ENSG00000250337 E035 13.6358239 0.082467679 2.516050e-02 6.220985e-02 5 27476159 27477638 1480 + 1.329 0.960 -1.325
ENSG00000250337 E036 10.3203298 0.001668367 7.643981e-01 8.474787e-01 5 27477639 27477679 41 + 1.073 1.029 -0.160
ENSG00000250337 E037 15.2573933 0.001231718 7.614016e-02 1.533317e-01 5 27477680 27477801 122 + 1.298 1.137 -0.569
ENSG00000250337 E038 0.8942170 0.014396704 5.525983e-03 1.735459e-02 5 27477802 27478027 226 + 0.491 0.000 -14.053
ENSG00000250337 E039 1.5532672 0.047271656 6.544075e-01 7.645826e-01 5 27482412 27482554 143 + 0.439 0.347 -0.518
ENSG00000250337 E040 2.1380975 0.011340958 1.197206e-01 2.195756e-01 5 27484571 27484925 355 + 0.618 0.345 -1.373
ENSG00000250337 E041 10.8988331 0.001616639 9.691225e-02 1.857728e-01 5 27484926 27485029 104 + 1.165 0.991 -0.634
ENSG00000250337 E042 26.4634197 0.006289019 3.963978e-07 3.575976e-06 5 27485030 27486146 1117 + 1.611 1.225 -1.334
ENSG00000250337 E043 5.1951476 0.003220097 3.372798e-01 4.811530e-01 5 27489282 27489386 105 + 0.716 0.830 0.457
ENSG00000250337 E044 1.2995567 0.143089787 1.939250e-01 3.187198e-01 5 27489387 27489427 41 + 0.492 0.208 -1.778
ENSG00000250337 E045 2.3314406 0.153102464 9.602530e-01 9.789823e-01 5 27493359 27493569 211 + 0.491 0.505 0.067
ENSG00000250337 E046 1.7079031 0.140773199 9.459959e-01 9.700938e-01 5 27493570 27493687 118 + 0.440 0.404 -0.193
ENSG00000250337 E047 5.3716406 0.005960568 1.876313e-01 3.107568e-01 5 27493688 27494118 431 + 0.685 0.849 0.659
ENSG00000250337 E048 3.8373765 0.011812615 3.109390e-01 4.533813e-01 5 27494119 27494234 116 + 0.579 0.720 0.605
ENSG00000250337 E049 9.8731664 0.001917619 8.699948e-02 1.705927e-01 5 27494235 27494335 101 + 0.921 1.087 0.612
ENSG00000250337 E050 21.2714136 0.001016625 1.591135e-10 2.712461e-09 5 27495949 27496994 1046 + 0.988 1.491 1.779